Patents Assigned to Takeda Pharmaceutical Company Limited
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Publication number: 20240139317Abstract: The invention relates to COnditional Bispecific Redirected Activation constructs, or COBRAs, that are administered in an active pro-drug format. Upon exposure to tumor proteases, the constructs are cleaved and activated, such that they can bind both tumor target antigens (TTAs) as well as CD3, thus recruiting T cells expressing CD3 to the tumor, resulting in treatment.Type: ApplicationFiled: July 21, 2023Publication date: May 2, 2024Applicant: Takeda Pharmaceutical Company LimitedInventors: Chad May, Robert B. DuBridge, Maia Vinogradova, Anand Panchal
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Publication number: 20240142468Abstract: Provided herein are methods and kits for analyzing a biological sample obtained from a subject having, suspected of having, or being at risk for a disease associated with the contact activation system.Type: ApplicationFiled: October 4, 2023Publication date: May 2, 2024Applicant: Takeda Pharmaceutical Company LimitedInventors: Daniel J. Sexton, Malini Viswanathan, Ryan Faucette, Tripti Gaur
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Patent number: 11969703Abstract: An antibody-resin coupling apparatus quickly and efficiently activates resin beads and couples them to antibodies, while preventing breakdown and crosslinking of the beads, thereby improving downstream column purification processes, extending the usable life of the resin beads, and increasing molecule capture efficiency of the resultant resin-antibody complexes, to allow improved isolation and purification of factor VIII molecules or other drug compounds.Type: GrantFiled: September 16, 2021Date of Patent: April 30, 2024Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Robert Toso, Richard Spanggord, Mei Tan, Van Taiariol, Yekaterina Lin
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Patent number: 11970483Abstract: The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the formula (I): wherein R1 is a hydrogen atom, a halogen atom, an optionally substituted C1-6 alkyl group, or an optionally substituted C1-6 alkoxy group; and ring A is an optionally further substituted ring, or a salt thereof.Type: GrantFiled: September 27, 2019Date of Patent: April 30, 2024Assignee: Takeda Pharmaceutical Company LimitedInventors: Shinobu Sasaki, Yasutomi Asano, Kazuaki Takami, Masaki Seto, Haruhi Ando
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Publication number: 20240124593Abstract: The disclosure relates to antibodies that bind FcRn and methods of using these antibodies.Type: ApplicationFiled: July 6, 2023Publication date: April 18, 2024Applicant: Takeda Pharmaceutical Company LimitedInventors: Daniel J. Sexton, Christopher TenHoor, Malini Viswanathan
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Publication number: 20240125767Abstract: The present invention provides drug toxicity evaluation platforms (such as an evaluation method and a kit therefor) that enable detailed analysis of the possibility and the like of developing drug-induced damage (such as DILI) to the liver and other organs. The method for evaluating drug toxicity of the present invention includes: a step of adding a drug to a co-culture system of an organoid and blood cells; and a step of evaluating the toxicity of the drug to the organoid.Type: ApplicationFiled: October 16, 2020Publication date: April 18, 2024Applicants: Public University Corporation Yokohama City University, Takeda Pharmaceutical Company LimitedInventors: Takanori TAKEBE, Norikazu SAIKI
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Patent number: 11957684Abstract: Methods for treating uterine fibroids, endometriosis, adenomyosis, or heavy menstrual bleeding in a subject, which include administering to the subject from 10 mg to 60 mg per day of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N?-methoxyurea, and from 0.01 mg to 5 mg per day of a hormone replacement medicament. The present disclosure has methods for reducing menstrual bleeding in a subject, reducing bone mineral density loss in a subject caused by administering a GnRH antagonist to the subject, suppressing sex hormones in a subject, reducing vasomotor symptoms or hot flashes in a subject, and reducing symptoms of decreased libido in a subject having uterine fibroids, endometriosis, or adenomyosis.Type: GrantFiled: July 15, 2022Date of Patent: April 16, 2024Assignees: Sumitomo Pharma Switzerland GmbH, Takeda Pharmaceutical Company LimitedInventors: Brendan Mark Johnson, Lynn Seely, Paul N. Mudd, Jr., Susan Wollowitz, Mark Hibberd, Masataka Tanimoto, Vijaykumar Reddy Rajasekhar, Mayukh Vasant Sukhatme
