Patents Assigned to Target Therapeutics
  • Patent number: 10434170
    Abstract: An immune-regulatory vaccine comprising—a directed adjuvant comprising at least an anti-CD32 moiety linked to a TLR9 ligand and a first peptidic alpha-helix, and—an immunogen with at least one epitope and a second peptidic alpha-helix coiled to the first alpha-helix, a kit for preparing the vaccine, and a sensibilizing vaccine comprising at least an anti-CD32 moiety linked to a TLR9 ligand and a peptidic alpha-helix in a pharmaceutical formulation.
    Type: Grant
    Filed: July 2, 2013
    Date of Patent: October 8, 2019
    Assignee: S-TARGET THERAPEUTICS GMBH
    Inventor: Geert Mudde
  • Patent number: 10233219
    Abstract: The present application provides methods for preparing soluble lipidated ligand agents comprising a ligand entity and a lipid entity, and in some embodiments, provides relevant parameters of each of these components, thereby enabling appropriate selection of components to assemble active agents for any given target of interest.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: March 19, 2019
    Assignees: Tufts Medical Center, Trustees of Tufts College, On Target Therapeutics LLC
    Inventors: Charles Cohen, Krishna Kumar, Jamie Raudensky Doyle, Alan S. Kopin
  • Patent number: 10189905
    Abstract: A molecule or molecule complex capable of binding to TLR9 and to CD32 comprising at least one epitope of at least one antigen, and its use a medicament for the treatment of allergies.
    Type: Grant
    Filed: May 29, 2017
    Date of Patent: January 29, 2019
    Assignee: S-TARGET THERAPEUTICS GMBH
    Inventors: Geert Mudde, Gottfried Himmler
  • Patent number: 9636415
    Abstract: A molecule or molecule complex capable of binding to TLR9 and to CD32 comprising at least one epitope of at least one antigen, and its use a medicament for the treatment of allergies.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: May 2, 2017
    Assignee: S-TARGET THERAPEUTICS GMBH
    Inventors: Geert Mudde, Gottfried Himmler
  • Publication number: 20150196636
    Abstract: An immune-regulatory vaccine comprising—a directed adjuvant comprising at least an anti-CD32 moiety linked to a TLR9 ligand and a first peptidic alpha-helix, and—an immunogen with at least one epitope and a second peptidic alpha-helix coiled to the first alpha-helix, a kit for preparing the vaccine, and a sensibilizing vaccine comprising at least an anti-CD32 moiety linked to a TLR9 ligand and a peptidic alpha-helix in a pharmaceutical formulation.
    Type: Application
    Filed: July 2, 2013
    Publication date: July 16, 2015
    Applicant: S-TARGET THERAPEUTICS GMBH
    Inventor: Geert Mudde
  • Patent number: 8317772
    Abstract: A catheter comprising an elongate tubular member having a proximal end, a distal end, and a passageway defining a lumen extending between the proximal and distal ends. The elongate tubular member comprises a relatively stiff proximal section and a relatively flexible distal section. The proximal section includes an inner tubular liner, a first stiffener comprising a metal alloy, and a second stiffener comprising a non-metal alloy. The first and second stiffeners are coaxially wound exterior to the proximal inner liner. The distal section includes a distal inner tubular liner and the second stiffener coaxially wound exterior to the distal inner liner. The first stiffener terminates before reaching the distal section.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: November 27, 2012
    Assignee: Target Therapeutics, Inc.
    Inventors: Lex P. Jansen, Thomas Yung-Hui Chien, Perry Alvin Fukui, Jeffrey A. Sarge, Lawrence Charles Alpert
  • Patent number: 8181324
    Abstract: A catheter section comprising an elongate tubular member having a proximal end, a distal end, and a passageway defining a lumen extending between the proximal and distal ends. The elongate tubular member includes a knit tubular member and an inner tubular liner in coaxial relationship with the knit tubular member. The catheter section is for use as a distal section in a catheter having a relatively stiff proximal section.
    Type: Grant
    Filed: October 18, 2010
    Date of Patent: May 22, 2012
    Assignee: Target Therapeutics, Inc.
