Abstract: The present invention is related to compositions and methods for treating platelet-related diseases.

Abstract: A preoperative tumor marking may be used to assist physicians in the removal of tumor tissue by clearly defining the margins of the tumor. An imaging technique, such as mammography, may be employed to visualize the tumor. The visualized tumor may be marked with a polymer, either directly or indirectly. The polymer may be liquid at room temperature and harden at body temperature, making the tumor palpable, but not changing the tumor's cellular and physical state. The polymer may also include a coloring agent that may aid in visualizing the lesion. This will assist a surgeon during excision by allowing him/her to both feel and see the tumor and remove enough of the tissue surrounding the tumor to greatly reduce the need for a second surgical procedure due to a failure to remove all tumor tissue during an initial surgery.

Abstract: Dipicolylamine compounds of Formula (I) set forth herein. Also disclosed are pharmaceutical compositions containing metal ions and these compounds. Further disclosed is a method for treating a condition associated with cells containing inside-out phosphatidylserine, with these compounds.

Abstract: Embodiments provide dual modality probes for imaging phosphatidylserine (PS) exposure and other anionic membrane surfaces. In various embodiments, the probes were constructed by utilizing a) the high selectivity of synthetic zinc (II) dipicolylamine coordination complexes (Zn-DPA) for targeting externalized PS which over-expresses in apoptotic and necrotic cells, b) a near-infrared (NIR) dye for optical imaging, and c) a widely used clinically approved radionuclide for PET (or SPECT) imaging. A variety of linking elements were incorporated into the probes between the Zn-DPA and radionuclide motif to modulate the pharmacokinetics. The in vitro and in vivo data of radiolabeled dipicolylamine probes demonstrated their utilities for imaging PS exposure with multiple imaging modalities.

Abstract: Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to novel near-infrared dyes that are photostable and resistant to quenching. The dyes belong to a novel family of squaraine rotaxanes, and they are particularly well-suited for use in biological applications. Also disclosed are methods of synthesizing the dyes and methods of using the dyes.

Abstract: A preoperative tumor marking may be used to assist physicians in the removal of tumor tissue by clearly defining the margins of the tumor. An imaging technique, such as mammography, may be employed to visualize the tumor. The visualized tumor may be marked with a polymer, either directly or indirectly. The polymer may be liquid at room temperature and harden at body temperature, making the tumor palpable, but not changing the tumor's cellular and physical state. The polymer may also include a coloring agent that may aid in visualizing the lesion. This will assist a surgeon during excision by allowing him/her to both feel and see the tumor and remove enough of the tissue surrounding the tumor to greatly reduce the need for a second surgical procedure due to a failure to remove all tumor tissue during an initial surgery.

Abstract: Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to novel near-infrared dyes that are photostable and resistant to quenching. The dyes belong to a novel family of squaraine rotaxanes, and they are particularly well-suited for use in biological applications. Also disclosed are methods of synthesizing the dyes and methods of using the dyes.

Abstract: A videoconferencing network for digital computer workstations that operate on a local area network (LAN) to exchange data. The network includes a signalling local area network (A-LAN), connected to a first port of a plurality of workstations, for transmitting and receiving data signals between selected ones of the workstations and a broadband local area network (B-LAN) connected to a second port of the plurality of workstations, for transmitting and receiving television signals between selected ones of these workstations. Each television signal is transmitted at a selected frequency channel so that no two transmissions interfere. A software program, stored in and operable on the computer of each workstation, generates and receives data messages, transmitted via the A-LAN, to and from the computer of another workstation, respectively.

Abstract: A videoconferencing network for digital computer workstations that operate on a local area network (LAN) to exchange data. The network includes a signalling local area network (A-LAN), connected to a first port of a plurality of workstations, for transmitting and receiving data signals between selected ones of the workstations and a broadband local area network (B-LAN) connected to a second port of the plurality of workstations, for transmitting and receiving television signals between selected ones of these workstations. Each television signal is transmitted at a selected frequency channel so that no two transmissions interfere. A software program, stored in and operable on the computer of each workstation, generates and receives data messages, transmitted via the A-LAN, to and from the computer of another workstation, respectively.

Abstract: In the fabrication of an ink jet nozzle structure for ink jet printing, photoform glass is initially exposed in the general configuration of the ink chambers and nozzles desired to be formed in the glass. Thin transverse lines are left unexposed across the desired transition point between the ink chamber and the nozzle, and across a transition between ink inlet and the chamber. The ink chamber is desired to be of greater depth than either the inlet area or the nozzle, so two-step acid etching is used. The nozzle and the inlet are masked, as by taping, during a portion of the acid etching and unmasked during another portion, so that the chamber (which is never masked) is etched deeper than the inlet and nozzle areas.