Abstract: The invention relates to an aqueous solution of AuCl3×2H2O or HAuCl4×4H2O, ZnCl2 or ZnSO4, and AgNO3 having an Au3+ concentration of 0.8 mM-1.6 mM, a Zn2+ concentration of 15 ?M-50 ?M, and an Ag+ concentration of 5 ?M-50 ?M. The invention extends to a kit comprising a solution of the invention, a method of preparing said solution, and the use of a solution of the invention, a solution prepared by a method of the invention, or a kit of the invention in predicting and/or diagnosing and/or monitoring a neurocognitive disorder of the Alzheimer's disease spectrum.

Abstract: The invention is a method for automatic detection of neurocognitive impairment, comprising, generating, in a segmentation and labelling step (11), a labelled segment series (26) from a speech sample (22) using a speech recognition unit (24); and generating from the labelled segment series (26), in an acoustic parameter calculation step (12), acoustic parameters (30) characterizing the speech sample (22).

Abstract: The invention relates to C-3 substituted kynurenic acid derivatives with the general formula (I) wherein R1 is C1-7alkyl-, R6R7N—C1-7alkyl-, C6-10aryl-C1-7alkyl group; R2 is H or C1-7alkyl group; or R1 and R2 with the nitrogen atom to which they are attached form a saturated or partially saturated 5-7 membered, optionally benzofused heterocyclic ring, optionally comprising additional N, O, S heteroatoms and optionally being substituted; R3 is —OH, C1-7alkyl-O—, —NH2, C1-7alkyl-NH—, C6-10aryl-C1-7alkyl-NH— or —NH— —(CH2)n—NR8R9 group wherein n is an integer from 1 to 3; R4 is H, C1-7alkyl-, C6-10aryl group or a halogen atom; R5 is H or C6-10aryl group; R6 is C1-7alkyl group; R7 is C1-7alkyl group; or R6 and R7 with the nitrogen atom to which they are attached form a saturated or partially saturated 5-7 membered, optionally benzofused heterocyclic ring, optionally comprising additional N, O, S heteroatoms and optionally being substituted; R8 is C1-7alkyl group; R9 is C1-7alkyl group; R8 and R9 with the nitrogen

Abstract: The present invention relates to nanocomposites for the controlled delivery of active ingredients into the central nervous system. The nanocomposite according to the present invention comprises a biocompatible core part comprising biodegradable material, and polyelectrolytes able to form a electrostatic van der Waals interactions with the material of the core part. The core part of the nanocomposite is able to bind various pharmaceutical agents. The present invention also relates to a process for the preparation of the nanocomposite according to the present invention and to the use of the nanocomposite according to the present invention.

Abstract: The subject matter of the invention is a communication method comprising the establishment of a communication route to a target partner not reachable by direct addressing by by-passing a node blocking the direct connection, further comprising the steps of setting up a TURN server at one or more users of the communication network in response to a definite and pre-granted request or in advance, and implementing the communication route to be established via at least one mentioned TURN server, with the effective mutual authorization management of the users involved in the communication session.

Abstract: The invention deals with chromogenic media which are suitable for the selective growth and identification of one or more species of yeast. The subject of the invention is the method that enables us to identify and determine the cell count of Brettanomyces/Dekkera and Zygosaccharomyces yeasts. Besides, the subjects of invention are also the use of the method in wine and/or food industry and the stocks for conducting the experiment.

Abstract: The invention relates to the use of pharmaceutical compositions containing as the active agent a compound of formula I in the treatment of dermal wounds. The compositions may be used for the promotion of healing of wounds affecting the deeper layers under the epithelium, including dermal- and sub dermal connective tissue, being cut, punctured, sliced wounds or originating in insufficient tissue perfusion, chronic diseases or other harms. The compositions are formulated for local application and may comprise other active agents contributing to wound healing in addition to a compound of formula (I).

Abstract: The invention relates to a gel composition comprising 0.6 to 2.5 weight percent of guar gum, 0.01 to 0.05 weight percent of boric acid, 0.003 to 0.007 weight percent of a base, 2.5 to 4.5 weight percent of a short carbon chain alcohol, optionally 0.01 to 0.5 weight percent of additives and the necessary amount of water to reach 100% weight. The invention covers a method for producing the gel composition and the use thereof.

Abstract: A method for tracking the movement and trajectory of objects associated with wireless devices, located in a predefined area, wherein transceiver nodes communicating with the monitored wireless communication devices are formed, the objects associated with wireless communication device entering or located in the range of the transceiver nodes are detected by said transceiver nodes and relevant collected data are processed by measuring the strength of the signal emitted by the object during communication by at least two access points, converting the measured signal strength data into a vector set, selecting and filtering out the objects that are communicating but make no movement by evaluating the vector set, and analyzing the movement of the communicating objects changing their place by applying a pre-defined mathematical model. Access points operating according to a small-range “peer-to-peer” (P2P) type wireless communication standard are used as transceiver nodes.

