Patents Assigned to Systagenix Wound Management (US), Inc.
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Publication number: 20120078154Abstract: A wound dressing material comprising a solid substrate having interstitial spaces therein, wherein said substrate is a hydrophilic open-cell foam material, and wherein said interstitial spaces are at least partially filled by a hydrophilic polyurethane foam different from said substrate foam material. Also provided is a method of making a porous wound dressing material comprising the steps of: providing a substrate of a solid hydrophilic first foam material; applying a fluid or gel polyurethane foam prepolymer mixture to at least one surface of said solid substrate; and curing said prepolymer in contact with said solid substrate.Type: ApplicationFiled: February 3, 2010Publication date: March 29, 2012Applicant: SYSTAGENIX WOUND MANAGEMENT(US), INC.Inventors: William Pigg, Michelle Del Bono, Paul Howard lowing
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Patent number: 8124826Abstract: A wound dressing material comprising a polymeric substrate, a silver salt, and a dyestuff to photostabilize the silver salt. The substrate may comprise collagen and/or oxidized regenerated cellulose complexed to Ag+, and the dyestuff may for example be an aniline or acridine dye. Also provided are methods of making such materials, and wound dressings comprising such materials.Type: GrantFiled: November 17, 2004Date of Patent: February 28, 2012Assignee: Systagenix Wound Management (US), Inc.Inventors: Deborah Addison, David Greenhalgh, Breda Mary Cullen
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Patent number: 8124370Abstract: Described herein are methods of detecting a wound infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with a cationic anti-microbial peptide that is degradable by an enzyme produced and/or secreted by a microorganism, and detecting degradation or the absence of degradation of the peptide, as an indicator of the presence or absence of the enzyme in the sample, and thus indicative of the presence or absence of a microorganism in the sample. The present invention also features a biosensor for detecting the presence or absence of a microorganism in a sample.Type: GrantFiled: January 30, 2004Date of Patent: February 28, 2012Assignee: Systagenix Wound Management (US), Inc.Inventors: Mitchell C. Sanders, Gerard J. Colpas, Shite Sebastian, Diane Ellis-Busby
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Patent number: 8097272Abstract: The invention provides a wound dressing comprising a layered material comprising a hydrophilic foam layer formed from a first polyurethane and a hydrogel layer formed from a second polyurethane, wherein the hydrogel layer is laminated to the hydrophilic foam layer. The invention also provides methods for preparing the same.Type: GrantFiled: May 27, 2003Date of Patent: January 17, 2012Assignee: Systagenix Wound Management (US), Inc.Inventor: Deborah Addison
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Publication number: 20120010099Abstract: The present invention relates to a method of determining the microbial bioburden in a wound (in particular a diabetic ulcer) in a test subject, the method comprising the step of measuring the level of a cytokine in a wound sample, wherein a cytokine level lower than a reference level indicates a significant microbial bioburden in the wound (or a cytokine level higher than a reference level indicates an insignificant microbial bioburden in the wound). The invention provides methods of diagnosis, prognosis and treatment of wound infection, and devices and kits for use in such methods.Type: ApplicationFiled: September 2, 2011Publication date: January 12, 2012Applicant: Systagenix Wound Management (US), INC.Inventors: Philip Stephens, Ryan Moseley, Rachael Clark, Breda Mary Cullen
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Patent number: 8067370Abstract: Disclosed is a wound dressing comprising a therapeutic agent and a matrix comprising polymers joined by cross-linkages, wherein the cross-linkages comprise oligopeptidic sequences which are cleavable by a kallikrein associated with wound fluid such that the rate of release of the therapeutic agent increases in the presence of elevated kallikrein levels.Type: GrantFiled: March 4, 2008Date of Patent: November 29, 2011Assignee: Systagenix Wound Management (US), Inc.Inventors: Patrick J. Trotter, Breda M. Cullen
