Patents Assigned to Syrrx, Inc.
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Patent number: 6994749Abstract: A microfluidic device is provided that comprises: a substrate; and a plurality of microvolumes at least partially defined by the substrate, each microvolume comprising a first submicrovolume and a second submicrovolume in fluid communication with the first submicrovolume when the device is rotated about a first rotational axis; wherein rotation of the device about the first rotational axis causes a fixed volume to be transported to each of the second submicrovolumes.Type: GrantFiled: January 29, 2002Date of Patent: February 7, 2006Assignee: SYRRX, Inc.Inventor: Peter R. David
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Patent number: 6916372Abstract: A microfluidic device comprising: a substrate shaped so as to provide the device with an axis of rotation about which the device may be rotated; and a plurality of microvolumes at least partially defined by the substrate, each microvolume comprising a first submicrovolume and a second submicrovolume that is in fluid communication with the first submicrovolume when the device is rotated, the plurality of microvolumes being arranged in the device such that fluid in the first submicrovolumes of multiple of the microvolumes is transported to the second submicrovolumes of the associated microvolumes when the device is rotated about the rotational axis.Type: GrantFiled: January 29, 2002Date of Patent: July 12, 2005Assignee: Syrrx, Inc.Inventor: Peter R. David
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Patent number: 6872250Abstract: A method for determining crystallization conditions for a material, the method comprising: taking a microfluidic device comprising one or more lumens having microvolume dimensions and a plurality of different crystallization samples within the one or more lumens, the plurality of crystallization samples comprising a material to be crystallized and crystallization conditions that vary among the plurality of crystallization samples; transporting the plurality of different crystallization samples within the lumens; and identifying a precipitate or crystal formed in the one or more lumens.Type: GrantFiled: January 29, 2002Date of Patent: March 29, 2005Assignee: Syrrx, Inc.Inventors: Peter R. David, Nathaniel E. David
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Patent number: 6837926Abstract: A microfluidic device is provided that comprises: a card shaped substrate having first and second opposing faces; one or more microvolumes at least partially defined by a first face of the card shaped substrate; and one or more grooves at least partially defined by a second face of the card shaped substrate; wherein a lateral footprint of at least a portion of the one or more grooves overlaps with a lateral footprint of at least one of the one or more microvolumes.Type: GrantFiled: January 29, 2002Date of Patent: January 4, 2005Assignee: Syrrx, Inc.Inventor: Peter R. David
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Patent number: 6837927Abstract: A microfluidic device is provided that comprises: a substrate; and a plurality of microvolumes at least partially defined by the substrate, each microvolume comprising a first submicrovolume and a second submicrovolume that is in fluid communication with the first submicrovolume when the device is rotated, the plurality of microvolumes being arranged in the device such that fluid in the first submicrovolumes of multiple of the microvolumes are transported to second submicrovolumes of the associated microvolumes when the device is rotated.Type: GrantFiled: January 29, 2002Date of Patent: January 4, 2005Assignee: Syrrx, Inc.Inventor: Peter R. David
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Publication number: 20040266769Abstract: Compounds that may be used to inhibit histone deacetylase having the formulaType: ApplicationFiled: March 17, 2004Publication date: December 30, 2004Applicant: Syrrx, Inc.Inventors: Jerome C. Bressi, Jason W. Brown, Sheldon X. Cao, Anthony R. Gangloff, Andrew J. Jennings, Jeffrey A. Stafford, Phong H. Vu, Xiao-Yi Xiao
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Publication number: 20040259870Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 protease that comprise a compound comprising the formula: 1Type: ApplicationFiled: March 24, 2004Publication date: December 23, 2004Applicant: Syrrx, Inc.Inventors: Jun Feng, Stephen L. Gwaltney, Stephen W. Kaldor, Jeffrey A. Stafford, Michael B. Wallace, Zhiyuan Zhang
