Patents Assigned to T Cell Diagnostics, Inc.
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Patent number: 5811525Abstract: The invention relates to the measurement of total leukocyte antigens, or fragments thereof, and the use of such measurements to enumerate cells, especially in whole blood. The term "total" leukocyte antigen used herein refers to the total amount of a leukocyte antigen in a sample, including that present in membrane and intracellular compartments and extracellular soluble compartments. Measurements of a total leukocyte antigen can be used to type cells, detect or diagnose disease or to monitor disease therapy. In a further embodiment, the invention relates to the measurement of both the amount of total leukocyte antigen and the amount of the soluble form of the leukocyte antigen and a comparison of the measured levels.Type: GrantFiled: May 1, 1995Date of Patent: September 22, 1998Assignee: T Cell Diagnostics, Inc.Inventor: Charles W. Rittershaus
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Patent number: 5747265Abstract: The invention is directed to methods and a device for detecting or measuring the amount of a cell-associated molecule in a biological fluid sample. Cell-associated molecules which can be detected or measured include, but are not limited to, cell surface antigens, intracellular cytokines, microbial antigens, pharmacological agents or their metabolites, and nucleic acids. In the preferred embodiment, a sample of whole blood is collected on filter paper and dried. A dot is punched form the dried blood spot and the analyte of interest eluted from the paper with a buffered, relatively highly concentrated detergent solution. The eluate is then assayed in a standard assay, such as an immunoassay.Type: GrantFiled: May 14, 1993Date of Patent: May 5, 1998Assignee: T Cell Diagnostics, Inc.Inventors: George H. Parsons, Margaret A. Johns, Arthur E. Rugg
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Patent number: 5525461Abstract: The invention relates to the measurement of total leukocyte antigens, or fragments thereof, and the use of such measurements to enumerate cells, especially in whole blood. The term "total" leukocyte antigen used herein refers to the total amount of a leukocyte antigen in a sample, including that present in membrane and intracellular compartments and extracellular soluble compartments. Measurements of a total leukocyte antigen can be used to type cells, detect or diagnose disease or to monitor disease therapy. In a further embodiment, the invention relates to the measurement of both the amount of total leukocyte antigen and the amount of the soluble form of the leukocyte antigen and a comparison of the measured levels.Type: GrantFiled: May 6, 1993Date of Patent: June 11, 1996Assignee: T Cell Diagnostics, Inc.Inventor: Charles W. Rittershaus
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Patent number: 5426029Abstract: The present invention is directed to the measurement of soluble leukocyte surface markers, soluble T cell growth factor receptors, soluble complement receptors, soluble T cell differentiation antigens, or related soluble molecules or fragments thereof, and the use of such measurements in the diagnosis and therapy of diseases and disorders. The invention is also directed to the measurement of soluble CD35 (sCD35) or fragments thereof, and the use of such measurements in detecting disease or disorders. A polyclonal sandwich assay is provided for the detection and/or measurement of soluble CD35. The invention further relates to the measurement of total leukocyte markers or fragments thereof, and the use of such measurements in the detection and diagnosis of diseases or disorders. The term "total" leukocyte marker used herein refers to the total amount of a leukocyte marker in a sample, including that present in membrane and intracellular compartments and extracellular soluble compartments.Type: GrantFiled: November 7, 1990Date of Patent: June 20, 1995Assignee: T Cell Diagnostics, Inc.Inventors: Charles W. Rittershaus, Wei-Tao Tian, Patrick C. Kung
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Patent number: 5292636Abstract: The present invention is directed to the measurement of soluble T cell growth factor receptors, soluble T cell differentiation antigens, or related soluble molecules or fragments thereof, and the use of such measurements in the diagnosis, staging, and therapy of diseases and disorders. Specific embodiments involve the diagnosis and monitoring of therapy using absolute values of such soluble molecules. Further embodiments involve detecting a change in the levels of such soluble molecules, in the diagnosis and therapy of diseases and disorders. In specific embodiments, measurements of interleukin-2 receptor levels can be made to detect lung cancer, or to stage squamous cell lung carcinoma. In other embodiments, detection of increases in both soluble IL2R and creatinine in the body fluid of a transplant patient can be used to differentially diagnose renal allograft rejection from infection.Type: GrantFiled: November 9, 1989Date of Patent: March 8, 1994Assignee: T Cell Diagnostics, Inc.Inventors: Patrick C. Kung, Stephen H. Ip, Michael C. Brown, Linda A. MacKeen
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Patent number: 5286653Abstract: The present invention provides purified polypeptides which comprise at least a portion of a .delta.T cell receptor polypeptide, a .gamma.T cell receptor polypeptide or a .gamma.,.delta. T cell receptor complex. Substances capable of forming complexes with these polypeptides are also provided. Additionally, methods for detecting T cells which have within them or on their surfaces a polypeptide of the present invention are provided. Moreover, methods for diagnosing immune system abnormalities are provided which comprise measuring in a sample from a subject the number of T cells which have within them or on their surfaces a polypeptide of the present invention.Type: GrantFiled: July 3, 1986Date of Patent: February 15, 1994Assignees: T Cell Diagnostics, Inc., Dana Farber Cancer Institute, President and Fellows of Harvard CollegeInventors: Michael B. Brenner, Jack L. Strominger, Jonathan Seidman, Stephen H. Ip, Michael S. Krangel
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Patent number: 5260223Abstract: The present invention provides purified polypeptides which comprise at least a portion of a .delta. T cell receptor polypeptide, a .gamma. T cell receptor polypeptide, a .gamma., .gamma. T cell receptor complex or a .gamma., .delta. T cell receptor complex. Substances capable of forming complexes with these polypeptides are also provided.Additionally, methods for detecting T cells which have within them or on tThis invention was supported by several NIH grants, and the Government has certain rights to the invention.Type: GrantFiled: April 29, 1988Date of Patent: November 9, 1993Assignees: President & Fellows of Harvard College, Dana Farber Cancer Institute & T Cell Diagnostics, Inc.Inventors: Michael B. Brenner, Jack L. Strominger, John G. Seidman, Stephen H. Ip, Michael S. Krangel