Abstract: This invention relates to a novel method and a device for quantitative concentration measurements of protein bound and middle sized uremic toxins and advanced glycation end-products in the biological fluids, preferably in the spent dialysate. Invention combines unique spectral ranges of fluorescence and absorption to determine concentration of uremic toxins, such as indoxyl sulphate, beta-2-microglobulin and 4-pyridoxic acid in a way that provides significantly higher precision than previously known solutions.

Abstract: Microfluidic method and device that can be used for sensing and measurement of properties of liquids, gases, solutions, and particles is proposed, wherein the measurable liquid or gas (with or without particles) flow in at least one channel through a measurement chamber (cell) formed between at least two isolated electrodes is used for electrical impedance measurement. The proposed solution is characterized in that the cross-section of at least one pair of similar spatial electrodes decreases smoothly towards the tiny measurement chamber (cell) in order to increase the sensitivity and accuracy of the measurement. Typically, a device with multiple similar channels is advantageous to use for comparative measurement and differential measurement schemes.

Abstract: Disclosed is a system for objective self-assessment of physical capabilities and condition changes of individuals with conditions like multiple sclerosis, the system has a mobile device with an appropriate software for carrying out a set of tests for assessment of motor capabilities such as body balance, muscle strength, and muscle spasticity, and receiving assessment feedback. The system has inertial motion sensors for performing motion sensing, wherein said inertial motion sensors are integrated with said mobile device, e.g., a smartphone, a smart watch, or a personal computer, or in a separate wearable sensor device, connected with said mobile device over wired or wireless data connection. Also disclosed is a method for such self-assessment with such system.

Abstract: The present invention relates to a sensor for the detection of Neurotrophic Factor (NF). The sensor, preferably a Screen Printed Electrochemical sensor (SPE), has a working electrode coated by a Molecularly Imprinted Polymer (MIP) imprinted by a NF. The invention also relates to a method for preparing such a sensor and comprising the steps of 1) formation of a cleavable linking layer on the working electrode of the sensor; 2) immobilization of NF molecules on the cleavable linking layer; 3) polymerization of m-PD on the working electrode of the sensor; and 4) cleavage of the cleavable linking layer thereby removing the NF molecules from the MIP layer.

Abstract: A composite shielding material in the form of syntactic foam where the spherical or spherical-like articles are encompassed by an organic or inorganic matrix material, and coated with a layer of nanostructures such as carbon nanotubes, graphene, graphene flakes. Such articles may be alternatively or additionally be covered with nano-sized metal particles and the mould is filled with organic or inorganic matrix, and micro and/or nano-sized reinforcement elements. Such material possesses both reflective and absorptive properties to improve shielding effectiveness. Also process for making the same is disclosed. The composite material can be used as an electromagnetic, thermal or acoustic shield.

Abstract: The invention is related to the field of measurement electronics and related to the measurement of complex transfer functions (e.g. of impedance), especially in the presence of large disturbances and for measuring of small changes of the characteristics of the object under test. The goals of the proposed invention are achieved by detuning of the excitation and reference signals, e.g. by adding incremental phase-shift to the excitation signal to generate the reference signal.

Abstract: Microfluidic method and device that can be used for sensing and measurement of properties of liquids, gases, solutions, and particles is proposed, wherein the measurable liquid or gas (with or without particles) flow in at least one channel through a measurement chamber (cell) formed between at least two isolated electrodes is used for electrical impedance measurement. The proposed solution is characterized in that the cross-section of at least one pair of similar spatial electrodes decreases smoothly towards the tiny measurement chamber (cell) in order to increase the sensitivity and accuracy of the measurement. Typically, a device with multiple similar channels is advantageous to use for comparative measurement and differential measurement schemes.

Abstract: A method and device for high speed broadband testing of systems and substances using a binary, spectrally sparse sequence (SSS) as a periodic excitation waveform. The sequences with controllable frequency and magnitude spectra content are designed by component manipulation method or by edge manipulation method. The excitation waveform is typically pre-calculated, and kept in waveform memory, from where it is shifted out into digital to physical quantity converter (DQC). The sparse spectrum of the SSS makes it easy to create plenty of uncorrelated frequency sets with adjacent, but sufficiently different frequencies to form multi-path test systems, where all the paths can be measured simultaneously. The response of the sample under test (SUT) is sampled and the complex transfer function is calculated directly or indirectly via Impulse Response by Discrete Fourier Transform technique and its derivatives. The sequence bit interval and sampling interval have a predetermined ratio.

Abstract: A method for calorimetric determination of the lipoprotein lipase activity in human plasma comprising steps of preparing a reagent, obtaining and preparing human plasma sample, filling the isothermal titration calorimetry cell withe prepared human plasma sample, injecting LPL to the cell from the syringe-stirrer, changing the heat rate as a result of injection of LPL into ITC cell with human plasma, increasing LPL concentration in the ITC cell by at least one injection, performing isothermal titration calorimetry measurements, recording total hydrolysis of plasma lipids by LPL, recording differences in how well LPL can get access to the lipids, determing the influence of added regulators on the LPL reaction in plasma.

