Patents Assigned to SYSTEM OF SYSTEMS ANALYTICS, INC.
  • Methods for detecting A? oligomers
    Patent number: 10139419
    Abstract: Methods of detecting A? oligomers, such as may be present in a biological sample are described. The methods include detection using flow cytometry, detection using synthetic A? oligomers and/or in vitro methods detecting A? oligomers associated with cells.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: November 27, 2018
    Assignee: SYSTEM OF SYSTEMS ANALYTICS, INC.
    Inventors: Richard O. Cliff, Robert W. Flower, Evgenia G. Matveeva
  • OCULAR DETECTION OF AMYLOID PROTEINS
    Publication number: 20180028691
    Abstract: Described are methods for the detection, in the eye of an individual, of protein aggregates or other misfolded proteins associated with disease using peptide or peptide mimic probes that preferentially associate with the protein aggregates or misfolded proteins, which can be accomplished non-invasively.
    Type: Application
    Filed: October 13, 2017
    Publication date: February 1, 2018
    Applicant: SYSTEM OF SYSTEMS ANALYTICS, INC.
    Inventors: Giora FEUERSTEIN, Richard Cliff
  • Ocular detection of amyloid proteins
    Patent number: 9795692
    Abstract: Described are methods for the detection, in the eye of an individual, of protein aggregates or other misfolded proteins associated with disease using peptide or peptide mimic probes that preferentially associate with the protein aggregates or misfolded proteins, which can be accomplished non-invasively.
    Type: Grant
    Filed: June 5, 2014
    Date of Patent: October 24, 2017
    Assignee: SYSTEM OF SYSTEMS ANALYTICS, INC.
    Inventors: Giora Feuerstein, Richard Cliff
  • Conformationally dynamic peptides
    Patent number: 9696316
    Abstract: Disclosed are novel peptides that are useful, for example, for detecting target proteins having a ?-sheet secondary structure which may be associated with a disease, and for diagnosing and treating such a disease. Related methods and kits also are disclosed.
    Type: Grant
    Filed: June 9, 2014
    Date of Patent: July 4, 2017
    Assignee: SYSTEM OF SYSTEMS ANALYTICS, INC.
    Inventors: D. Roxanne Duan, Jonathan R. Moll, Alan Rudolph, Renee Wegrzyn
  • Detection of conformationally altered proteins
    Patent number: 9638702
    Abstract: The invention provides methods and kits for detecting conformationally altered proteins and prions in a sample. In one embodiment, the conformationally altered proteins and prions are associated with amyloidogenic diseases.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: May 2, 2017
    Assignee: SYSTEM OF SYSTEMS ANALYTICS, INC.
    Inventors: Cindy Orser, Anne Grosset, Eugene A. Davidson
  • Stabilized amyloid-beta oligomers and uses thereof
    Patent number: 9556247
    Abstract: The present invention pertains to stabilized A? oligomer compositions. Methods for generating stabilized A? oligomer compounds are also provided herein. Additionally, screening assays employing the A? oligomer compounds and methods for generating therapeutics with the A? oligomers are also provided. In a particular embodiment, the A? oligomer described herein is comprised of A?42 peptide.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: January 31, 2017
    Assignee: SYSTEM OF SYSTEMS ANALYTICS, INC.
    Inventors: Roxanne Duan, Jonathan Moll, Alan S. Rudolph
  • METHODS FOR DETECTING Aß OLIGOMERS
    Publication number: 20160169913
    Abstract: Methods of detecting A? oligomers, such as may be present in a biological sample are described. The methods include detection using flow cytometry, detection using synthetic A? oligomers and/or in vitro methods detecting A? oligomers associated with cells.
    Type: Application
    Filed: September 4, 2015
    Publication date: June 16, 2016
    Applicant: SYSTEM OF SYSTEMS ANALYTICS, INC.
    Inventors: Richard O. Cliff, Robert W. Flower, Evgenia G. Matveeva