Abstract: A biological material is disclosed for exerting antagonism against the mushroom pathogen Pseudomonas bacteria, which contains the Pseudomonas synxantha PS54 bacterium strain deposited under # NCAIM (P) B 001387 according to the Budapest treaty. The biological material according to the invention is an effective antagonist against the pathogens of mushrooms, in particular oyster mushrooms and/or champignons, in particular Pseudomonas tolaasii and Pseudomonas agarici. Furthermore, the invention relates to a composition comprising a culture of the biological material according to the invention, the use of the invention for the protection of mushrooms, and a process for controlling pathogens. The invention further relates to an agent for producing mushrooms, which agent has been contacted with the biological material according to the invention.

Abstract: The invention relates to new morphine derivatives deuterated at the 7,8-position of the morphine ring, furthermore to a process for the preparation thereof, and to pharmaceutical compositions comprising them. The new deuterated morphine derivatives show high and selective ?-opioid receptor binding activity leading to the benefit of higher analgesic activity at lower dosages inducing thereby reduced adverse effects compared to the hydrogenated derivatives. The compounds of the invention are useful for example in the treatment of pain or can be used as antitussive agents with a reduced risk of the possibility of drug abuse.

Abstract: A method for tracking the movement and trajectory of objects associated with wireless devices, located in a predefined area, wherein transceiver nodes communicating with the monitored wireless communication devices are formed, the objects associated with wireless communication device entering or located in the range of the transceiver nodes are detected by said transceiver nodes and relevant collected data are processed by measuring the strength of the signal emitted by the object during communication by at least two access points, converting the measured signal strength data into a vector set, selecting and filtering out the objects that are communicating but make no movement by evaluating the vector set, and analysing the movement of the communicating objects changing their place by applying a pre-defined mathematical model. Access points operating according to a small-range “peer-to-peer” (P2P) type wireless communication standard are used as transceiver nodes.

Abstract: A distributed data mining method to be carried out in user equipments connected to a peer-to-peer communication network. The method includes: providing a data mining frame application in the equipments as code running on a device-specific platform and a trainable data mining algorithm produced on a programming language common to all equipments, running the data mining algorithm in a first equipment to process user data stored therein, modifying the data structures and/or the input parameter set of the data mining algorithm through training, forwarding at least a part of the modified input parameter set and/or the modified data structures of the data mining algorithm as training information from the first equipment to at least one second equipment, and modifying the input parameter set and/or the data structures of the data mining algorithm running on at least one second equipment using the training information received from the first equipment.

Abstract: The subject matter of the invention is a communication method comprising the establishment of a communication route to a target partner not reachable by direct addressing by by-passing a node blocking the direct connection, further comprising the steps of setting up a TURN server at one or more users of the communication network in response to a definite and pre-granted request or in advance, and implementing the communication route to be established via at least one mentioned TURN server, with the effective mutual authorisation management of the users involved in the communication session.

Abstract: A biological material is disclosed for exerting antagonism against vegetable pathogens, which contains Bacillus mojavensis R3B mutant strain deposited under # NCAIM (P) B 001389 according to the Budapest Treaty. The biological material according to the invention is an effective antagonist against the pathogens of vegetables, preferably tomato, pepper, lettuce and/or cabbage, in particular against the pathogens selected from the group of Xanthomonas vesicatoria, Pseudomonas syringae and Clavibacter michiganensis vegetable pathogen bacteria and Pythium debaryanum, Phytophthora infestans, Alternaria alternata and Fusarium oxysporum vegetable pathogen fungi.

Abstract: The invention deals with chromogenic media which are suitable for the selective growth and identification of one or more species of yeast. The subject of the invention is the method that enables us to identify and determine the cell count of Brettanomyces/Dekkera and Zygosaccharomyces yeasts. Besides, the subjects of invention are also the use of the method in wine and/or food industry and the stocks for conducting the experiment.

Abstract: The invention relates to a pharmaceutical composition comprising a compound selected from the group consisting of desethylamiodarone and pharmaceutically acceptable salts, hydrates and solvates thereof, together with pharmaceutically acceptable excipients, vehicle and/or carrier, as well as the pharmaceutical composition for use in the treatment and prevention of atrial fibrillation with fewer side effects than its parent compound.

Abstract: The invention relates to a tonometric device (20) for examination of respiratory insufficiency and regional tissue perfusion failure in patients, comprising a distal end (22), a section (24) to be introduced into the body, and a fixing part (3). The section (24) to be introduced comprises a first tube (1) to which an additional tubing (4) is connected. A second tube (2) is arranged substantially parallel with the first tube (1). At least the section (24) of the first tube (1) is made of a material permeable for gases, especially for carbon' dioxide, but substantially impermeable for body fluids, preferably of silicone rubber. The device does not comprise any balloon, it can be introduced into the patient stomach without preliminary preparation, and is useful for examination of premature babies.