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Patent number: 8063052Abstract: The present invention relates to the use of p38 MAP kinase inhibitors and p38 MAP kinase inhibition to promote wound healing.Type: GrantFiled: August 31, 2005Date of Patent: November 22, 2011Assignee: Systagenix Wound Management (US), Inc.Inventor: Stephen M. Gunnigle
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Patent number: 8058499Abstract: A wound dressing comprising: a liquid-permeable top sheet having a wound facing surface and a back surface, said top sheet being adapted to block or restrict passage of liquid from the back surface to the wound facing surface; and an insoluble hydrogel layer adjacent to the back surface of the top sheet.Type: GrantFiled: November 22, 2002Date of Patent: November 15, 2011Assignee: Systagenix Wound Management (US), Inc.Inventors: Derek Silcock, Andrew James Kirkwood
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Patent number: 8012698Abstract: The present invention relates to a method of determining the microbial bioburden in a wound (in particular a diabetic ulcer) in a test subject, the method comprising the step of measuring the level of a cytokine in a wound sample, wherein a cytokine level lower than a reference level indicates a significant microbial bioburden in the wound (or a cytokine level higher than a reference level indicates an insignificant microbial bioburden in the wound). The invention provides methods of diagnosis, prognosis and treatment of wound infection, and devices and kits for use in such methods.Type: GrantFiled: March 31, 2008Date of Patent: September 6, 2011Assignee: Systagenix Wound Management (US), Inc.Inventors: Philip Stephens, Ryan Moseley, Rachael Clark, Breda Mary Cullen
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Patent number: 7955572Abstract: A sample collection and testing device comprising: An elongate housing (1) having a first end and a second end and a longitudinal axis; an analytical element (4) retained in the housing; a sample collector assembly extending from the first end of the housing and comprising a sample collector (24) in fluid communication with the analytical element (4); a swing arm (2) attached to the housing by a pivot fitting (44), said swing arm having proximal and distal ends; and a cap (40) at the distal end of the swing arm (2); wherein the device comprises a slide to allow limited linear movement of the cap (40) substantially along the longitudinal axis of the housing (1), and wherein the pivot fitting (44) allows the swing arm to rotate about a pivot axis substantially perpendicular to the said longitudinal axis, whereby the swing arm (2) is movable between a sample collection configuration in which the cap (40) is remote from the sample collector (24) and a sample analysis configuration in which the cap (40) encloses tType: GrantFiled: March 2, 2007Date of Patent: June 7, 2011Assignee: Systagenix Wound Management (US), Inc.Inventors: Matthew Hannant, Stephen J. Irwin, Simon William Bayliff
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Patent number: 7794925Abstract: A method of predicting or diagnosing clinical infection of a wound comprising measuring the concentration of a marker associated with an inflammatory response in wound fluid, wherein the marker is a fibronectin fragment, a neutrophil protease or a macrophage protease. Also provided is a use of a wound dressing or biosensor comprising components of an assay system for measuring the concentration of a marker associated with an inflammatory response, wherein the marker is a fibronectin fragment, a neutrophil protease or a macrophage protease, for use in the manufacture of a medicament for predicting the likelihood of clinical infection of the wound or for diagnosing clinical infection of a wound.Type: GrantFiled: November 5, 2002Date of Patent: September 14, 2010Assignee: Systagenix Wound Management (US), Inc.Inventor: Breda Mary Cullen
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Publication number: 20100209481Abstract: A wound dressing composition comprising a non-viable cell lysate or releasate derived from a hepatocyte cell or an inflammatory cell such as a macrophage. Also provided are wound dressings comprising such compositions, methods of making such compositions, and the use of such compositions for the treatment of wounds.Type: ApplicationFiled: November 2, 2007Publication date: August 19, 2010Applicant: SYSTAGENIX WOUND MANAGEMENT (US) INC.Inventors: Rachael Louise Clark, Breda Mary Cullen, Lindsay Matheson
