Abstract: A combination and method for treatment and metaphylaxis of urate and mixed urate lithiasis is disclosed. The active component of the invention is a non-ionogenic surfactant of the formula R-COO(CH.sub.2 CH.sub.2 O).sub.n H, wherein R is linolic acid, linolenic acid, or oleinic acid, and n is a number from 18 to 40. The active component forms a complex water-soluble compound with uric acis, thereby dissolving urate calculi and eliminating uric acid from the urine. The invention exhibits rapid and reliable therapeutic effect, without side effects, and without reliance on maintenance of urine pH.

Abstract: The invention relates to penicillin derivatives of Formula I, and a method of synthesis; the derivatives having high antimicrobial activity against gram-positive and gram-negative microorganisms. ##STR1## R is selected from the group consisting of ##STR2## R.sub.1 is selected from the group consisting of hydrogen and a hydroxyl group;R.sub.2 is selected from the group consisting of hydrogen, an alkaline metal, and a carboxy protective group;R.sub.3 is selected from the group consisting of hydrogen, a lower alkyl, and a phenyl residue;R.sub.4, R.sub.5, and R.sub.6 are each selected from the group consisting of hydrogen, a halogen, a lower alkyd, and a lower alkoxy group;A is selected from the group consisting of oxygen and a N-(lower alkyl) residue; andn is 0 or 1.

Abstract: The invention relates to tetrahydroisoquinoline derivatives of the Formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each selected from the group consisting of a hydrogen and a hydroxyl group. These derivatives are useful in tocology (obstetrics).Administration of the inventive compounds induces relaxation of uterine muscles, a property that is particularly useful in cases of second trimester miscarriage, premature birth up to the 37th or 38th week of pregnancy, and during delivery. The compounds are especially useful from the onset of labor up to delivery of the newborn's head, a period which is often accompanied or complicated by frequent, violent, uncoordinated contractions of the uterus. The compounds are also useful in obstetric and gynecological operations, such as a hysterectomy, surgery for acute placental insufficiency, etc.