Patents Assigned to Tanabe Seiyaku Co., Ltd
  • Indane derivative and processes for preparing the same
    Patent number: 5686452
    Abstract: Disclosed are an indane compound represented by the formula: ##STR1## wherein R.sup.1 represents a lower alkyl group, a lower alkenyl group or a substituted or unsubstituted mono-cyclic aromatic heterocyclic group having nitrogen atom as a hetero atom; R.sup.2 represents hydrogen atom or a lower alkyl group; and A represents a lower alkylene group,or a pharmaceutically acceptable salt thereof and processes for preparing the same.
    Type: Grant
    Filed: December 16, 1996
    Date of Patent: November 11, 1997
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Akihiko Ishida, Koichi Homma, Michihisa Yato, Shinsuke Nishiyama, Fumikazu Okumura
  • Baccatin derivatives and processes for preparing the same
    Patent number: 5677470
    Abstract: Disclosed are 13.alpha.-(3-substituted-2-hydroxypropionyloxy)baccatin compounds represented by the formula: ##STR1## wherein R.sup.1 represents a lower alkanoyl group or a protective group for hydroxy group; R.sup.2 represents a protective group for hydroxy group; R.sup.3 represents a lower alkanoyl group; R.sup.4 represents a substituted or unsubstituted benzoyl group; X represents a substituted or unsubstituted aryl group, a substituted or unsubstituted lower alkenyl group, or a substituted or unsubstituted lower alkynyl group; and A' represents a halogen atom, azido group or amino group,and processes for preparing the same.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 14, 1997
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Kenji Tsujihara, Tomiki Hashiyama, Naoyuki Harada, Kunihiko Ozaki, Motoaki Ohashi, Noriyuki Nakanishi, Tetsuo Yamaguchi
  • Pharmaceutical preparation comprising fat emulsion of fat microparticles
    Patent number: 5650172
    Abstract: A preparation comprising a fat emulsion of fat microparticles wherein said emulsion contains a stabilizer consisting essentially of a fatty acid, a basic amino acid and a saccharide is provided. In the preparation comprising a fat emulsion of fat microparticles of the present invention, said microparticles having a mean particle diameter of at most 100 nm are stable, and so the microparticles remain in blood without being uptaken by liver. Therefore in case of administering a pharmaceutical preparation prepared by using the above-mentioned preparation of the present invention, the pharmacological activity may be expressed at a desired site. Thus the preparation is extremely useful as a drug carrier for drug delivery system.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 22, 1997
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Saburo Matsuda, Shigeyuki Ishikawa, Akira Suzuki, Kenji Tsujihara, Motoaki Ohashi
  • Butadiene derivatives and process for using the same
    Patent number: 5639789
    Abstract: Novel butadiene derivatives of the formula [I]: ##STR1## wherein Ring A is tri-lower alkoxyphenyl, R.sup.1 and R.sup.2 combine each other to form a group of the formula: ##STR2## or one of R.sup.1 and R.sup.2 is lower alkoxy, and the other is group of the formula: -NHR.sup.3, in which R.sup.3 is hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted amino, hydroxy or pyridylcarbonyl, or salts thereof, these compounds have excellent antithrombotic activity and are useful as antithrombotic drug, or synthetic intermediate for preparing other antithrombotic drug.
