Abstract: Compositions and methods for molecular imaging of selectins are disclosed. Specifically, compositions comprising medical imaging contrast-producing agents associated with the extracellular domain of TIM-1 as a targeting ligand for use in molecular imaging of selectins are disclosed. Also, methods of using the extracellular domain of TIM-1 as a ligand for achieving specific targeting to selectins as therapeutic drug delivery vehicles is also disclosed.
Abstract: Methods, compositions and a two-chamber apparatus are provided for use in the separation of a biological substances type from a complex liquid mixture utilizing buoyant microbubble compositions.
Type:
Application
Filed:
January 28, 2015
Publication date:
August 6, 2015
Applicant:
Targeson, Inc.
Inventors:
Joshua L. Rychak, Dan J. Smith, Alice Luong, B. Jack DeFranco
Abstract: The present invention generally relates to microbubble contrast agent compositions which are detectable by optical imaging methods, such as fluorescence, near-infrared or bioluminescence. Uses of the described compositions for imaging and therapeutic applications are contemplated.
Abstract: The invention relates to microbubble contrast agent compositions comprising a gas core encapsulated by a monolayer shell, said shell comprising a first surfactant, a second surfactant having a higher water solubility than said first surfactant, an anchor molecule attached to said shell at the gas-shell interface and an optically-active probe, said probe being detectable by fluorescence, near-infrared, bioluminescence, or other optical imaging methods. Uses of the described compositions for imaging and therapeutic applications are contemplated.