Abstract: Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.
Type:
Grant
Filed:
September 5, 2021
Date of Patent:
October 24, 2023
Assignees:
RAMOT AT TEL-AVIV UNIVERSITY LTD., YEDA RESEARCH AND DEVELOPMENT CO. LTD., SYNVACCINE LTD.
Inventors:
Tamir Tuller, Eli Goz, Shimshi Atar, Hadas Zur
Abstract: Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.
Type:
Application
Filed:
September 5, 2021
Publication date:
January 13, 2022
Applicants:
RAMOT AT TEL-AVIV UNIVERSITY LTD., YEDA RESEARCH AND DEVELOPMENT CO. LTD., SYNVACCINE LTD.
Inventors:
Tamir TULLER, Eli GOZ, Shimshi ATAR, Hadas ZUR
Abstract: Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.
Type:
Grant
Filed:
September 29, 2016
Date of Patent:
September 7, 2021
Assignees:
RAMOT AT TEL-AVIV UNIVERSITY LTD., YEDA RESEARCH AND DEVELOPMENT CO. LTD., SYNVACCINE LTD.
Inventors:
Tamir Tuller, Eli Goz, Shimshi Atar, Hadas Zur