Patents Assigned to Synthorx, Inc.
  • IMMUNO ONCOLOGY COMBINATION THERAPY WITH IL-2 CONJUGATES AND ANTI-EGFR ANTIBODIES
    Publication number: 20260115295
    Abstract: Disclosed herein are methods for treating a cancer in a subject in need thereof, comprising administering IL-2 conjugates in combination with an anti-EGFR antibody.
    Type: Application
    Filed: August 20, 2025
    Publication date: April 30, 2026
    Applicant: Synthorx, Inc.
    Inventors: Giovanni ABBADESSA, Carolina E. CAFFARO, Joseph LEVEQUE, Marcos MILLA, Jerod PTACIN, Timothy R. WAGENAAR
  • IL-2 conjugates and methods of use thereof
    Patent number: 12521437
    Abstract: Disclosed herein are compositions, kits, and methods comprising interleukin (IL) conjugates (e.g., IL-2 conjugates) useful for the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the interleukin conjugates (e.g., IL-2 conjugates).
    Type: Grant
    Filed: June 17, 2021
    Date of Patent: January 13, 2026
    Assignee: SYNTHORX, INC.
    Inventors: Jerod Ptacin, Carolina E. Caffaro, Marcos Milla
  • Interleukin 10 conjugates and uses thereof
    Patent number: 12491254
    Abstract: Disclosed herein are interleukin 10 conjugates and uses in the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the IL-10 conjugates.
    Type: Grant
    Filed: May 6, 2021
    Date of Patent: December 9, 2025
    Assignee: SYNTHORX, INC.
    Inventors: Carolina E. Caffaro, Jerod Ptacin, Marcos Milla
  • CYTOKINE CONJUGATES FOR THE TREATMENT OF PROLIFERATIVE AND INFECTIOUS DISEASES
    Publication number: 20250325632
    Abstract: Disclosed herein are interleukin (IL) conjugates (e.g., IL-2 conjugates) and use in the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the interleukin conjugates (e.g., IL-2 conjugates).
    Type: Application
    Filed: January 16, 2025
    Publication date: October 23, 2025
    Applicant: Synthorx, Inc.
    Inventors: Jerod PTACIN, Carolina E. CAFFARO, Marcos MILLA
  • CYTOKINE CONJUGATES FOR THE TREATMENT OF AUTOIMMUNE DISEASES
    Publication number: 20250325633
    Abstract: Disclosed herein are interleukin (IL) conjugates (e.g., IL-2 conjugates) and use in the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the interleukin conjugates (e.g., IL-2 conjugates).
    Type: Application
    Filed: July 2, 2025
    Publication date: October 23, 2025
    Applicant: Synthorx, Inc.
    Inventors: Carolina E. CAFFARO, Marcos MILLA, Jerod PTACIN
  • INCORPORATION OF UNNATURAL NUCLEOTIDES AND METHODS THEREOF
    Publication number: 20250270535
    Abstract: Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.
    Type: Application
    Filed: May 2, 2025
    Publication date: August 28, 2025
    Applicants: Synthorx, Inc., The Scripps Research Institute
    Inventors: Jerod PTACIN, Carolina CAFFARO, Hans AERNI, Yorke ZHANG, Emil C. FISCHER, Aaron W. FELDMAN, Vivian T. DIEN, Floyd E. ROMESBERG
  • Cytokine conjugates for the treatment of autoimmune diseases
    Patent number: 12377131
    Abstract: Disclosed herein are interleukin (IL) conjugates (e.g., IL-2 conjugates) and use in the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the interleukin conjugates (e.g., IL-2 conjugates).
    Type: Grant
    Filed: March 6, 2023
    Date of Patent: August 5, 2025
    Assignee: SYNTHORX, INC.
    Inventors: Carolina E. Caffaro, Marcos Milla, Jerod Ptacin
  • Incorporation of unnatural nucleotides and methods thereof
    Patent number: 12319944
    Abstract: Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.
    Type: Grant
    Filed: October 4, 2023
    Date of Patent: June 3, 2025
    Assignees: THE SCRIPPS RESEARCH INSTITUTE, SYNTHORX, INC.
    Inventors: Jerod Ptacin, Carolina Caffaro, Hans Aerni, Yorke Zhang, Emil C. Fischer, Aaron W. Feldman, Vivian T. Dien, Floyd E. Romesberg
  • Cytokine conjugates for the treatment of proliferative and infectious diseases
    Patent number: 12318431
    Abstract: Disclosed herein are interleukin (IL) conjugates (e.g., IL-2 conjugates) and use in the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the interleukin conjugates (e.g., IL-2 conjugates).
    Type: Grant
    Filed: June 1, 2023
    Date of Patent: June 3, 2025
    Assignee: SYNTHORX, INC.
    Inventors: Jerod Ptacin, Carolina E. Caffaro, Marcos Milla
  • IL-2 Conjugates and Methods of Use to Treat Autoimmune Diseases
    Publication number: 20250154218
    Abstract: Disclosed herein are compositions, kits, and methods comprising interleukin (IL) conjugates (e.g., IL-2 conjugates) useful for the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the interleukin conjugates (e.g., IL-2 conjugates).
    Type: Application
    Filed: September 16, 2024
    Publication date: May 15, 2025
    Applicant: Synthorx, Inc.
    Inventors: Jerod PTACIN, Carolina E. CAFFARO, Marcos MILLA
  • INCORPORATION OF UNNATURAL NUCLEOTIDES AND METHODS THEREOF
    Publication number: 20250084410
    Abstract: Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.