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Patent number: 7732655Abstract: A wound dressing comprising: a therapeutic agent selected from the group consisting of antimicrobial substances, pain relieving substances, protease inhibitors, and mixtures thereof; and a barrier layer for initially separating the therapeutic agent from a wound fluid in use, wherein the barrier layer comprises a substrate for an enzyme selected from the group consisting of proteases, kallikrein and tissue-plasminogen activator. Preferably the substrate comprises a substrate for elastase or a collagenase. The barrier layer breaks down in infected or chronic wounds, thereby releasing the therapeutic substance selectively into such wounds.Type: GrantFiled: December 6, 2002Date of Patent: June 8, 2010Assignee: Systagenix Wound Management (US), Inc.Inventors: Breda Mary Cullen, Derek Walter Silcock, Jonathan Warrick
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Publication number: 20100099622Abstract: The present invention relates to the use of p38 MAP kinase inhibitors and p38 MAP kinase inhibition to promote wound healing.Type: ApplicationFiled: December 21, 2009Publication date: April 22, 2010Applicant: SYSTAGENIX WOUND MANAGEMENT (US), INC.Inventor: Stephen M. Gunnigle
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Publication number: 20090275872Abstract: A wound dressing composition comprising a partially cured polyurethane fluid. The composition can be injected directly into a wound, where it cures to form a wound filling dressing. Also provided is a wound dressing comprising such a composition. Also provided is a kit for the preparation of such wound dressings, the kit comprising (a) a polyurethane prepolymer; and (b) a curing agent for the polyurethane prepolymer. Preferably, the polyurethane components comprise reaction products of a diisocyanate with castor oil or a related ester of ricinoleic acid or its derivatives.Type: ApplicationFiled: May 22, 2009Publication date: November 5, 2009Applicant: SYSTAGENIX WOUND MANAGEMENT (US), INC.Inventors: Deborah Addison, Edward Schonfeld, Peter Wachtel, Sally-Anne Stephens
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Patent number: 7601546Abstract: A diagnostic test apparatus comprising: a shaft having a first end and a second end; a swab or a biopsy punch mounted on the first end of a shaft; and a cap for fitting over the first end of the shaft, said cap containing at least one diagnostic test reagent; wherein the shaft comprises at least one cap engagement element located proximate to the first end, said element extending radially outwardly of the swab or the biopsy punch for engagement with the cap to retain the cap on the shaft. Also provided are diagnostic caps for use in the test apparatus having a small internal volume and at least one diagnostic test reagent located in or on an absorbent plug inside the cap. Also provided are diagnostic caps for use in the test apparatus having a housing extending from a sample receiving port, said housing defining a lateral flow path for the sample.Type: GrantFiled: February 23, 2005Date of Patent: October 13, 2009Assignee: Systagenix Wound Management (US), Inc.Inventors: Simon W. Bayloff, Michelle Del Bono, Maurice C. Biott, Sylvia Lindsay-Watt
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Publication number: 20090227537Abstract: The invention provides sulfated oxidised regenerated cellulose compounds, sulfated alginates, and the salts and hydrates thereof. The compounds are obtained by sulfation of oxidised regenerated cellulose with sulfur trioxide. The invention also provides pharmaceutical compositions comprising the compounds, in particular compositions for the treatment of medical conditions mediated by a matrix metalloproteinases and anticoagulant pharmaceutical compositions.Type: ApplicationFiled: May 13, 2009Publication date: September 10, 2009Applicant: SYSTAGENIX WOUND MANAGEMENT (US), INC.Inventors: MICHAEL WILLIAM GRADY, Laura Sinclair, Paul Houston, Peter John Doyle
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Patent number: 7538257Abstract: A wound dressing composition comprising a partially cured polyurethane fluid. The composition can be injected directly into a wound, where it cures to form a wound filling dressing. Also provided is a wound dressing comprising such a composition. Also provided is a kit for the preparation of such wound dressings, the kit comprising (a) a polyurethane prepolymer; and (b) a curing agent for the polyurethane prepolymer. Preferably, the polyurethane components comprise reaction products of a diisocyanate with castor oil or a related ester of ricinoleic acid or its derivatives.Type: GrantFiled: October 24, 2003Date of Patent: May 26, 2009Assignee: Systagenix Wound Management (US), Inc.Inventors: Deborah Addison, Edward Schonfeld, Peter Wachtel, Sally-Anne Stephens