Patents Assigned to TAIWAN MITOCHONDRION APPLIED TECHNOLOGY CO.,LTD.
-
Publication number: 20230143850Abstract: The embodiments according to the present disclosure provide a protective solution, a kit, and a method for isolating mitochondria. The kit includes an extraction tube, a protective solution, and a suction needle. The extraction tube is used to contain cells. The protective solution is used to mix with the cells in the extraction tube to form a mixture solution, and the osmolarity of the protective solution is greater than 0 and less than or equal to 220 mOsm/L. The suction needle is used to suck the mixed solution back and forth to facilitate the release of mitochondria from cells. This method and the protective solution may isolate mitochondria from cells with high efficiency in a simple and convenient way, and the isolated mitochondria have excellent good function.Type: ApplicationFiled: January 5, 2023Publication date: May 11, 2023Applicant: TAIWAN MITOCHONDRION APPLIED TECHNOLOGY CO., LTD.Inventors: Han-Chung CHENG, Chih-Kai HSU
-
Publication number: 20230085499Abstract: The composition for improving liver function of the present disclosure includes at least one of mitochondria from autologous cells and exogenous mitochondria, and stem cells. The composition may decrease GOT and GPT indices, indicating the composition of the present disclosure may repair damaged liver and improve the regeneration ability of the damaged liver. The composition of the present disclosure may improve albumin synthesis, prothrombin synthesis and bilirubin metabolism of the liver, indicating the composition of the present disclosure may improve liver's ability of synthesis and metabolism.Type: ApplicationFiled: November 8, 2022Publication date: March 16, 2023Applicant: TAIWAN MITOCHONDRION APPLIED TECHNOLOGY CO., LTD.Inventors: Han-Chung CHENG, Chih-Kai HSU, Chi-Tang TU, Shun-Chieh YANG, An-Ling CHENG
-
Publication number: 20230081868Abstract: A use of a ramie extract in preparing a composition for anti-aging is provided. The composition containing ramie extract can improve the function and activity of mitochondria and telomerase and protect mitochondria from oxidative stress, including decrease in the proton leakage, increase in the ATP production, increase in the spare respiratory capacity, increase in the maximal respiratory capacity, or increase in the ATP coupling efficiency.Type: ApplicationFiled: June 2, 2022Publication date: March 16, 2023Applicant: TAIWAN MITOCHONDRION APPLIED TECHNOLOGY CO., LTD.Inventors: Han-Chung CHENG, Shun-Chieh YANG, An-Ling CHENG
-
Publication number: 20230023438Abstract: The embodiments of the present disclosure provide a composition including mitochondria. By providing the mitochondria to cartilage, the composition can improve the mitochondrial function of the chondrocytes in the cartilage so as to increase the repair ability of the chondrocytes and repair the cartilage damage caused by aging of the chondrocytes, thereby achieving the purpose of treating osteoarthritis.Type: ApplicationFiled: September 19, 2022Publication date: January 26, 2023Applicant: TAIWAN MITOCHONDRION APPLIED TECHNOLOGY CO., LTD.Inventors: Han-Chung CHENG, Chih-Kai HSU, Shun-Chieh YANG, An-Ling CHENG, Chi-Tang TU
-
Publication number: 20230023218Abstract: The embodiments of the present disclosure provide a cell culture composition and a use thereof, and the cell culture composition includes a culture medium and mitochondria. The cell culture composition including mitochondria can promote cell growth and improve the function of the damaged or aged stem cells, thereby improving overall cell growth.Type: ApplicationFiled: September 19, 2022Publication date: January 26, 2023Applicant: TAIWAN MITOCHONDRION APPLIED TECHNOLOGY CO., LTD.Inventors: Han-Chung CHENG, Chih-Kai HSU, Hui-Ching TSENG, Shun-Chieh YANG, Chi-Tang TU, Szu-Ting LIU, Li-Hsin YAO
-
Publication number: 20230016499Abstract: The embodiments of the present disclosure provide a manufacturing method of mitochondria-rich plasma. The mitochondria-rich plasma can increase the cell viability of damaged cells, decrease the cellular senescence level, repair the oxidative damage of cells, and relieve the inflammation of hair follicles so as to achieve the purpose of promoting hair regrowth.Type: ApplicationFiled: September 20, 2022Publication date: January 19, 2023Applicant: TAIWAN MITOCHONDRION APPLIED TECHNOLOGY CO., LTD.Inventors: Han-Chung CHENG, Chih-Kai HSU, Hui-Ching TSENG, An-Ling CHENG
-
