Abstract: The present invention provides assay systems and methods for detection of copy number variation at one or more loci and polymorphism detection at one or more loci in a mixed sample from an individual.
Type:
Application
Filed:
August 8, 2011
Publication date:
February 9, 2012
Applicant:
TANDEM DIAGNOSTICS, INC.
Inventors:
Andrew Sparks, Craig Struble, Eric Wang, Arnold Oliphant
Abstract: The present invention provides assays systems and methods for detection of genetic variants in a sample, including copy number variation and single nucleotide polymorphisms. The invention preferably employs the technique of tandem ligation, i.e. the ligation of two or more fixed sequence oligonucleotides and one or more bridging oligonucleotides complementary to a region between the fixed sequence oligonucleotides.
Type:
Application
Filed:
January 25, 2011
Publication date:
February 9, 2012
Applicant:
TANDEM DIAGNOSTICS, INC.
Inventors:
Arnold Oliphant, Andrew Sparks, John Stuelpnagel, Ken Song