Patents Assigned to Taichung Veterans General Hospital
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Patent number: 11937932Abstract: An acute kidney injury predicting system and a method thereof are proposed. A processor reads the data to be tested, the detection data, the machine learning algorithm and the risk probability comparison table from a main memory. The processor trains the detection data according to the machine learning algorithm to generate an acute kidney injury prediction model, and inputs the data to be tested into the acute kidney injury prediction model to generate an acute kidney injury characteristic risk probability and a data sequence table. The data sequence table lists the data to be tested in sequence according to a proportion of each of the data to be tested in the acute kidney injury characteristics. The processor selects one of the medical treatment data from the risk probability comparison table according to the acute kidney injury characteristic risk probability.Type: GrantFiled: July 8, 2022Date of Patent: March 26, 2024Assignees: TAICHUNG VETERANS GENERAL HOSPITAL, TUNGHAI UNIVERSITYInventors: Chieh-Liang Wu, Chun-Te Huang, Cheng-Hsu Chen, Tsai-Jung Wang, Kai-Chih Pai, Chun-Ming Lai, Min-Shian Wang, Ruey-Kai Sheu, Lun-Chi Chen, Yan-Nan Lin, Chien-Lun Liao, Ta-Chun Hung, Chien-Chung Huang, Chia-Tien Hsu, Shang-Feng Tsai
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Patent number: 11925457Abstract: A device for encouraging and guiding a spirometer user includes a housing, a main valve, a visual assembly, and a sound making assembly. The housing has a guiding channel, a first outlet channel, a second outlet channel, and an inlet channel. The main valve is disposed in a housing communicating with the guiding channel, the first outlet channel, the second outlet channel or the inlet channel and configured to regulate or control fluid flowing paths. The visual assembly includes a check valve in the second outlet channel, and at least one movable member. The sound making assembly includes a check valve and a sound maker. So, it can generate the visual and sound encouraging effects for learning how to use a spirometer correctly.Type: GrantFiled: February 17, 2021Date of Patent: March 12, 2024Assignees: TAICHUNG VETERANS GENERAL HOSPITAL, CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Ming-Feng Wu, Yu-Hsuan Chen, Kuo-Chih Su, Chun-Hsiang Wang
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Patent number: 11908136Abstract: A respiratory status classifying method is for classifying as one of at least two respiratory statuses and includes an original physiological parameter inputting step, an original chest image inputting step, a characteristic physiological parameter generating step, a characteristic chest image generating step, a training step and a classifier generating step. The characteristic chest image generating step includes processing at least a part of the original chest images, segmenting images of a left lung, a right lung and a heart from each of the original chest images that are processed, and enhancing image data of the images being segmented, so as to generate a plurality of characteristic chest images. The training step includes training two respiratory status classifiers using a plurality of characteristic physiological parameters and the characteristic chest images by at least one machine learning algorithm.Type: GrantFiled: September 27, 2022Date of Patent: February 20, 2024Assignees: TAICHUNG VETERANS GENERAL HOSPITAL, TUNGHAI UNIVERSITYInventors: Ming-Cheng Chan, Kai-Chih Pai, Wen-Cheng Chao, Yu-Jen Huang, Chieh-Liang Wu, Min-Shian Wang, Chien-Lun Liao, Ta-Chun Hung, Yan-Nan Lin, Hui-Chiao Yang, Ruey-Kai Sheu, Lun-Chi Chen
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Publication number: 20230196737Abstract: An image recognition method and an electronic apparatus configured for image recognition are provided. A training sample set is provided to train a recognition model including neural networks to recognize a classification label to which an image to be tested belongs through the trained recognition model. The training sample set includes image sets respectively belonging to users. During the training process, training images corresponding to classification labels are obtained from a first image set in the training sample set as reference images for training; a training image is obtained from a second image set different from the first image set as an input image for training; the reference images for training and the input image for training are obtained as inputs to the neural networks for training. The input to each neural network includes at least one of the reference images for training and the input image for training.Type: ApplicationFiled: December 13, 2022Publication date: June 22, 2023Applicants: Industrial Technology Research Institute, Taichung Veterans General HospitalInventors: Yu-An Chiou, Yueh-Se Li, Shih-Fang Yang Mao, Wen-Cheng Chao, Sou-Jen Shih, Shu-Fang Liu, Hui-Jiun Chen, Chieh-Liang Wu