Publication number: 20230003625Abstract: An agent for cryopreservation includes trehalose, HEPES and serum albumin. The agent for cryopreservation does not include potassium chloride, sodium chloride, ethylene glycol, ethylene glycol tetraacetic acid and ethylenediaminetetraacetic acid.Type: ApplicationFiled: August 26, 2022Publication date: January 5, 2023Applicant: TAIWAN MITOCHONDRION APPLIED TECHNOLOGY CO., LTD.Inventors: Chi-Tang TU, Szu-Ting LIU, Li-Hsin YAO, Han-Chung CHENG
-
Publication number: 20220168215Abstract: A composition with exogenous mitochondria as active ingredients, and a use thereof and a cell repairing method therefor. The composition includes exogenous mitochondria and at least one pharmaceutically or cosmetically acceptable carrier. The composition may further include an adjuvant, and the adjuvant is selected from a group consisting of serum, plasma, complement and at least the above two ingredients. The exogenous mitochondria are obtained from cells by a centrifugal purification method.Type: ApplicationFiled: February 15, 2022Publication date: June 2, 2022Applicant: TAIWAN MITOCHONDRION APPLIED TECHNOLOGY CO., LTD.Inventors: Hong-Lin SU, Hsueh-Min TSENG, Shih-Fang WU
-
Patent number: 10967019Abstract: A use of an emblica extract in preparing a pharmaceutical composition for protecting mitochondria in retina is provided. When the pharmaceutical composition, which comprises the emblica extract, is provided to retinal cells, a use of the pharmaceutical composition comprises improvement of the ability of performing the oxidative phosphorylation for the synthesis of the adenosine triphosphate (ATP) by the mitochondria in the retinal cells under or exposed to ultraviolet light, and improvement of the coupling efficiency of the synthesis of the adenosine triphosphate by the mitochondria.Type: GrantFiled: September 25, 2017Date of Patent: April 6, 2021Assignee: TAIWAN MITOCHONDRION APPLIED TECHNOLOGY CO., LTD.Inventors: Han-Chung Cheng, Chi-Tang Tu, Shun-Chieh Yang, Man-Ching Shen
-
Patent number: 10493105Abstract: A cell for treating neurodegenerative disease treated with angelica extract is provided. The pharmaceutical composition comprises the cell for treating neurodegenerative disease and can significantly increase and recover the number of dopaminergic neurons to achieve the goal for treating neurodegenerative disease.Type: GrantFiled: December 28, 2017Date of Patent: December 3, 2019Assignee: TAIWAN MITOCHONDRION APPLIED TECHNOLOGY CO., LTDInventors: Shinn-Zong Lin, Horng-Jyh Harn, Shih-Ping Liu, Han-Chung Cheng, Chi-Tang Tu
-
Patent number: 10420798Abstract: Disclosed are a novel pharmaceutical composition and use thereof, the novel pharmaceutical composition at least comprising an effective amount of mitochondria and at least one pharmaceutically acceptable carrier; the novel pharmaceutical composition is administered to an individual to send the mitochondria into injured or subject-to-oxidative-stress lung cells; thus treating or improving lung injury or related diseases thereof.Type: GrantFiled: December 31, 2014Date of Patent: September 24, 2019Assignee: TAIWAN MITOCHONDRION APPLIED TECHNOLOGY CO., LTDInventor: Hong-Lin Su
-
Patent number: 10342834Abstract: The present disclosure is related to a method for improving mitochondria in a cell, comprising step of treating the cell with an extraction of Emblica officinalis, for improving ability of mitochondria to perform oxidative phosphorylation and synthesize adenosine triphosphate. The present disclosure is also related to a method for promoting proliferation of a stem cell, comprising step of treating the stem cell with an extraction of Emblica officinalis, for improving division rate of the stem cell.Type: GrantFiled: January 8, 2019Date of Patent: July 9, 2019Assignee: TAIWAN MITOCHONDRION APPLIED TECHNOLOGY CO., LTD.Inventors: Han-Chung Cheng, Chi-Tang Tu, Szu-Ting Liu
-
Publication number: 20190142889Abstract: The present disclosure is related to a method for improving mitochondria in a cell, comprising step of treating the cell with an extraction of Emblica officinalis, for improving ability of mitochondria to perform oxidative phosphorylation and synthesize adenosine triphosphate. The present disclosure is also related to a method for promoting proliferation of a stem cell, comprising step of treating the stem cell with an extraction of Emblica officinalis, for improving division rate of the stem cell.Type: ApplicationFiled: January 8, 2019Publication date: May 16, 2019Applicant: TAIWAN MITOCHONDRION APPLIED TECHNOLOGY CO.,LTD.Inventors: Han-Chung CHENG, Chi-Tang TU, Szu-Ting LIU
-