    Type: Grant
    Filed: May 8, 1995
    Date of Patent: June 17, 1997
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Tameo Iwasaki, Takashi Nishitani, Akio Ohtani, Masanori Inamasu
  • Peripheral circulation improving agent
    Patent number: 5637582
    Abstract: There is disclosed (-)-cis-1,5-benzothiazepine represented by the following formula or pharmaceutically acceptable salt thereof: ##STR1## wherein R.sup.1 represents lower alkyl or lower alkoxy; R.sup.2 represents hydrogen or lower alkanoyl; R.sup.3 represents lower alkyl; R.sup.4 represents hydrogen or lower alkyl; R.sup.5 represent hydrogen, lower alkyl or hydroxy lower alkyl; and A represents lower alkylene,which is a prophylactic and/or curing agent of Raynaud's disease and chronic arterial obstruction.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: June 10, 1997
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Sakae Murata, Hiroshi Narita, Minako Kaburaki
  • Azetidinone compound and process for preparation thereof
    Patent number: 5631363
    Abstract: There is disclosed an azetidinone compound of the formula [I]: ##STR1## wherein Ring B is a benzene ring which may have substituent(s), R.sup.1 is a hydroxy-substituted lower alkyl group which may have substituent(s), X is oxygen atom and the like, Y is oxygen atom and the like, and Z is a methylene group which may have substituent(s), which is useful as a synthetic intermediate of the 1.beta.-methylcarbapenem-type antibacterial agent.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 20, 1997
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Tameo Iwasaki, Kazuhiko Kondo
  • Process for preparing 4-mercaptopyrrolidine intermediate compounds and a process for their use in preparing carbapenem -2-em-3 carboxylic acids
    Patent number: 5629419
    Abstract: An improved process for preparing a 4-mercaptopyrrolidine compound [I]: ##STR1## wherein R is H, lower alkyl or lower alkanoyl, R.sup.1 is H or SH-protecting group, and X is O or S, which comprises reacting halogenobutyric acid compound [VI], or a salt thereof, with amine compound [VII], or a salt thereof, and if necessary, followed by thiocarbonylating the product and/or removing the protecting group, said 4-mercaptopyrrolidine compound [I] being useful as intermediate for carbapenem antibacterial agents.
    Type: Grant
    Filed: November 8, 1995
    Date of Patent: May 13, 1997
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Hiroshi Ohmizu, Masahiko Seki, Takeshi Yamanaka
  • Pharmaceutical preparation controlled to release medicinal active ingredient at targeted site in intestinal tract
    Patent number: 5614220
    Abstract: A pharmaceutical preparation for oral administration comprising(a) a core containing a medicinal active ingredient,(b) a press-coated layer comprising a pH-independently water-soluble polymer, said layer being provided around the core and(c) a film comprising an enteric polymer, said film being provided around the press-coated layer. In the pharmaceutical preparation of the present invention, the medicinal active ingredient is not released during residence in the stomach and, after forwarded from the stomach, until reaching a targeted site in the intestine, and thereafter is quickly released, so that the medicinal active ingredient is efficiently delivered to the targeted site in the intestinal tract.
    Type: Grant
    Filed: February 9, 1995
    Date of Patent: March 25, 1997
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Yoshiyuki Hirakawa, Hiroyuki Yoshino, Katsuji Uemura, Eiji Fukui, Tami Hanamori
  • Baccatin derivatives and processes for preparing the same
    Patent number: 5608073
    Abstract: A compound represented by the formula [I]: ##STR1## wherein R.sup.3 represents a lower alkanoyl group; R.sup.4 represents a substituted or unsubstituted benzoyl group; ring A represents a substituted or unsubstituted cyclopropane ring; X represents a single bond or a group represented by --O--,--S-- or --NH--, R represents a substituted or unsubstituted lower alkyl group (wherein said lower alkyl group may have a cycloalkyl moiety), a substituted or unsubstituted aryl group or a substituted or unsubstituted aromatic heterocyclic group; E represents hydrogen atom or a group represented by --CO(CH.sub.2).sub.
    Type: Grant
    Filed: July 1, 1996
    Date of Patent: March 4, 1997
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Kenji Tsujihara, Tomiki Hashiyama, Motoaki Ohashi, Noriyuki Nakanishi
  • Indane derivatives, processes for preparing the same and synthetic intermediate of the same
    Patent number: 5605901
    Abstract: Disclosed are an indane compound represented by the formula: ##STR1## wherein R.sup.1 is aryl, lower alkyl, cycloalkyl, halogeno-lower alkyl, lower alkenyl, phenyl-substituted lower alkenyl, monocyclic or bicyclic aromatic heterocyclic having N, O or S as a hetero atom, lower alkoxy, phenoxy, lower alkylamino, lower alkenylamino, phenyl-amino, lower alkyl substituted by monocyclic or bicyclic aromatic heterocyclic having N, O or S as a hetero atom, or lower alkenyloxy; R.sup.2 is H or lower alkyl; X is carbonyl or thiocarbonyl; Alk is single bonding arm or lower alkylene; and the dotted line is presence or absence of a double bond, or a pharmaceutically acceptable salt thereof, processes for preparing the same and a synthetic intermediate thereof.