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Patent number: 11959100Abstract: As a technique for proliferating neural crest cells without reducing differentiation capacity, provided is a method for producing neural crest cells, comprising the steps of: (1) obtaining neural crest cells; and (2) suspension-culturing the neural crest cells in a medium comprising a GSK3? inhibitor and a basic fibroblast growth factor (bFGF), wherein the medium comprises the GSK3? inhibitor with a concentration that exhibits an effect equivalent to that exhibited by CHIR99021 with a concentration of higher than 1 ?M and lower than 5 ?M.Type: GrantFiled: November 29, 2018Date of Patent: April 16, 2024Assignees: Kyoto University, Takeda Pharmaceutical Company LimitedInventors: Makoto Ikeya, Yayoi Kamiya
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Patent number: 11957867Abstract: A syringe stabilizing apparatus has a base and a syringe support. The syringe support is vertically disposed above the base, elevating a fluid-filled portion of an infusion set vertically above the base and orienting a delivery end of the fluid-filled portion upwardly relative to a horizontal plane to take advantage of a gravitational effect on a fluid during delivery of the fluid from the fluid-filled portion to a patient. The syringe support comprises a first retainer and a selectively actuated tube clamp. The first retainer has an opening in which a rigid portion of the infusion set is received and retained therein without further user intervention. The selectively actuated tube clamp is operatively aligned with the first retainer. A flexible tube extending from the rigid portion of the infusion set extends through the selectively actuated tube clamp.Type: GrantFiled: June 26, 2017Date of Patent: April 16, 2024Assignee: Takeda Pharmaceutical Company LimitedInventors: Scott Richard Ariagno, Angela Teresa Muriset, Daniel Edward Roush, Denise A. Alexander, Madeleine Clare Gibson, Gin-Fu Chen
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Patent number: 11958845Abstract: The present invention provides a heterocyclic compound having a HDAC6 inhibitory action, which is useful for the treatment of central nervous system diseases including neurodegenerative diseases, and the like, and a medicament comprising the compound. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.Type: GrantFiled: September 26, 2022Date of Patent: April 16, 2024Assignee: Takeda Pharmaceutical Company LimitedInventors: Masahiro Ito, Hideyuki Sugiyama, Takeshi Yamamoto, Keiko Kakegawa, Jinxing Li, Junsi Wang, Takahito Kasahara, Masato Yoshikawa
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Patent number: 11958850Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.Type: GrantFiled: August 31, 2021Date of Patent: April 16, 2024Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Wei-Sheng Huang, Yongjin Gong, Feng Li, Nicholas E. Bencivenga, David C. Dalgarno, Anna Kohlmann, William C. Shakespeare, Ranny M. Thomas, Xiaotian Zhu, Angela V. West, Willmen Youngsaye, Yun Zhang, Tianjun Zhou
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Publication number: 20240117346Abstract: In an embodiment, an object of the present invention is to provide a double-stranded nucleic acid complex having a novel structure. In an embodiment, the present invention relates to a nucleic acid complex comprising a first nucleic acid strand and a second nucleic acid strand, wherein said first nucleic acid strand: (1) is capable of hybridizing to at least a part of a target transcriptional product; (2) has an antisense effect on the target transcriptional product; and (3) is a gapmer comprising a central region, and a 5? wing region and a 3? wing region, said second nucleic acid strand comprises at least one sugar-unmodified central region (first exposed region) consisting of one sugar-unmodified ribonucleoside or two or three contiguous sugar-unmodified ribonucleosides linked by an internucleoside bond, which is or are complementary to a part of said first nucleic acid strand, and said first nucleic acid strand is annealed to said second nucleic acid strand.Type: ApplicationFiled: October 9, 2020Publication date: April 11, 2024Applicants: National University Corporation Tokyo Medical and Dental University, Takeda Pharmaceutical Company LimitedInventors: Takanori Yokota, Tetsuya Nagata, Hiroki Yamada, Hideki Furukawa, Takatoshi Yogo, Kenichi Miyata, Akio Uchida, Naoki Tomita
