Abstract: Methods for administering apomorphine to a patient for the treatment of sexual dysfunctions while reducing undesirable side effects are disclosed. In the methods, the concentration of apomorphine is attained within the patients' plasma of up to 10 nanograms per milliliter. Advantageously, this concentration may be achieved with less than 15% of patients so treated experiencing emesis. Methods of administration are intranasally, by inhalation to the lungs or by oral ingestion.
Type:
Application
Filed:
March 14, 2001
Publication date:
January 17, 2002
Applicant:
TAP Holdings, Inc.
Inventors:
Pramod K. Gupta, John Daniel Bollinger, Yisheng Chen, Jack Yuqun Zheng, Thomas L. Reiland, Dennis Y. Lee
Abstract: A class of .OMEGA.-substituted-1,4-benzoquinon-2-yl]alkanoic acids are useful in the treatment of chronic obstructive pulmonary disease (COPD). The preferred compound for the method of treatment is 7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid or a pharmaceutically acceptable salt, ester or pro-drug thereof.
Abstract: Peptides possessing LHRH antagonistic activity, and useful for the controlling the release of LHRH in mammals are decapeptide analogues of LHRH having a lactam group at the N-terminus of the formula ##STR1## where n is 1, 2, or 3 and R.sup.1 is selected from the group consisting of hydrogen, benzyl, 4-chlorobenzyl, 2-methylnaphth-1-yl, 1-methylnaphth-2-yl, and quinolin-3-ylmethyl.
Type:
Grant
Filed:
December 8, 1994
Date of Patent:
May 14, 1996
Assignee:
TAP Holdings Inc.
Inventors:
Rolf E. Swenson, Fortuna Haviv, Nicholas A. Mort
Abstract: A class of cyclic peptides are effective inhibitors of LHRH and are useful in the treatment of disease conditions which are mediated by sex hormones including prostate cancer, endometriosis, uterine fibroids, and precocious puberty.
Abstract: Decapaptide and undecapaptides substituted on the N-terminal nitrogen atom by acyl groups which include furo-2-yl, isonicotinyl, nicotinyl, 2-, 3-, and 4-quinolinecarbonyl, shikimyl, dihydroshikimyl, and tetrahydrofur-2-oyl are potent antagonists of LHRH and are useful for suppressing the levels of sex hormones in mammals.
Type:
Grant
Filed:
July 27, 1994
Date of Patent:
March 26, 1996
Assignee:
Tap Holdings Inc.
Inventors:
Fortuna Haviv, Timothy D. Fitzpatrick, Rolf E. Swenson, Charles J. Nichols, Nicholas A. Mort
Abstract: A class of potent LHRH decapeptide antagonists possess N-alkylated aminoacyl residues where the side-chain portion of the residue is a 4-(substimtedamino)phenylalanyl, 4-(substituted-amino)cyclohexylalanyl, or .OMEGA.-(substitutedamino)alkyl group, and additionally the aminoacyl residues at position 5 are N-alkylated on the nitrogen atom of the peptide backbone.
Type:
Grant
Filed:
July 28, 1994
Date of Patent:
February 13, 1996
Assignee:
TAP Holding Inc.
Inventors:
Fortuna Haviv, Jonathan Greer, Rolf E. Swenson, Daryl R. Sauer