Abstract: A method for accurately administering a substance to a subject in motion is provided including obtaining one or more scans of the subject. The subject has at least one defined target region thereon for delivery of the substance. A three dimensional position of the subject in motion is calculated based on the obtained one or more scans of the subject. The three dimensional position includes X, Y, and Z coordinates defining the three dimensional position. A timing adjustment is calculated based on the calculated three dimensional position of the subject in motion. A timing of the delivery of the substance to the at least one defined target region is adjusted based on the subject using the calculated timing adjustment. The obtaining, calculating the three dimensional position, calculating the timing adjustment and the adjusting are performed by at least one processor.