Patents Assigned to Takeda Chemical Insustries, Ltd.
  • Composition for prophylaxis or treatment of pulmonary circulatory diseases
    Patent number: 5753619
    Abstract: Cyclic hexapeptides having antagonistic activity on endothelin receptors of the formula ?I!: ##STR1## wherein X and Y each is an .alpha.-amino acid residue having D-, L-form or DL-form, A is a D-acidic-.alpha.-amino acid residue, B is a neutral-.alpha.-amino acid residue having D- or L-form, C is an L-.alpha.-amino acid residue and E is a D-.alpha.-amino acid residue having an aromatic ring group can be effectively used for prophylaxis and/or treatment of pulmonary circulatory diseases.
    Type: Grant
    Filed: November 29, 1995
    Date of Patent: May 19, 1998
    Assignee: Takeda Chemical Insustries, Ltd.
    Inventors: Toshifumi Watanabe, Keiji Kusumoto, Mitsuhiro Wakimasu