Abstract: A microprocessor controlled, general purpose gene synthesizer for programmably synthesizing selected nucleotide sequences. Depending upon a programmed chemistry, metered volumes of selected bases and reagent/solvents are sequentially metered into the bottom of a reaction cell containing solid-supported nucleotides, where desired linkages are achieved in an agitated suspension. Self-refilling syringe metering and electrically initiated, pneumatically operated valving insures economical, non-contaminated synthesis. Preprogrammed, selectable chemistries and operator programmed sequences are operatively coupled under microprocessor control to ensure a general purpose synthesizer.
Type:
Grant
Filed:
August 31, 1983
Date of Patent:
July 1, 1986
Assignee:
Systec Inc.
Inventors:
Richard J. Zelinka, Keiichi Itakura, Carl W. Sims, Bruce E. Kaplan