Abstract: Self-aligned fibrous scaffolds are disclosed. The scaffolds are capable of automechanoinduction of cell cultures and methods to induce authomechanoinduction in cancer cells and stem cells are disclosed as well.

Abstract: Sensor device and method for determining the parameters of fluid flow with a sensor, including an oblong element, extending into fluid flow, fixed mechanically to the body of the sensor device with a flexible link in one end, and a mechanically connected vibration sensor and a data acquisition module connected electrically to the vibration sensor and positioned in the body, which is set to determine the frequency response curve of oscillation caused by liquid flow in the cylindrical element, and to derive the speed and type of fluid flow from the measured frequency response curve.

Abstract: Method and device for impedance analyzer with binary excitation with improved accuracy, where the non-idealities of the sampling and preprocessing of the response signal (including aliasing effects) are taken into account by using of the overall system model with equivalent circuit diagrams of the analyzed object and the model of the preliminary analysis of the response signal. The analysis result is the equivalent circuit diagram with component values with the best match of the overall model analysis and of the preliminary analyze of the response signal. Further, the analysis result can be the impedance frequency characteristic or the classifier of the analyzed object. It could be reasonable to use the pre-calculated function (e.g. in the form of the look-up-table) for matching the results of the over-all model against the preliminary analyzed results of the response signal.

Abstract: Bioreactor system and method for cloning the physiological state of microorganisms comprises in preferred embodiment of a mother-reactor and one or more daughter-reactors with sensors, stirrers, fluid and gas flow channels, scales, pumps, controllers, computer, software, valves and accessory devices. The bioreactors are inter-connected with culture transfer hose. To achieve the method, the mother-reactor is filled with necessary volume, inoculated, stabilised in continuous cultivation, the microbial culture's volume is increased in variable volume cultivation while maintaining constant physiology, microbial culture is transferred from the mother-reactor into the daughter-reactors while maintaining constant physiology, experiment in the daughter reactor follows. After the experiment daughter-reactors are sterilized and rinsed.

Abstract: Method and device for acquiring stream of the precisely time-stamped images, including the modulated light source, controlled by the absolute global real-time-base (e.g. provided by global navigation satellite system (GNSS) controller) and the image acquisition and processing unit, decoding the light modulation waveform and determining the time-stamp for every image frame. The GNSS time and position messages can be used to provide the full time- and location stamps for each frame. Multi-element light sources can be used to have more informative light modulation in the time domain. For time-stamping of several image streams (e.g. from several cameras) multiple light sources with the same modulation can be used.

Abstract: Self-aligned fibrous scaffolds are disclosed. The scaffolds are capable of automechanoinduction of cell cultures and methods to induce authomechanoinduction in cancer cells and stem cells are disclosed as well.

Abstract: This invention belongs into the field of power electronics and semiconductor converter control and pertains to the method of shoot-through generation for modified sine wave Z-source, quasi-Z-source and trans-Z-source inverters. The inverter can be controlled using either the modified sine wave pulse-width modulation or phase-shift modulation method. There are three methods for shoot-through generation in the case of modified sine wave control: by overlapping active states, during the freewheeling state and during the zero state. To equalize switching losses in the case of unsymmetrical switching patterns, control signals of upper and lower switching elements are periodically interchanged.

Abstract: This invention relates to a novel method and a device for determining middle and protein bound uremic toxins in the biological fluids. More specifically, the present invention relates to an optical method utilizing fluorescence, preferable fluorescence of the spent dialysate, and a specific model, including a unique set of optical spectral components at certain wavelengths, to determine, preferable on-line, the concentration of the middle and protein bound uremic toxins such as beta2-microglobulin (B2M), and indoxyl sulfate (IS).

Abstract: The invention relates to the method of preparation of compounds of formula I, the precursors of homocitric acid lactone and its salts, by coupling of the compounds of formula II with bromoacetic acid esters of formula III.

Abstract: A method is provided for measuring a frequency response of an object, the method involving: generating an excitation signal having relatively fast changing frequency, defined by a time-domain function; generating at least one reference signal, having a waveform corresponding to the excitation signal; introducing the excitation signal into the object, receiving a response signal from the object; analyzing said response signal in a signal analyzer by correlating the response signal with at least one reference signal during a relatively short sliding time-domain window.

Abstract: A method and device are provided for fast impedance measurement of a biological object having dynamically varying in time parameters, wherein a titlet shaped pulse is introduced into the object and a voltage response signal is measured and analyzed by a processing unit for estimating the impedance of the object. The titlet pulse has a start frequency substantially in one end of the frequency range of interest and a stop frequency substantially in the other end of the frequency range of interest and a duration of the titlet pulse is one cycle or less.