Abstract: Cyclooctene conjugates of therapeutic or diagnostic agents have improved aqueous solubility and can release the agents upon contact with a tetrazine-containing biomaterial. The cyclooctene conjugates provide site-selective delivery of agents at the location of the tetrazine-containing biomaterial in a subject. The compositions and methods have applications in the treatment of various diseases or conditions including cancer, tumor growths, and bacterial infections.
Type:
Grant
Filed:
April 16, 2025
Date of Patent:
April 28, 2026
Assignees:
Tambo, Inc., The Research Foundation for the State University of New York
Inventors:
Jose Manuel Mejia Oneto, Nathan Yee, Maksim Royzen, Sangeetha Srinivasan, Ethan Miller
Abstract: 6-(Carbonyloxy)-1-methylcyclooct-4-ene-1-carbonyl)-aspartic acid conjugate of monomethyl auristatin E may be used for bioorthogonal delivery to a targeted location in a subject in the treatment of cancer and tumor growths.
Type:
Grant
Filed:
August 6, 2021
Date of Patent:
March 31, 2026
Assignee:
Tambo, Inc.
Inventors:
Jose Manuel Mejia Oneto, Nathan A. Yee, Jesse M. McFarland
Abstract: The present disclosure provides bioorthogonal compositions for delivering agents in a subject. The disclosure also provides methods of producing the compositions, as well as methods of using the same.
Abstract: Cyclooctene conjugates of therapeutic or diagnostic agents have improved aqueous solubility and can release the agents upon contact with a tetrazine-containing biomaterial. The cyclooctene conjugates provide site-selective delivery of agents at the location of the tetrazine-containing biomaterial in a subject. The compositions and methods have applications in the treatment of various diseases or conditions including cancer, tumor growths, and bacterial infections.
Type:
Grant
Filed:
December 14, 2021
Date of Patent:
May 13, 2025
Assignee:
Tambo, Inc.
Inventors:
Jose Manuel Mejia Oneto, Nathan Yee, Maksim Royzen, Sangeetha Srinivasan, Ethan Miller
Abstract: Cyclooctene conjugates of therapeutic or diagnostic agents have improved aqueous solubility and can release the agents upon contact with a tetrazine-containing biomaterial. The cyclooctene conjugates provide site-selective delivery of agents at the location of the tetrazine-containing biomaterial in a subject. The compositions and methods have applications in the treatment of various diseases or conditions including cancer, tumor growths, and bacterial infections.
Type:
Grant
Filed:
April 6, 2018
Date of Patent:
February 22, 2022
Assignees:
TAMBO, INC., THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
Inventors:
Jose Manuel Mejia Oneto, Nathan Yee, Maksim Royzen, Sangeetha Srinivasan, Ethan Miller
Abstract: The present disclosure provides bioorthogonal compositions for delivering agents in a subject. The disclosure also provides methods of producing the compositions, as well as methods of using the same.
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