Abstract: A method is provided for biosynthetic production of cannabinoids in microorganisms from a carbon source precursor. This method describes the genetic modifications needed to engineer microorganisms to produce cannabinoids as well as a method for identifying and quantifying cannabinoids from fermentation broth. A system is also provided for tuning the method to produce different cannabinoids of interest by systematically modulating the enzymes encoded by the genetic modifications introduced in the microorganism.
Type:
Grant
Filed:
October 12, 2020
Date of Patent:
October 4, 2022
Assignee:
SYNTIVA THERAPEUTICS, INC.
Inventors:
Adam Davidovich, Brian Chan, Neil Gupta, Alim Ladha
Abstract: A method is provided for biosynthetic production of cannabinoids in microorganisms from a carbon source precursor. This method describes the genetic modifications needed to engineer microorganisms to produce cannabinoids as well as a method for identifying and quantifying cannabinoids from fermentation broth. A system is also provided for tuning the method to produce different cannabinoids of interest by systematically modulating the enzymes encoded by the genetic modifications introduced in the microorganism.
Type:
Grant
Filed:
June 14, 2019
Date of Patent:
October 13, 2020
Assignee:
SYNTIVA THERAPEUTICS, INC.
Inventors:
Adam Davidovich, Brian Chan, Neil Gupta, Alim Ladha