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Patent number: 11952344Abstract: Provided is a heterocyclic compound that can have an antagonistic action on an NMD A receptor containing the NR2B subunit and that is expected to be useful as a prophylactic or therapeutic agent for depression, bipolar disorder, migraine, pain, peripheral symptoms of dementia and the like. A compound represented by the formula (I), wherein each symbol is as defined in the DESCRIPTION, or a salt thereof.Type: GrantFiled: September 25, 2020Date of Patent: April 9, 2024Assignee: Takeda Pharmaceutical Company LimitedInventors: Yuya Oguro, Makoto Kamata, Shuhei Ikeda, Takeshi Wakabayashi, Norihito Tokunaga, Taku Kamei, Mitsuhiro Ito, Shigemitsu Matsumoto, Hirotaka Kamitani, Takaharu Hirayama, Toshio Tanaka, Hiroshi Banno, Nobuyuki Takakura, Jinichi Yonemori, Takuya Fujimoto
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Patent number: 11939327Abstract: The present invention aims to provide a heterocyclic compound having an AMPA receptor potentiator effect, which is expected to be useful as an agent for the prophylaxis or treatment of depression, Alzheimer's disease, schizophrenia, attention deficit hyperactivity disorder (ADHD) and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof.Type: GrantFiled: August 15, 2022Date of Patent: March 26, 2024Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Tomoaki Hasui, Shinji Nakamura, Satoshi Mikami, Tohru Yamashita
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Patent number: 11938174Abstract: Compositions and methods useful for the treatment of neuromyelitis optica (NMO) or neuromyelitis optica spectrum disorder (NMOSD) are disclosed.Type: GrantFiled: September 11, 2020Date of Patent: March 26, 2024Assignee: Takeda Pharmaceutical Company LimitedInventors: Colin Broom, Jeffrey Dayno
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Publication number: 20240091414Abstract: The invention provides, inter cilia, ultra-thin conformal coated biological surfaces, such as living cells, cell clusters, tissues, organs, and hybrid synthetic organs, and methods of making the same, e.g., using click reactive water soluble polymers, under conditions that do not damage or significantly modify the biological surfaces. In some embodiments, the coated biological surfaces are suitable for delivery to a subject in need thereof.Type: ApplicationFiled: July 19, 2023Publication date: March 21, 2024Applicant: Takeda Pharmaceutical Company LimitedInventors: Venkata R. Garigapati, Tetsuya Matsuura
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Publication number: 20240082479Abstract: Containers for one or more fluid delivery systems are disclosed.Type: ApplicationFiled: November 22, 2021Publication date: March 14, 2024Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Jeffrey PELTIER, Peter MURPHY, Eugene CANAVAN
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Patent number: D1018556Type: GrantFiled: March 31, 2021Date of Patent: March 19, 2024Assignee: Takeda Pharmaceutical Company LimitedInventor: Stefano De Socio
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Patent number: D1023287Type: GrantFiled: March 17, 2022Date of Patent: April 16, 2024Assignee: Takeda Pharmaceutical Company LimitedInventors: John Kenneth Hainsworth, Matthew John Garwood, Matthew Ian Murchie, Hong Choo Tang, Fabian Ghoshal
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Patent number: D1023288Type: GrantFiled: March 17, 2022Date of Patent: April 16, 2024Assignee: Takeda Pharmaceutical Company LimitedInventors: John Kenneth Hainsworth, Matthew John Garwood, Matthew Ian Murchie, Hong Choo Tang, Jason Robinson