    Type: Grant
    Filed: December 28, 1994
    Date of Patent: February 25, 1997
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Akihiko Ishida, Koichi Homma, Michihisa Yato, Shinsuke Nishiyama, Fumikazu Okumura
  • Ellipticine derivative and process for preparing the same
    Patent number: 5605904
    Abstract: An ellipticine derivative of the formula [I]: ##STR1## wherein R is a substituted lower alkyl group, a substituted or unsubstituted lower alkoxy group or a heteromonocyclic group, or a pharmaceutically acceptable salt thereof, which show excellent antitumor activity, less side effects, less toxicity and/or high solubility in water and are useful as antitumor agent, and a process for preparing the same.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: February 25, 1997
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Kenji Tsujihara, Naoyuki Harada, Kunihiko Ozaki, Motoaki Ohashi, Koji Oda
  • Sustained release multi-core microsphere preparation and method for producing the same
    Patent number: 5603961
    Abstract: Sustained release multi-core microsphere preparation which shows high incorporation efficiency of medicament and can release the medicament at a specific rate, which comprises two or more biodegradable polymers and a pharmaceutically active ingredient, and has the medicament incorporated into microregions which are produced by one of these polymers (the first polymer), and these microregions are distributed in other biodegradable polymers (the second polymer), or a method for producing the same.
    Type: Grant
    Filed: September 30, 1993
    Date of Patent: February 18, 1997
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Takehiko Suzuki, Yukiko Nishioka, Yasuhisa Matsukawa, Akihiro Matsumoto, Masao Kobayashi
  • Baccatin derivatives and processes for preparing the same
    Patent number: 5589502
    Abstract: A compound represented by the formula [I]: ##STR1## wherein R.sup.3 represents a lower alkanoyl group; R.sup.4 represents a substituted or unsubstituted benzoyl group; ring A represents a substituted or unsubstituted cyclopropane ring; X represents a single bond or a group represented by --O--, --S-- or --NH--; R represents a substituted or unsubstituted lower alkyl group (wherein said lower alkyl group may have a cycloalkyl moiety), a substituted or unsubstituted aryl group or a substituted or unsubstituted aromatic heterocyclic group; E represents hydrogen atom or a group represented by --CO(CH.sub.2).sub.
    Type: Grant
    Filed: November 15, 1995
    Date of Patent: December 31, 1996
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Kenji Tsujihara, Tomiki Hashiyama, Motoaki Ohashi, Noriyuki Nakanishi
  • Process for preparing .beta.-lactam derivative and synthetic intermediate
    Patent number: 5589592
    Abstract: Disclosed is a process for preparing a .beta.-lactam compound represented by the formula: ##STR1## wherein R.sup.1 represents a hydroxy-substituted lower alkyl group or an amino group each of which may be protected; R.sup.2 represents hydrogen atom or an ester residue; X represents a methylene group which may be substituted by a lower alkyl group, sulfur atom or a group represented by the formula: --A--CH.sub.2 -- where A represents sulfur atom, oxygen atom or methylene group; and W represents an active ester residue of hydroxyl group,or a salt thereof, which comprises the steps of treating a 1-aza-3-thia-bicycloalkane compound represented by the formula: ##STR2## wherein R.sup.1, R.sup.2 and X have the same meanings as defined above, or a salt thereof with a base in the presence of a desulfurizing agent and then reacting the resulting compound with an active esterifying agent of hydroxyl group.
    Type: Grant
    Filed: April 7, 1995
    Date of Patent: December 31, 1996
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Hiroshi Horikawa, Kazuhiko Kondo
  • Benzenesulfonamide derivative and process for preparing thereof
    Patent number: 5589478
    Abstract: A benzenesulfonamide derivative of the formula [I]: ##STR1## wherein Ring A and Ring B are the same or different and each substituted or unsubstituted benzene ring, Q is a single bond or a group of the formula: --O--, --S--, --SO--, --SO.sub.2 -- or --CH2--, Y is a group of the formula: --O--, --S-- or --NH--, Alk is lower alkylene group or lower alkenylene group, Z is a single bond or a group of the formula: --O-- or --NH--, R is a substituted or unsubstituted aromatic heterocyclic or aryl group, R.sup.