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Patent number: 11524296Abstract: A circulating tumor cell capture device includes a chip system and a pump. The chip system includes a confluence chip and a lower chip set. The lower chip set is disposed at a lower surface of the confluence chip, and includes a channel chip, a split chip and a porous membrane. The channel chip is disposed at the lower surface of the confluence chip. The split chip is detachably stacked below the channel chip. The porous membrane is embedded in the channel chip. The specimen passes through the porous membrane and flow between the channel chip and the split chip to make the circulating tumor cell be captured by the porous membrane.Type: GrantFiled: January 30, 2020Date of Patent: December 13, 2022Assignees: NATIONAL TSING HUA UNIVERSITY, TAICHUNG VETERANS GENERAL HOSPITALInventors: Hsuan-Yo Mu, Jen-Huang Huang, Tzu-Hung Hsiao
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Patent number: 11047012Abstract: The present invention discloses a new biomarker miR-134, miR-223, or IL-18, which is positively correlated with AOSD and activities thereof. By detecting the expression level of at least one biomarker in a sample, an effect of detecting the risk and prognosis of a sample provider suffering from a disease is achieved.Type: GrantFiled: June 21, 2018Date of Patent: June 29, 2021Assignee: TAICHUNG VETERANS GENERAL HOSPITALInventors: Tsai-Ling Liao, Der-Yuan Chen
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Patent number: 10980470Abstract: The present invention discloses an allergy detection chip, a preparation method thereof, and a method for detecting allergy therewith. The allergy detection chip comprises a substrate; a plurality of nanoprojections, disposed on a surface of the substrate; a plurality of gold nanoparticles, disposed on the surface of the substrate comprising the nanoprojections; a plurality of linkers, attached to the surface of each of the gold nanoparticles at one end respectively; and a plurality of antibodies, having a carboxyl end of a heavy chain covalently bonded to the other end of each of the linkers respectively. By means of the allergy detection chip disclosed in the present invention, whether a patient has high risk of allergy can be quickly detected, so as to reduce the risks faced by the patients and the healthcare personnel.Type: GrantFiled: March 19, 2018Date of Patent: April 20, 2021Assignee: TAICHUNG VETERANS GENERAL HOSPITALInventors: Ping-Wing Lui, Chin Hui Shen
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Patent number: 10920225Abstract: This present invention discloses an antisense oligonucleotide for splicing adjustment of mutant dopa decarboxylase gene which is complementary to SEQ ID NO: 1. This antisense oligonucleotide can modulate alternative splicing site of mutant dopa decarboxylase gene. It is helpful to research and develop drug to treat AADC deficiency symptom. This present invention also discloses a method to use said antisense oligonucleotide in vitro.Type: GrantFiled: May 3, 2017Date of Patent: February 16, 2021Assignee: TAICHUNG VETERANS GENERAL HOSPITALInventors: Chi-Ren Tsai, Ching-Shiang Chi, Hsiu-Fen Lee
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Patent number: 10835622Abstract: The invention is a simplified model on kidney rejection in animals and its setting approach. The method involves isolating dendritic cells from male mice and isolating T cells from female mice and then using the naive T cells in vitro to culture concurrently with male dendritic cells. Those activated T cells from female origin were injected into renal cortex in male mice for the purpose of attacking renal cortex. The animal model simulates the renal transplant rejection method to enable effective induction of renal transplant immune reaction.Type: GrantFiled: August 8, 2017Date of Patent: November 17, 2020Assignees: NATIONAL YANG-MING UNIVERSITY, TAIPEI VETERANS GENERAL HOSPITAL, TAICHUNG VETERANS GENERAL HOSPITALInventors: Der-Cheng Tarng, Nien-Jung Chen, Shuo-chun Weng