    Type: Application
    Filed: November 21, 2024
    Publication date: March 13, 2025
    Applicant: Synthorx, Inc.
    Inventors: Jerod PTACIN, Denis A. MALYSHEV, Carolina E. CAFFARO
  • METHODS FOR SELECTING SUBJECTS AND TREATING CANCER WITH IL-2 THERAPY
    Publication number: 20250075276
    Abstract: Described herein are methods for treating a cancer in a subject, the method comprising administering an IL-2 therapy to the subject, wherein in a sample from the subject, a set of markers has elevated expression or decreased expression.
    Type: Application
    Filed: January 12, 2023
    Publication date: March 6, 2025
    Applicant: Synthorx, Inc.
    Inventors: Kirk BEEBE, Joel EISNER, Gregory MAYHEW, Marcos MILLA, Jill MOONEY
  • Il-2 conjugates and methods of use to treat autoimmune diseases
    Patent number: 12234271
    Abstract: Disclosed herein are compositions, kits, and methods comprising interleukin (IL) conjugates (e.g., IL-2 conjugates) useful for the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the interleukin conjugates (e.g., IL-2 conjugates).
    Type: Grant
    Filed: September 9, 2020
    Date of Patent: February 25, 2025
    Assignee: Synthorx, Inc.
    Inventors: Jerod Ptacin, Carolina E. Caffaro, Marcos Milla
  • IL-15 Conjugates and Uses Thereof
    Publication number: 20240383957
    Abstract: Disclosed herein are interleukin (IL)-15 conjugates and use in the treatment of one or more indications. Also described herein include pharmaceutical compositions and kits comprising one or more of IL-15 conjugates. In some embodiments, at least one amino acid residue in the IL-15 conjugate is replaced by the structure of Formula (I) described herein.
    Type: Application
    Filed: January 26, 2024
    Publication date: November 21, 2024
    Applicant: Synthorx, Inc.
    Inventors: Carolina E. CAFFARO, Jerod PTACIN, Marcos MILLA
  • IL-15 Conjugates and Uses Thereof
    Publication number: 20240287151
    Abstract: Disclosed herein are interleukin (IL) 15 conjugates and use in the treatment of one or more indications. Also described herein include pharmaceutical compositions and kits comprising one or more of IL-15 conjugates.
    Type: Application
    Filed: January 17, 2024
    Publication date: August 29, 2024
    Applicant: Synthorx, Inc.
    Inventors: Carolina E. CAFFARO, Jerod PTACIN, Marcos MILLA
  • HEAD AND NECK CANCER COMBINATION THERAPY COMPRISING AN IL-2 CONJUGATE AND CETUXIMAB
    Publication number: 20240226309
    Abstract: Disclosed herein are methods for treating head and neck squamous cell carcinoma (HNSCC) in a subject in need thereof, comprising administering IL-2 conjugates in combination with cetuximab.
    Type: Application
    Filed: November 30, 2023
    Publication date: July 11, 2024
    Applicant: Synthorx, Inc.
    Inventors: Giovanni ABBADESSA, Carolina E. CAFFARO, Brigitte DEMERS, Joseph LEVEQUE, Wan-Ju MENG, Marcos MILLA, Jerod PTACIN
  • CYTOKINE CONJUGATES FOR THE TREATMENT OF PROLIFERATIVE AND INFECTIOUS DISEASES
    Publication number: 20240082359
    Abstract: Disclosed herein are interleukin (IL) conjugates (e.g., IL-2 conjugates) and use in the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the interleukin conjugates (e.g., IL-2 conjugates).
    Type: Application
    Filed: June 1, 2023
    Publication date: March 14, 2024
    Applicant: Synthorx, Inc.
    Inventors: Jerod PTACIN, Carolina E. CAFFARO, Marcos MILLA
  • IL-15 conjugates and uses thereof
    Patent number: 11919934
    Abstract: Disclosed herein are interleukin (IL) 15 conjugates and use in the treatment of one or more indications. Also described herein include pharmaceutical compositions and kits comprising one or more of IL-15 conjugates.
    Type: Grant
    Filed: August 25, 2020
    Date of Patent: March 5, 2024
    Assignee: SYNTHORX, INC.
    Inventors: Carolina E. Caffaro, Jerod Ptacin, Marcos Milla
  • INCORPORATION OF UNNATURAL NUCLEOTIDES AND METHODS THEREOF
    Publication number: 20240043823
    Abstract: Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.
    Type: Application
    Filed: October 4, 2023
    Publication date: February 8, 2024
    Applicants: Synthorx, Inc., The Scripps Research Institute
    Inventors: Jerod PTACIN, Carolina CAFFARO, Hans AERNI, Yorke ZHANG, Emil C. FISCHER, Aaron W. FELDMAN, Vivian T. DIEN, Floyd E. ROMESBERG
  • IMMUNO ONCOLOGY THERAPIES WITH IL-2 CONJUGATES
    Publication number: 20230416327
    Abstract: Disclosed herein are methods and uses relating to administering IL-2 conjugates or methods useful for the treatment of one or more indications, such as the treatment of proliferative diseases. Also described herein are pharmaceutical compositions and kits comprising one or more of the IL-2 conjugates.
    Type: Application
    Filed: April 6, 2023
    Publication date: December 28, 2023
    Applicant: Synthorx, Inc.
    Inventors: Carolina E. CAFFARO, Joseph LEVEQUE, Marcos MILLA, Jerod PTACIN, Laura SHAWVER