    Type: Grant
    Filed: December 16, 1994
    Date of Patent: December 31, 1996
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Koichiro Yamada, K osuke Yasuda, Kohei Kikkawa, Rikako Kohno
  • Method for removing the protecting group for carboxyl group
    Patent number: 5587474
    Abstract: A method for removing substituted or unsubstituted allyl group from .beta.-lactam compound having substituted or unsubstituted allyl group-protecting carboxyl group, which comprises treating said .beta.-lactam compound with palladium catalyst in the presence of allyl-scavenger in aqueous organic solvent, by which the substituted or unsubstituted group can be easily and effectively removed under moderate conditions so that the desired compound can be obtained in high yield at low cost.
    Type: Grant
    Filed: June 17, 1993
    Date of Patent: December 24, 1996
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Kazuhiko Kondo, Hiroshi Horikawa, Tameo Iwasaki
  • Method for determining endotoxin and apparatus therefor
    Patent number: 5578455
    Abstract: There is disclosed a method for determining an endotoxin by reacting the endotoxin adsorbed on an adsorbent having specific endotoxin adsorbability with an endotoxin detecting reagent, including the steps of:(a) preparing a column having a tip opening, a rear end opening and an adsorbent-filling and holding means provided in the column through which a sample solution can pass,(b) introducing the endotoxin adsorbent into the column through the tip opening to fill and hold the adsorbent therein,(c) introducing the sample solution into the column through the tip opening and discharging the introduced sample solution through the rear end opening to contact the sample and the adsorbent and thereby adsorbing the endotoxin on the adsorbent, and(d) reacting the detecting reagent with the endotoxin adsorbed on the adsorbent.There is also disclosed an apparatus for the above method.
    Type: Grant
    Filed: March 14, 1994
    Date of Patent: November 26, 1996
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Tetsuya Tosa, Takeji Shibatani, Taizo Watanabe, Satoshi Minobe, Makoto Masuda
  • Ellipticine derivative and process for preparing the same
    Patent number: 5565569
    Abstract: An ellipticine derivative of the formula [I]: ##STR1## wherein R is a substituted lower alkyl group, a substituted or unsubstituted lower alkoxy group or a heteromonocyclic group,or a pharmaceutically acceptable salt thereof, which show excellent antitumor activity, less side effects, less toxicity and/or high solubility in water and are useful as antitumor agent, and a process for preparing the same.
    Type: Grant
    Filed: January 25, 1994
    Date of Patent: October 15, 1996
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Kenji Tsujihara, Naoyuki Harada, Kunihiko Ozaki, Motoaki Ohashi, Koji Oda
  • Method for producing sustained release microsphere preparation
    Patent number: 5556642
    Abstract: A method for producing sustained release microsphere preparation for water-soluble medicament, which has high incorporation efficiency of the medicament and low initial burst, which comprises dissolving water-soluble pharmaceutical active ingredient and water-insoluble biodegradable polymer in one or two solvents in which both can dissolve, removing the solvent to give a solid dispersion having the water-soluble pharmaceutical active ingredient dispersed into said biodegradable polymer at molecular level, and further, dissolving said solid dispersion in an organic solvent being water-immiscible and having a boiling point of below 100.degree. C., and adding the resulting oil phase into an aqueous phase containing emulsifying agent to give O/W emulsion, and followed by removing the organic solvent from the oil phase of the resulting emulsion.
    Type: Grant
    Filed: July 12, 1993
    Date of Patent: September 17, 1996
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Masao Kobayashi, Yukiko Nishioka, Takehiko Suzuki, Yashuhisa Matsukawa
  • Alkylation process for preparing azetidinone compound and starting compound therefor
    Patent number: 5550229
    Abstract: Novel process for preparing azetidinone compound of the formula [III]: ##STR1## wherein R.sup.1 is H or lower alkyl, R.sup.2 and R.sup.3 combine together with the adjacent nitrogen to form heterocyclic group, and R.sup.4 is protected or unprotected hydroxy-substituted lower alkyl, which comprises reacting an alkanamide compound of the formula [I]: ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are the same as defined above, with a compound of the formula [II]: ##STR3## wherein L.sup.1 is a leaving group and R.sup.4 is the same as defined above, in the presence of a base, said compound [III] being useful as synthetic intermediate for 1-methylcarbapenem derivative having excellent antibacterial activity.
    Type: Grant
    Filed: June 21, 1994
    Date of Patent: August 27, 1996
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Tameo Iwasaki, Kazuhiko Kondo, Hiroshi Ohmizu