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Patent number: 10621722Abstract: The present invention disclosed an iterative analyzing method, which can detect the lesion in the image quickly. In brief, the iterative analysis method of the medical image disclosed by the present invention is roughly as follows: first, the original spectral image cube is expanded into a spectral image cube by a method of nonlinear dimensional-expansion, and then detecting the target's subpixel by the method of constrained energy minimization to produce an abundance image; the abundance image is fed back to the spectral image cube for create another spectral image cube by the nonlinear method. Furthermore, the abundance image is only used for detecting the subpixel of the target and does not include any spatial information, so, in order to obtain the spatial information of spectral image, it obtains the spatial information around the subpixel by using a blurring tool such as a Gaussian filter.Type: GrantFiled: July 10, 2018Date of Patent: April 14, 2020Assignee: TAICHUNG VETERANS GENERAL HOSPITALInventors: Chein-I Chang, Chi-Chang Clayton Chen, Jyh Wen Chai, Hsian-Min Chen
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Patent number: 10441612Abstract: The present invention discloses a method for treating and/or preventing metabolic syndrome and related diseases thereof, by administering a microbe composition to an individual to achieve the modulation of blood glucose, inhibition of body weight gain, reduction of low density cholesterol in blood, and reduction of hepatic expression of inflammatory factors, thereby effectively treating and/or preventing metabolic syndrome or related diseases thereof.Type: GrantFiled: August 16, 2016Date of Patent: October 15, 2019Assignee: TAICHUNG VETERANS GENERAL HOSPITALInventor: Chun-Ying Wu
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Patent number: 10379123Abstract: The present application discloses a THLW peptide, an amino acid sequence of which is represented by SEQ ID No. 1. The THLW peptide can be used as a biomarker for diseases, such as oral cancer and cervical cancer, etc., relating to infection of human papilloma virus (HPV), therefore, THLW peptide as an antigen or an anti-THLW peptide antibody prepared can be used to detect the risk of developing cancer for sample providers.Type: GrantFiled: October 25, 2017Date of Patent: August 13, 2019Assignees: TUNGCHAI UNIVERSITY, TAICHUNG VETERANS GENERAL HOSPITALInventors: Feng-Di Lung, Ye-song Gu, Bor-rung Ou, Chi-Sheng Cheng, Man-Yee Chan
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Patent number: 8911482Abstract: An interlocking bone plate system includes an outer bone plate for being arranged outside a broken bone, an inner bone plate for being installed inside the medullary cavity of the broken bone, and screws for being inserted through and engaged with the outer bone plate and the broken bone and then engaged with the inner bone plate so as to interlock the out and inner bone plates together. The inner bone plate provides an added support in addition to the support provided by the outer bone plate, enhancing the structural strength of the whole bone fixation structure and lowering the risk of failed surgery.Type: GrantFiled: March 13, 2012Date of Patent: December 16, 2014Assignee: Taichung Veterans General HospitalInventors: Cheng-Hung Lee, Chih-Han Chang, Chih-Kun Hsiao, Kui-Chou Huang, Chih-Hui Chen
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Patent number: 8865165Abstract: This present invention discloses a monoclonal antibody which specifically recognizes and binds to a epitope of group 2 allergen of Dermatophagoides pteronyssiuns, usually named Der p 2, and a hybridoma cell line producing thereof. Furthermore, this invention also discloses a strip, kit and method utilizing said monoclonal antibody for the detection of the presence of dust mite allergens and the calculation of dust mite number in the environment.Type: GrantFiled: November 15, 2012Date of Patent: October 21, 2014Assignee: Taichung Veterans General HospitalInventors: En-Chin Liao, Jaw-Ji Tsai
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Publication number: 20140287939Abstract: The present invention discloses the nine biomarkers including HIF1A, FAM84B, CRIP2, GSN, RPL15, DLG1, MAT2A, PGBD2 and ID3 are respectively selected according to their specific and unique expression profile in the gastric cancer cells or gastric cancer tissue. Therefore, the nine biomarkers are related to diagnose gastric cancer, such as detecting early gastric cancer, staging gastric cancer, predicting prognosis of gastric cancer and diagnosing lymph node metastasis. By analyzing the expression value of at least one biomarker of a sample from a subject, the subject can be precisely diagnose the risk about gastric cancer.Type: ApplicationFiled: September 24, 2013Publication date: September 25, 2014Applicant: Taichung Veterans General HospitalInventor: Chun-Ying WU
