Abstract: Disclosed is a cosmetic treatment method for the skin, in particular for preventing and/or repairing the signs of skin ageing, that includes administering, and in particular applying topically to the skin, a composition containing, in a cosmetically acceptable vehicle, a compound of general formula (I): (formula I) in which R1, R2, R3, R4, R5, R6, R7 and R8, which may be identical or different, each represent a hydrogen atom, a halogen atom, a hydroxyl group, a linear or branched, saturated or unsaturated, C1-C16 hydrocarbon radical, or an —OR? radical in which R? represents a linear or branched, saturated or unsaturated, C1-C16 hydrocarbon radical, at least one group from R1, R2, R3, R4, R5, R6, R7 and R8 not representing a hydrogen atom or a halogen atom, Z represents a covalent bond or a spacer arm, or one of the salts of same.

Abstract: The present invention concerns the development of a model to evaluate active substances targeting the epidermis. It more particularly relates to the preparation of mixed spheroids of melanocytes and keratinocytes reproducing cell interactions occurring in the epidermis, to the spheroids as such and to the uses thereof.