Abstract: The present invention is to provide a compound or a salt thereof represented by the formula: wherein R1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, the ring A is an optionally substituted divalent nitrogen-containing heterocyclic group, X′ is an optionally substituted alkylene chain, Y is an optionally substituted divalent cyclic group, X is a chemical bond or an optionally substituted alkylene chain, and Z is (1) an optionally substituted amino group, (2) an optionally substituted imidoyl group or (3) an optionally substituted nitrogen-containing heterocyclic group, or a pro-drug thereof, which has activated coagulation factor X inhibitory activity and which are useful as anti-coagulants.

Abstract: The present invention relates to a novel protein belonging to an ADAM family, a partial peptide thereof or a salt thereof, a DNA encoding the protein, a recombinant vector comprising the DNA, a transformant, a method for producing the protein, a medicine comprising the protein or the DNA, an antibody against the protein, a method/kit for screening for a compound or a salt thereof which promotes or inhibits the protease activity or the extracellular metric degrading enzyme activity (preferably, the peptidoglycan degrading enzyme activity) of the protein, a compound obtained by the screening, and a medicine comprising the compound. The present protein and a DNA encoding it can be used, for example, as an agent for treating or preventing various diseases such as disc herniation, ischialgia, glomerular nephritis, diabetic nephropathy, hepatic fibrosis, pulmonary fibrosis or osteopetrosis. In addition, the present antibody can be used for quantitating the present protein in a test solution.

Abstract: An agent for improving ketosis which comprises an insulin sensitizer, which has an excellent action and low toxicity.

Abstract: To provide a method for producing polyester polyol that can provide a simple process to produce extensively improved production efficiencies and also produce the polyester polyol of stable in quality, an apparatus for producing the polyester polyol produced by the method, a polyester polyol produced by the method, and a polyurethane foam obtained by use of the polyester polyol produced by the method, polyethylene terephthalate and raw polyol are allowed to react in a reaction vessel to produce polyester polyol and also ethylene glycol which is a by-product of the reaction is distilled off and the distillate is modified in a modifying vessel so that it can have a predetermined hydroxyl value and then is fed to the reaction vessel again as the raw glycol, to thereby produce the polyester polyol.

Abstract: A novel crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole or a salt thereof of the present invention is useful for an excellent antiulcer agent.

Abstract: This invention provides a matrix adhering to the nasal mucosa which allows improved transfer into the brain of a drug exerting its effect in the brain and is capable of continuously supplying the drug into the brain. This matrix contains a polyglycerol fatty acid ester, the drug exerting its effect in the brain, and a viscogenic substance.

Abstract: Apparatus for decomposing a polyurethane resin and recovering the decomposed polyurethane resin as a polyamine compound and a polyol compound. The apparatus includes a first reactor that decomposes the polyurethane resin as the target compound of hydrolysis decomposition; a second reactor that hydrolyzes the decomposed target compound of decomposition with either one of supercritical water and high-temperature high-pressure water to a decomposition product mixture; a water supplier that feeds either one of supercritical water and high-temperature high-pressure water to the second reactor; and a post-processor that causes the decomposition product mixture discharged from the second reactor to be subjected to a post treatment procedure, such as dehydration, addition, distillation, separation, and liquid separation to recover the polyamine compound and the polyol compound.

Abstract: The present invention provides thienopyridine derivatives, which are useful as anti-inflammatory drugs, particularly as remedies for arthritis; processes for producing them, and pharmaceutical compositions containing them. The thienopyridine derivatives are represented by the formula (I): wherein G is a halogen atom, hydroxyl group, an optionally substituted amino group, etc.; alk is an optionally substituted lower alkylene group; X is O, S, —(CH2)q—, etc.; R is an optionally substituted amino group, etc.; ring B is an optionally substituted Y-containing 5- to 8-membered ring whose ring constituent atoms contain no nitrogen atom; Y is O, S, a group of (wherein Ra, Rb and Rc are the same or different and, each is H, a halogen atom, an optionally substituted hydrocarbon group, etc.), etc.; and ring A may be substituted.

Abstract: Imidazol-4-ylmethanols and their uses for preventing and treating primary tumors, metastasis and recurrence of tumors, various symptoms accompanying tumors, prostatic hypertrophy, virilism, hirsutism, male pattern alopecia, precocious puberty, endometriosis, uterine myoma, mastopathy and polycystic ovary syndrome are disclosed.

