Patents Assigned to Target Discovery, Inc.
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Patent number: 8352193Abstract: Methods and apparatuses for deriving the sequence of an oligomer. In one exemplary method for deriving the sequence of a polypeptide, a predetermined set of mass/charge values for amino acid sequences is stored. An abundance value from mass spectrum data for each mass/charge value in the predetermined set is determined to produce a plurality of abundance values. A first ranking, based on the plurality of abundance values, is calculated for each sequence of a set of amino acid sequences having a first number of amino acids. A second ranking, based on the plurality of abundance values, for each sequence of a set of amino acid sequences having a second number of amino acids is calculated. A cumulative ranking, based on the first ranking and the second ranking, is calculated for each sequence of a set of amino acid sequences having at least the second number of amino acids.Type: GrantFiled: May 30, 2006Date of Patent: January 8, 2013Assignee: Target Discovery, Inc.Inventors: Luke V. Schneider, Michael P. Hall, Robert Petesch
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Patent number: 8003076Abstract: The present invention provides methods and apparatus for purifying metabolites of interest and conducting metabolic analyses. The methods generally involve determining metabolic flux values for a plurality of target analytes by monitoring the relative isotope abundance of a stable isotope in a substrate labeled with the stable isotope and/or one or more target metabolites formed through metabolism of the labeled substrate. Certain methods utilize multiple electrophoretic methods to separate the target analytes from other components within the sample being analyzed. The methods can be used in a variety of applications including screens to identify metabolites that are correlated with certain diseases and diagnostic screens for identifying individuals having, or susceptible to, a disease.Type: GrantFiled: June 25, 2008Date of Patent: August 23, 2011Assignee: Target Discovery, Inc.Inventor: Luke V. Schneider
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Publication number: 20090121124Abstract: A mass spectrometry ionization method in which electrospray droplets or solid sample matrices are exposed to an ion beam thereby increasing the unbalanced charge of the analyte is provided. In another embodiment, a mass spectrometry ionization method in which ionization of the sample is achieved by directing an ion beam at a liquid or solid sample matrix containing analyte thereby ionizing and adding unbalanced charge to the analyte is provided.Type: ApplicationFiled: July 2, 2008Publication date: May 14, 2009Applicant: Target Discovery, Inc.Inventor: Luke V. Schneider
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Publication number: 20090010915Abstract: The present invention provides methods and apparatus for purifying metabolites of interest and conducting metabolic analyses. The methods generally involve determining metabolic flux values for a plurality of target analytes by monitoring the relative isotope abundance of a stable isotope in a substrate labeled with the stable isotope and/or one or more target metabolites formed through metabolism of the labeled substrate. Certain methods utilize multiple electrophoretic methods to separate the target analytes from other components within the sample being analyzed. The methods can be used in a variety of applications including screens to identify metabolites that are correlated with certain diseases and diagnostic screens for identifying individuals having, or susceptible to, a disease.Type: ApplicationFiled: June 25, 2008Publication date: January 8, 2009Applicant: Target Discovery, Inc.Inventor: Luke V. Schneider
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Patent number: 7462823Abstract: A mass spectrometry ionization method in which electrospray droplets or solid sample matrices are exposed to an ion beam thereby increasing the unbalanced charge of the analyte is provided. In another embodiment, a mass spectrometry ionization method in which ionization of the sample is achieved by directing an ion beam at a liquid or solid sample matrix containing analyte thereby ionizing and adding unbalanced charge to the analyte is provided.Type: GrantFiled: May 3, 2006Date of Patent: December 9, 2008Assignee: Target Discovery, Inc.Inventor: Luke V. Schneider
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Patent number: 7435406Abstract: The present invention provides methods and apparatus for purifying metabolites of interest and conducting metabolic analyses. The methods generally involve determining metabolic flux values for a plurality of target analytes by monitoring the relative isotope abundance of a stable isotope in a substrate labeled with the stable isotope and/or one or more target metabolites formed through metabolism of the labeled substrate. Certain methods utilize multiple electrophoretic methods to separate the target analytes from other components within the sample being analyzed. The methods can be used in a variety of applications including screens to identify metabolites that are correlated with certain diseases and diagnostic screens for identifying individuals having, or susceptible to, a disease.Type: GrantFiled: December 20, 2004Date of Patent: October 14, 2008Assignee: Target Discovery, Inc.Inventor: Luke V. Schneider