Patent number: 10213467Abstract: The present disclosure is related to a method for improving mitochondria in a cell, comprising step of treating the cell with an extraction of Emblica officinalis, for improving ability of mitochondria to perform oxidative phosphorylation and synthesize adenosine triphosphate. The present disclosure is also related to a method for promoting proliferation of a stem cell, comprising step of treating the stem cell with an extraction of Emblica officinalis, for improving division rate of the stem cell.Type: GrantFiled: November 29, 2016Date of Patent: February 26, 2019Assignee: TAIWAN MITOCHONDRION APPLIED TECHNOLOGY CO., LTD.Inventors: Han-Chung Cheng, Chi-Tang Tu, Szu-Ting Liu
-
USE OF EMBLICA EXTRACT IN PREPARING PHARMACEUTICAL COMPOSITION FOR PROTECTING MITOCHONDRIA IN RETINA
Publication number: 20180008657Abstract: A use of an emblica extract in preparing a pharmaceutical composition for protecting mitochondria in retina is provided. When the pharmaceutical composition, which comprises the emblica extract, is provided to retinal cells, a use of the pharmaceutical composition comprises improvement of the ability of performing the oxidative phosphorylation for the synthesis of the adenosine triphosphate (ATP) by the mitochondria in the retinal cells under or exposed to ultraviolet light, and improvement of the coupling efficiency of the synthesis of the adenosine triphosphate by the mitochondria.Type: ApplicationFiled: September 25, 2017Publication date: January 11, 2018Applicant: TAIWAN MITOCHONDRION APPLIED TECHNOLOGY CO.,LTD.Inventors: Han-Chung CHENG, Chi-Tang TU, Shun-Chieh YANG, Man-Ching SHEN -
Publication number: 20170340668Abstract: Disclosed are a novel pharmaceutical composition and use thereof, the novel pharmaceutical composition at least comprising an effective amount of mitochondria and at least one pharmaceutically acceptable carrier; the novel pharmaceutical composition is administered to an individual to send the mitochondria into injured or subject-to-oxidative-stress lung cells; thus treating or improving lung injury or related diseases thereof.Type: ApplicationFiled: December 31, 2014Publication date: November 30, 2017Applicant: Taiwan Mitochondrion Applied Technology Co., Ltd.Inventor: Hong-Lin SU
-
Publication number: 20170290763Abstract: A composition with exogenous mitochondria as active ingredients, and a use thereof and a cell repairing method therefor. The composition includes exogenous mitochondria and at least one pharmaceutically or cosmetically acceptable carrier. The composition may further include an adjuvant, and the adjuvant is selected from a group consisting of serum, plasma, complement and at least the above two ingredients. The exogenous mitochondria are obtained from cells by a centrifugal purification method.Type: ApplicationFiled: September 30, 2014Publication date: October 12, 2017Applicant: TAIWAN MITOCHONDRION APPLIED TECHNOLOGY CO., LTD.Inventors: Hong-Lin SU, Hsueh-Min TSENG, Shih-Fang WU
-
Patent number: 9738871Abstract: A method of extracting organelles from cells includes following process. A plurality of cells and a solution are mixed uniformly to obtain a mixture. The mixture is loaded into a container. The container is placed in a milling device comprising a miller and a mechanical power source connected to the miller. The miller is immersed into the mixture within the container. The mixture is milled by the miller to obtain a homogenized mixture, wherein a milling parameter is provided to the milling device, and the mechanical power source drives the miller according to the milling parameter. The homogenized mixture is centrifuged to obtain a supernatant. The supernatant is centrifuged to obtain a precipitate with a plurality of organelles. In the process that the mixture is milled by the miller, at least a part of the miller is kept in the mixture.Type: GrantFiled: September 3, 2015Date of Patent: August 22, 2017Assignee: TAIWAN MITOCHONDRION APPLIED TECHNOLOGY CO., LTD.Inventors: Chia-Wen Lin, Hsin-Ting Tsai, Han-Chung Cheng
-
Publication number: 20170151297Abstract: The present disclosure is related to a method for improving mitochondria in a cell, comprising step of treating the cell with an extraction of Emblica officinalis, for improving ability of mitochondria to perform oxidative phosphorylation and synthesize adenosine triphosphate. The present disclosure is also related to a method for promoting proliferation of a stem cell, comprising step of treating the stem cell with an extraction of Emblica officinalis, for improving division rate of the stem cell.Type: ApplicationFiled: November 29, 2016Publication date: June 1, 2017Applicant: TAIWAN MITOCHONDRION APPLIED TECHNOLOGY CO.,LTD.Inventors: Han-Chung CHENG, Chi-Tang TU, Szu-Ting LIU