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Publication number: 20140260698Abstract: A transparent liquid suction measuring device comprises a conduit portion, a main body, and a suction generating portion. Liquid can be sucked into the main body via the conduit portion. The main body comprises a chamber to accommodate the liquid. The chamber has many inward projecting elements, a corresponding area, and many outward projecting elements. The inward projecting elements occupy an inward projecting volume that is compensated by an outward projecting volume formed by the outward projecting elements. So, an accommodating volume of the chamber is constantly maintained. When the inward projecting elements are visually observing from a corresponding area through the chamber, magnifying effect is generated. These outward projecting elements can be observed to acquire the liquid volume. Therefore, the advantages includes magnifying scales through liquid lens effects, having a compensation design to maintain measuring accuracy, and having a rough structure to make scales much visually obvious.Type: ApplicationFiled: March 12, 2013Publication date: September 18, 2014Applicant: TAICHUNG VETERANS GENERAL HOSPITALInventor: Ming-Feng WU
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Publication number: 20140113964Abstract: The present invention discloses a method of preventing and treating allergic airway diseases via intranasal gabexate mesilate, comprising administrating a pharmaceutically effective amount of a composition comprising a gabexate mesilate via nasal spray to prevent and treat allergy induced by a serine protease type allergen.Type: ApplicationFiled: October 23, 2012Publication date: April 24, 2014Applicant: TAICHUNG VETERANS GENERAL HOSPITALInventors: MEY-FANN LEE, YI-HSING CHEN, CHIA-WEI CHANG
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Publication number: 20130345076Abstract: This invention provides probes, chip, kit and method for detection the species of Mycobacterium tuberculosis (MTB), non-tuberculosis mycobacteria (NTM) and drug resistant of Mycobacterium tuberculosis. The purpose of this present invention is archived by hybridization reaction of said probes being selected from the group consisting of SEQ ID NO: 3˜23 and 26˜36. Efficient and one-step detection for determining the species of NTM, MTB and drug resistance of MTB is achieved via hybridization of probes with specific DNA fragments in MTB, NTM and MTB B acquiring drug resistance potency.Type: ApplicationFiled: March 18, 2013Publication date: December 26, 2013Applicant: TAICHUNG VETERANS GENERAL HOSPITALInventors: Gwan-Han SHEN, Tzu-Ting CHANG
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Publication number: 20130143242Abstract: This present invention discloses a monoclonal antibody which specifically recognizes and binds to a epitope of group 2 allergen of Dermatophagoides pteronyssiuns, usually named Der p 2, and a hybridoma cell line producing thereof. Furthermore, this invention also discloses a strip, kit and method utilizing said monoclonal antibody for the detection of the presence of dust mite allergens and the calculation of dust mite number in the environment.Type: ApplicationFiled: November 15, 2012Publication date: June 6, 2013Applicant: TAICHUNG VETERANS GENERAL HOSPITALInventor: Taichung Veterans General Hospital
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Patent number: 8449835Abstract: A devise for fecal occult blood test comprises a first and a second casings, a sampling portion extending from the first casing, a specimen processing portion, at least a testing portion and a packing cylindrical member. The packing cylindrical member is coupled between the first and second casings when unused and dismantled therefrom when used. After sampling via a specimen collecting portion of the sampling portion, the specimen collecting portion is drawn into the first casing to reduce the device size. The first and second casings are fixedly coupled together in a specimen processing position thereof to mix specimens with a liquid of the specimen processing portion into a testing liquid, and then in a specimen testing position thereof to disperse onto the testing portions for testing and directly display test results. The present invention advantages high accuracy, rather hygiene, significant size reduction, real-time testing-result display and convenient use.Type: GrantFiled: October 3, 2011Date of Patent: May 28, 2013Assignee: Taichung Veterans General HospitalInventor: Ming-Feng Wu