Abstract: A protein and DNA encoding the same are useful as preventives/remedies for diseases such as hypoglycemia, etc. The protein of the present invention is also useful as a reagent for screening a compound that inhibits the binding of the protein of the present invention to IRAP (insulin responsive aminopeptidase) or to GLUT4 (glucose transporter 4). The compound that inhibits the binding of the protein of the present invention to IRAP or GLUT4 is useful as a preventive/remedy for diseases, e.g., hyperglycemia, diabetes mellitus, etc.
Abstract: Heat-labile vitamin D is dispersed in a basic polymer and an excipient readily soluble in an organic solvent to provide a pharmaceutical composition. The composition exhibits reduced isomerization, decomposition, and discoloration while showing excellent stability.
Abstract: Unsaturated aliphatic dinitriles such as fumaronitrile and maleonitrile can be produced in high yields by ammoxidation of C.sub.4 straight-chain hydrocarbons in the presence of a catalyst containing as active components:[A] at least one kind of oxides of vanadium and tungsten, and[B](1) at least one kind of oxides of antimony, phosphorus and boron, and/or(2) at least one kind of oxides of chromium, nickel, aluminum and silicon.
Abstract: Macbecin derivatives are produced by cultivating a microorganism of the genus Actinosynnema in a culture medium.The Macbecin derivatives are useful as antibacterial, antifungal or antiprotozoal agent.