    Inventors: Jill M. McFadden, Earl Bardsley, Robert Garabedian
  • Publication number: 20110172643
    Abstract: A catheter comprising an elongate tubular member having a proximal end, a distal end, and a passageway defining a lumen extending between the proximal and distal ends. The elongate tubular member comprises a relatively stiff proximal section and a relatively flexible distal section. The proximal section includes an inner tubular liner, a first stiffener comprising a metal alloy, and a second stiffener comprising a non-metal alloy. The first and second stiffeners are coaxially wound exterior to the proximal inner liner. The distal section includes a distal inner tubular liner and the second stiffener coaxially wound exterior to the distal inner liner. The first stiffener terminates before reaching the distal section.
    Type: Application
    Filed: March 10, 2011
    Publication date: July 14, 2011
    Applicant: TARGET THERAPEUTICS, INC.
    Inventors: Lex P. Jansen, Thomas Yung-Hui Chien, Perry Alvin Fukui, Jeffrey A. Sarge, Lawrence Charles Alpert
  • Publication number: 20110144625
    Abstract: This is a composite guidewire for use with a catheter for accessing a targeted site in a lumen system of a patient's body. The guidewire core or guidewire section may be of a stainless steel or a high elasticity metal alloy, preferably a Ni—Ti alloy, also preferably having specified physical parameters. The composite guidewire assembly is especially useful for accessing peripheral or soft tissue targets. The invention includes multi-section guidewire assemblies having super-elastic alloy or stainless steel ribbon braided reinforcements along a least a portion of the core. A variation of the inventive guidewire includes a braid and a tie layer (and one or more lubricious polymers on the tie layer exterior) to enhance the guidewire's suitability for use within catheters and within the interior of vascular lumen.
    Type: Application
    Filed: February 7, 2011
    Publication date: June 16, 2011
    Applicant: TARGET THERAPEUTICS, INC.
    Inventors: Gregory E. Mirigian, Harold F. Carrison, Laurent Schaller, Erik T. Engelson
  • Publication number: 20110082493
    Abstract: This is a surgical device usually delivered through an intravascular catheter. It may be used in several ways. It may, for instance, be used to open a clear passageway adjacent thrombus to allow both blood and medication to bypass the clot. It may be used to pierce and to remove thrombus. These thrombus are often found in tortuous vasculature. The device includes several sections. The device has a core element, typically a core wire. Placed around the distal end of the core element is a collapsible but preferably self expanding proximal cage assembly and a distal filter, preferably a self-expanding cage assembly or other filter component. The various portions of those components are preferably radio-opaque. The proximal end of the proximal cage is typically is affixed to an actuator in such a way as to allow expansion of the cage after deployment.
    Type: Application
    Filed: December 13, 2010
    Publication date: April 7, 2011
    Applicant: TARGET THERAPEUTICS, INC.
    Inventors: Gene Samson, Harold F. Carrison
  • Patent number: 7909812
    Abstract: A catheter comprising an elongate tubular member having a proximal end, a distal end, and a passageway defining a lumen extending between the proximal and distal ends. The elongate tubular member comprises a relatively stiff proximal section and a relatively flexible distal section. The proximal section includes an inner tubular liner, a first stiffener comprising a metal alloy, and a second stiffener comprising a non-metal alloy. The first and second stiffeners are coaxially wound exterior to the proximal inner liner. The distal section includes a distal inner tubular liner and the second stiffener coaxially wound exterior to the distal inner liner. The first stiffener terminates before reaching the distal section.
    Type: Grant
    Filed: September 6, 2006
    Date of Patent: March 22, 2011
    Assignee: Target Therapeutics, Inc.
    Inventors: Lex P. Jansen, Thomas Yung-Hui Chien, Perry Alvin Fukui, Jeffrey A. Sarge, Lawrence Charles Alpert
  • Patent number: 7883474
    Abstract: This is a composite guidewire for use with a catheter for accessing a targeted site in a lumen system of a patient's body. The guidewire core or guidewire section may be of a stainless steel or a high elasticity metal alloy, preferably a Ni—Ti alloy, also preferably having specified physical parameters. The composite guidewire assembly is especially useful for accessing peripheral or soft tissue targets. The invention includes multi-section guidewire assemblies having super-elastic alloy or stainless steel ribbon braided reinforcements along a least a portion of the core. A variation of the inventive guidewire includes a braid and a tie layer (and one or more lubricious polymers on the tie layer exterior) to enhance the guidewire's suitability for use within catheters and within the interior of vascular lumen.
    Type: Grant
    Filed: April 30, 1996
    Date of Patent: February 8, 2011
    Assignee: Target Therapeutics, Inc.