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Publication number: 20040254220Abstract: Compounds that may be used to inhibit histone deacetylase having the formulaType: ApplicationFiled: March 17, 2004Publication date: December 16, 2004Applicant: Syrrx, Inc.Inventors: Jerome C. Bressi, Jason W. Brown, Sheldon X. Cao, Anthony R. Gangloff, Andrew J. Jennings, Jeffrey A. Stafford, Phong H. Vu, Xiao-Yi Xiao
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Publication number: 20040254226Abstract: Pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound with the formula: 1Type: ApplicationFiled: May 13, 2004Publication date: December 16, 2004Applicant: Syrrx, Inc.Inventors: Jun Feng, Stephen L. Gwaltney, Jeffrey A. Stafford, Michael B. Wallace, Xiao-Yi Xiao, Zhiyuan Zhang
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Publication number: 20040242566Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and othe S9 proteases that comprise a compound comprising the formula: 1Type: ApplicationFiled: March 24, 2004Publication date: December 2, 2004Applicant: Syrrx, Inc.Inventors: Jun Feng, Stephen L. Gwaltney, Stephen W. Kaldor, Jeffrey A. Stafford, Michael B. Wallace, Zhiyuan Zhang
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Publication number: 20040242568Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising the formula: 1Type: ApplicationFiled: March 24, 2004Publication date: December 2, 2004Applicant: Syrrx, Inc.Inventors: Jun Feng, Stephen L. Gwaltney, Stephen W. Kaldor, Jeffrey A. Stafford, Michael B. Wallace, Zhiyuan Zhang
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Patent number: 6811609Abstract: A microfluidic device is provided that comprises: a substrate; one or more microvolumes at least partially defined by the substrate, each microvolume comprising a first submicrovolume, a second submicrovolume where fluid in the first submicrovolume is transported to the second submicrovolume when the device is rotated about a first rotational axis, and a third submicrovolume where fluid in the first submicrovolume is transported to the third submicrovolume when the device is rotated about a second, different rotational axis.Type: GrantFiled: January 29, 2002Date of Patent: November 2, 2004Assignee: Syrrx, Inc.Inventor: Peter R. David
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Patent number: 6797056Abstract: A microfluidic method is provided that comprises: delivering first and second fluids to a lumen of a microfluidic device such that the first and second fluids flow adjacent to each other within the lumen without mixing except for diffusion at an interface between the first and second fluids, wherein the first fluid is different than the second fluid.Type: GrantFiled: January 29, 2002Date of Patent: September 28, 2004Assignee: Syrrx, Inc.Inventor: Peter R. David
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Patent number: 6780240Abstract: A microfluidic method is provided that comprises: taking a microfluidic device comprising a plurality of microvolumes; and causing movement of material in a same manner within the plurality of microvolumes by applying centrifugal forces to the material.Type: GrantFiled: January 29, 2002Date of Patent: August 24, 2004Assignee: Syrrx, Inc.Inventor: Peter R. David
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Patent number: 6761766Abstract: A microfluidic method comprising: taking a microfluidic device comprising a substrate, and a plurality of microvolumes at least partially defined by the substrate, each microvolume comprising a first submicrovolume and a second submicrovolume in fluid communication with the first submicrovolume; adding fluids to the first submicrovolumes; and applying a centrifugal force to the device to cause a same volume of fluid to be transported to the second microvolumes from the first submicrovolumes.Type: GrantFiled: January 29, 2002Date of Patent: July 13, 2004Assignee: Syrrx, Inc.Inventor: Peter R. David
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Patent number: 6719840Abstract: A method is provided for determining crystallization conditions for a material, the method comprising: taking a plurality of different crystallization samples in an enclosed microvolume, the plurality of crystallization samples comprising a material to be crystallized and crystallization conditions which vary among the plurality of crystallization samples; allowing crystals of the material to form in plurality of crystallization samples; and identifying which of the plurality of crystallization samples form crystals.Type: GrantFiled: June 8, 2001Date of Patent: April 13, 2004Assignee: Syrrx, Inc.Inventors: Peter R. David, Nathaniel E. David