Abstract: The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula 1

Abstract: An insecticide application to termites is obtained comprising at least one member selected from a plant, an extract of the plant, and an ooze (or exudate) of the plant, wherein the plant belongs to at least one genus selected from the group consisting of the genus Geranium, the genus Morus, the genus Artemisia, the genus Diospyros, the genus Crataegus, the genus Curcuma, the genus Rubia, the genus Polygonum, the genus Gardenia, the genus Cornus, the genus Uncaria, the genus Rheum, the genus Terminalia and the genus Saussurea. The extract may be a substance extracted with at least one member selected from the group consisting of water and a hydrophilic solvent. The insecticide exhibits high insecticidal and insect-controlling activity against insects (e.g., sanitarily injurious insects, insects injurious to houses and particularly to timber such as termites), being highly safe to human beings and animals and not adversely affecting the environment.

Abstract: Disclosed are (1) a human luteinizing hormone-human chorionic gonadotropin receptor protein, (2) a DNA comprising a CDNA segment coding for a human luteinizing hormone-human chorionic gonadotropin receptor protein, SEQ ID NO:2 (3) a transformant carrying a DNA comprising a cDNA segment SEQ ID NO:1 coding for a human luteinizing hormone-human chorionic gonadotropin receptor protein, and (4) a method for preparing a human luteinizing hormone-human chorionic gonadotropin receptor protein which comprises cultivating the transformant described in (3), accumulating a protein SEQ ID NO:2 in a culture broth, and collecting the same, whereby the structure and properties of the receptor protein are made clear and the mass production thereof by recombinant technology is pioneered.

Abstract: This invention relates to glutamine:fructose-6-phosphate amidotransferase, or its partial peptide or a salt thereof; a DNA coding for the protein; a recombinant vector; a transformant; a method for producing the protein; a pharmaceutical composition comprising the protein, its partial peptide or a salt thereof; and an antibody against the protein or its partial peptide. The protein, its partial peptide or a salt thereof, and the DNA are useful for a prophylactic or therapeutic agent for hypoglycemia. The antibody can be used in the assay of the protein, its partial peptide or a salt thereof. The protein, its partial peptide or a salt thereof is useful as a reagent for the screening for candidate medical compounds.

Abstract: This invention relates to an optically active benzothiepin derivative represented by the formula: wherein R represents a lower alkyl group; R1 and R2 independently represent a lower alkyl group, or may bind together to form a ring, which exhibits excellent osteogenesis-promoting action and is useful as a prophylactic or therapeutic drug for bone diseases.

Abstract: A process for hydrolyzing and recycling polyurethanes as target compounds to be hydrolyzed into raw materials or derivatives thereof for the target compounds, comprising bringing pressurized water in a liquid state at a temperature of 190 to 370° C. into contact with the target compounds in a reactor to hydrolyze the target compound; followed by post-processings, such as dewatering, addition, distillation, separation, and liquid separation for a hydrolyzed reaction product discharged from the reactor.

Abstract: A condensed pyridazine derivative which is useful as a pharmaceutical composition for preventing or treating allergic skin diseases such as contact dermatitis, pruritus, dried dermatitis, acute urticaria and prurigo.

Abstract: Compounds of general formula (1) R1—X1—W—X2—Z1—Z2—R2 or salts thereof, exhibiting preventive and therapeutic effects against HIV infectious diseases wherein R1 is an optionally substituted five- or six-membered ring group; X1 is a free valency or the like; W is a divalent group represented by, e. g., general formula (2) (wherein A and B are each an optionally substituted five- to seven-membered ring; E1 and E4 are each optionally substituted carbon or the like; E2 and E3 are each oxygen or the like; and a and b are each a single bond or a double bond); X2 is a divalent group constituting a straight chain moiety; Z1 is a divalent cyclic group or the like; Z2 is a free valency or the like; and R2 is optionally substituted amino or the like.

Abstract: A pharmaceutical composition for antagonizing adenosine at adenosine A3 receptors which comprises a 1,3-azole compound substituted on the 4- or 5-position, or both, by a pyridyl which may be substituted is provided and can be used as a prophylactic and therapeutic agent for asthma, allergosis, inflammation, and so on.

Abstract: This invention provides new benzoxazepine compounds represented by the formula: [wherein R stands for a lower alkyl group optionally substituted with a hydroxyl group, X stands for an optionally substituted carbamoyl group or an optionally substituted heterocyclic group having a deprotonatable hydrogen atom, R1 stands for a lower alkyl group and W stands for a halogen atom] having activities of lowering cholesterol-level and lowering trigluceride-level, and being useful for prophylaxis and therapy of hyperlipidemia.

Abstract: A compound of the formula: wherein Ar is an aromatic ring assembly group which may be substituted or a fused aromatic group which may be substituted; X is (i) a bond, (ii) —S—, —SO— or —SO2—, (iii) C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene, etc.