Patents Assigned to TargaGenix, Inc.
  • COMBINATION TAXOID NANOEMULSION WITH IMMUNOTHERAPY IN CANCER
    Publication number: 20230082272
    Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate formulated in an oil-in-water nanoemulsion (NE) drug delivery system in combination with an immune-oncology (IO) agent to enhance therapeutic efficacy in refractory cancers, such as PDAC. A method of treating cancer, by administering an effective amount of a pharmaceutical composition including an omega03 PUFA-taxoid conjugate in combination with an IO agent encapsulated in an NE drug delivery system to a subject in need of treatment, and treating cancer.
    Type: Application
    Filed: November 14, 2022
    Publication date: March 16, 2023
    Applicants: TargaGenix, Inc., The Research Foundation for the State University of New York, Northeastern University
    Inventors: James E. EGAN, Mansoor M. AMIJI, Iwao OJIMA
  • Combination taxoid nanoemulsion with immunotherapy in cancer
    Patent number: 11497713
    Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate formulated in an oil-in-water nanoemulsion (NE) drug delivery system in combination with an immune-oncology (IO) agent to enhance therapeutic efficacy in refractory cancers, such as PDAC. A method of treating cancer, by administering an effective amount of a pharmaceutical composition including an omega03 PUFA-taxoid conjugate in combination with an IO agent encapsulated in an NE drug delivery system to a subject in need of treatment, and treating cancer.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: November 15, 2022
    Assignees: TargaGenix, Inc., The Research Foundation for The State University of New York, Northeastern University
    Inventors: James E. Egan, Mansoor Amiji, Iwao Ojima
  • COMBINATION TAXOID NANOEMULSION WITH IMMUNOTHERAPY IN CANCER
    Publication number: 20190183796
    Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate formulated in an oil-in-water nanoemulsion (NE) drug delivery system in combination with an immune-oncology (IO) agent to enhance therapeutic efficacy in refractory cancers, such as PDAC. A method of treating cancer, by administering an effective amount of a pharmaceutical composition including an omega03 PUFA-taxoid conjugate in combination with an IO agent encapsulated in an NE drug delivery system to a subject in need of treatment, and treating cancer.
    Type: Application
    Filed: December 19, 2018
    Publication date: June 20, 2019
    Applicants: TargaGenix, Inc., The Research Foundation for The State University of New York, Northeastern University
    Inventors: James E. Egan, Mansoor Amiji, Iwao Ojima
  • Nanoemulsion compositions of taxoid drugs, and methods for the use thereof to target cancer cells and cancer stem cells
    Patent number: 10206875
    Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water nanoemulsion (NE) drug delivery system. A method of treating cancer by administering an effective amount of a pharmaceutical composition including a PUFA-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system to a subject in need of treatment, and treating cancer. A method of overcoming multidrug resistance by exposing a multidrug resistant cell to an effective amount of a pharmaceutical composition including an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system, and inducing the death of the multidrug resistant cell. A method of eliminating a cancer stem cell. Methods of reducing stemness of a cancer stem cell, retaining drug in the body, and providing a slower release profile.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: February 19, 2019
    Assignees: TargaGenix, Inc., The Research Foundation for the State University New York, Northeastern University
    Inventors: James E. Egan, Iwao Ojima, Mansoor M. Amiji, Galina Ivanovna Botchkina
  • NANOEMULSION COMPOSITIONS OF TAXOID DRUGS, AND METHODS FOR THE USE THEREOF TO TARGET CANCER CELLS AND CANCER STEM CELLS
    Publication number: 20180028442
    Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water nanoemulsion (NE) drug delivery system. A method of treating cancer by administering an effective amount of a pharmaceutical composition including a PUFA-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system to a subject in need of treatment, and treating cancer. A method of overcoming multidrug resistance by exposing a multidrug resistant cell to an effective amount of a pharmaceutical composition including an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system, and inducing the death of the multidrug resistant cell. A method of eliminating a cancer stem cell. Methods of reducing stemness of a cancer stem cell, retaining drug in the body, and providing a slower release profile.
    Type: Application
    Filed: June 7, 2017
    Publication date: February 1, 2018
    Applicants: TargaGenix, Inc., The Research Foundation for the State University New York, Northeastern University
    Inventors: James E. EGAN, Iwao OJIMA, Mansoor M. AMIJI, Galina Ivanovna BOTCHKINA