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Patent number: 7316931Abstract: Mass tagging methods are provided that lead to mass spectrometer detection sensitivities and molecular discriminations that are improved over other methods. In particular the methods are useful for discriminating tagged molecules and fragments of molecules from chemical noise in the mass spectrum. These mass tagging methods are useful for oligomer sequencing, determining the relative abundances of molecules from different samples, and identifying individual molecules or chemical processing steps in combinatorial chemical libraries. The methods provided are useful for the simultaneous analysis of multiple molecules and reaction mixtures by mass spectrometric methods.Type: GrantFiled: August 6, 2004Date of Patent: January 8, 2008Assignee: Target Discovery, Inc.Inventors: Luke V. Schneider, Michael P. Hall, Robert Petesch
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Publication number: 20070154900Abstract: Methods and apparatuses for deriving the sequence of an oligomer. In one exemplary method for deriving the sequence of a polypeptide, a predetermined set of mass/charge values for amino acid sequences is stored. An abundance value from mass spectrum data for each mass/charge value in the predetermined set is determined to produce a plurality of abundance values. A first ranking, based on the plurality of abundance values, is calculated for each sequence of a set of amino acid sequences having a first number of amino acids. A second ranking, based on the plurality of abundance values, for each sequence of a set of amino acid sequences having a second number of amino acids is calculated. A cumulative ranking, based on the first ranking and the second ranking, is calculated for each sequence of a set of amino acid sequences having at least the second number of amino acids.Type: ApplicationFiled: May 30, 2006Publication date: July 5, 2007Applicant: Target Discovery, IncInventors: Luke Schneider, Michael Hall, Robert Petesch
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Patent number: 7211376Abstract: The invention provides methods, compositions, apparatus, and a computer data retrieval system for conducting proteomics.Type: GrantFiled: November 21, 2003Date of Patent: May 1, 2007Assignee: Target Discovery, Inc.Inventors: Luke V. Schneider, Michael P. Hall, Robert Petesch, Jeffrey N. Peterson
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Patent number: 7084396Abstract: A mass spectrometry ionization method in which electrospray droplets or solid sample matrices are exposed to an ion beam thereby increasing the unbalanced charge of the analyte is provided. In another embodiment, a mass spectrometry ionization method in which ionization of the sample is achieved by directing an ion beam at a liquid or solid sample matrix containing analyte thereby ionizing and adding unbalanced charge to the analyte is provided.Type: GrantFiled: October 28, 2003Date of Patent: August 1, 2006Assignee: Target Discovery, Inc.Inventor: Luke V. Schneider
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Publication number: 20060120961Abstract: Novel methods and apparatuses are provided for use in identifying glucose metabolic products and determining metabolic flux by administering D7-glucose to a subject.Type: ApplicationFiled: October 28, 2005Publication date: June 8, 2006Applicant: Target Discovery, Inc.Inventors: Luke Schneider, Michael Hall
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Publication number: 20050153346Abstract: The present invention provides methods and apparatus for purifying metabolites of interest and conducting metabolic analyses. The methods generally involve determining metabolic flux values for a plurality of target analytes by monitoring the relative isotope abundance of a stable isotope in a substrate labeled with the stable isotope and/or one or more target metabolites formed through metabolism of the labeled substrate. Certain methods utilize multiple electrophoretic methods to separate the target analytes from other components within the sample being analyzed. The methods can be used in a variety of applications including screens to identify metabolites that are correlated with certain diseases and diagnostic screens for identifying individuals having, or susceptible to, a disease.Type: ApplicationFiled: December 20, 2004Publication date: July 14, 2005Applicant: Target Discovery, Inc.Inventor: Luke Schneider
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Publication number: 20050089930Abstract: The invention provides methods, compositions, apparatus, and a computer data retrieval system for conducting proteomics.Type: ApplicationFiled: November 21, 2003Publication date: April 28, 2005Applicant: Target Discovery, Inc.Inventors: Luke Schneider, Michael Hall, Robert Petesch, Jeffrey Peterson
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Patent number: 6849396Abstract: The present invention provides methods and apparatus for purifying metabolites of interest and conducting metabolic analyses. The methods generally involve determining metabolic flux values for a plurality of target analytes by monitoring the relative isotope abundance of a stable isotope in a substrate labeled with the stable isotope and/or one or more target metabolites formed through metabolism of the labeled substrate. Certain methods utilize multiple electrophoretic methods to separate the target analytes from other components within the sample being analyzed. The methods can be used in a variety of applications including screens to identify metabolites that are correlated with certain diseases and diagnostic screens for identifying individuals having, or susceptible to, a disease.Type: GrantFiled: October 17, 2003Date of Patent: February 1, 2005Assignee: Target Discovery, Inc.Inventor: Luke V. Schneider
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Publication number: 20050001162Abstract: A mass spectrometry ionization method in which electrospray droplets or solid sample matrices are exposed to an ion beam thereby increasing the unbalanced charge of the analyte is provided. In another embodiment, a mass spectrometry ionization method in which ionization of the sample is achieved by directing an ion beam at a liquid or solid sample matrix containing analyte thereby ionizing and adding unbalanced charge to the analyte is provided.Type: ApplicationFiled: October 28, 2003Publication date: January 6, 2005Applicant: Target Discovery, Inc.Inventor: Luke Schneider
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Publication number: 20040262160Abstract: The present method provides methods and apparatus for separating proteins using a series of electrophoretic methods that utilize controlled fractionation and labeling techniques to resolve mixtures of proteins. The samples for each electrophoretic method other than the initial method, contain only a subset of proteins resolved in the preceding method. The methods can be used in a variety of different applications including, creating proteomic databases, comparative expression studies, diagnostics, structure activity relationships and metabolic engineering investigations.Type: ApplicationFiled: July 26, 2004Publication date: December 30, 2004Applicant: Target Discovery, Inc.Inventors: Luke V. Schneider, Michael P. Hall, Robert Petesch
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Patent number: 6818112Abstract: The present method provides methods and apparatus for separating proteins using a series of electrophoretic methods that utilize controlled fractionation and labeling techniques to resolve mixtures of proteins. The samples for each electrophoretic method other than the initial method, contain only a subset of proteins resolved in the preceding method. The methods can be used in a variety of different applications including, creating proteomic databases, comparative expression studies, diagnostics, structure activity relationships and metabolic engineering investigations.Type: GrantFiled: January 13, 2003Date of Patent: November 16, 2004Assignee: Target Discovery, Inc.Inventors: Luke V. Schneider, Michael P. Hall, Robert Petesch
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Patent number: 6764817Abstract: The present invention provides methods and apparatus for purifying metabolites of interest and conducting metabolic analyses. The methods generally involve determining metabolic flux values for a plurality of target analytes by monitoring the relative isotope abundance of a stable isotope in a substrate labeled with the stable isotope and/or one or more target metabolites formed through metabolism of the labeled substrate. Certain methods utilize multiple electrophoretic methods to separate the target analytes from other components within the sample being analyzed. The methods can be used in a variety of applications including screens to identify metabolites that are correlated with certain diseases and diagnostic screens for identifying individuals having, or susceptible to, a disease.Type: GrantFiled: April 19, 2000Date of Patent: July 20, 2004Assignee: Target Discovery, Inc.Inventor: Luke V. Schneider
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Publication number: 20040133355Abstract: Systems biology models of biochemical systems have proved to be powerful conceptual tools for the analysis of biological data but have historically been arduous to formulate and test. Biological data is also unique in that it exists mostly in the differential display format, unsuitable for use in standard mathematical modeling efforts. The present invention removes the drudgery of model building and data analysis from the shoulders of the individual researchers—who are no longer able assimilate the overwhelming volume of bioinformatic data and synthesize this into a model of the underlying physiology—by providing an artificial intelligence (Al) substitute. In addition to the use of Al methods for building the invention describes the use of difference equations and linear algebra to recast the models into another mathematical domain, allowing the direct use of differential display data formats for model testing and eliminating the need for time-consuming numerical integration.Type: ApplicationFiled: October 1, 2003Publication date: July 8, 2004Applicant: Target Discovery, Inc.Inventor: Luke V. Schneider
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Publication number: 20040091943Abstract: The present invention provides methods and apparatus for purifying metabolites of interest and conducting metabolic analyses. The methods generally involve determining metabolic flux values for a plurality of target analytes by monitoring the relative isotope abundance of a stable isotope in a substrate labeled with the stable isotope and/or one or more target metabolites formed through metabolism of the labeled substrate. Certain methods utilize multiple electrophoretic methods to separate the target analytes from other components within the sample being analyzed. The methods can be used in a variety of applications including screens to identify metabolites that are correlated with certain diseases and diagnostic screens for identifying individuals having, or susceptible to, a disease.Type: ApplicationFiled: October 17, 2003Publication date: May 13, 2004Applicant: Target Discovery, Inc.Inventor: Luke V. Schneider