    Inventors: Gregory E. Mirigian, Harold E. Carrison, Laurent Schaller, Erik T. Engelson
  • Publication number: 20110024025
    Abstract: A catheter section comprising an elongate tubular member having a proximal end, a distal end, and a passageway defining a lumen extending between the proximal and distal ends. The elongate tubular member includes a knit tubular member and an inner tubular liner in coaxial relationship with the knit tubular member. The catheter section is for use as a distal section in a catheter having a relatively stiff proximal section.
    Type: Application
    Filed: October 18, 2010
    Publication date: February 3, 2011
    Applicant: TARGET THERAPEUTICS, INC.
    Inventors: Jill M. McFadden, Earl Bardsley, Robert Garabedian
  • Patent number: 7875050
    Abstract: An embolism treatment device includes an elongated core wire having a coil tip coupled to the distal end of the core wire and a cage assembly substantially coaxial to the core wire, having a first deployment shape and a second expanded shape. The core wire is freely moveable axially through the cage assembly. The device additionally includes an inner coil surrounding the core wire within the cage assembly and an actuator element, having a first position and a second position, located proximally to the cage assembly, wherein when the actuator element is in the first position, the cage assembly is in the first deployment shape and when the actuator element is in the second position, the cage assembly is in the second expanded shape.
    Type: Grant
    Filed: February 22, 2002
    Date of Patent: January 25, 2011
    Assignee: Target Therapeutics, Inc.
    Inventors: Gene Samson, Harold F Carrison
  • Patent number: 7815626
    Abstract: A catheter section comprising an elongate tubular member having a proximal end, a distal end, and a passageway defining a lumen extending between the proximal and distal ends. The elongate tubular member includes a knit tubular member and an inner tubular liner in coaxial relationship with the knit tubular member. The catheter section is for use as a distal section in a catheter having a relatively stiff proximal section.
    Type: Grant
    Filed: June 12, 1998
    Date of Patent: October 19, 2010
    Assignee: Target Therapeutics, Inc.
    Inventors: Jill M. McFadden, Earl Bardsley, Robert Garabedian
  • Patent number: 7104979
    Abstract: A catheter comprising an elongate tubular member having a proximal end, a distal end, and a passageway defining a lumen extending between the proximal and distal ends. The elongate tubular member comprises a relatively stiff proximal section and a relatively flexible distal section. The proximal section includes an inner tubular liner, a first stiffener comprising a metal alloy, and a second stiffener comprising a non-metal alloy. The first and second stiffeners are coaxially wound exterior to the proximal inner liner. The distal section includes a distal inner tubular liner and the second stiffener coaxially wound exterior to the distal inner liner. The first stiffener terminates before reaching the distal section.
    Type: Grant
    Filed: February 19, 2002
    Date of Patent: September 12, 2006
    Assignee: Target Therapeutics, Inc.
    Inventors: Lex P. Jansen, Thomas Yung-Hui Chien, Perry Alvin Fukui, Jeffrey A. Sarge, Lawrence Charles Alpert
  • Patent number: 6984240
    Abstract: A vasoocclusive helical coil having a proximal end that carries a coupling member for attaching the coil to the distal end of a wire and a proximal winding that has a smaller diameter than adjacent windings whereby the proximal end of the coil is positioned radially inwardly of the main body of the coil.
    Type: Grant
    Filed: October 25, 1996
    Date of Patent: January 10, 2006
    Assignee: Target Therapeutics, Inc.
    Inventors: Christopher G. M. Ken, Abhijit Acharya
  • Publication number: 20050033350
    Abstract: A vasoocclusive helical coil having a proximal end that carries a coupling member for attaching the coil to the distal end of a wire and a proximal winding that has a smaller diameter than adjacent windings whereby the proximal end of the coil is positioned radially inwardly of the main body of the coil.
    Type: Application
    Filed: August 31, 2004
    Publication date: February 10, 2005
    Applicant: Target Therapeutics, Inc.
    Inventors: Christopher Ken, Abhijit Acharya
  • Patent number: 6824553
    Abstract: This is a catheter assembly and a section of that catheter assembly. That catheter assembly may be used in accessing a tissue target within the body, typically a target which is accessible through the vascular system. Central to the invention is the use of a braided metallic reinforcing member, typically of super-elastic alloy ribbon, situated within the catheter body in such a way to create a catheter having an exceptionally thin wall, controlled stiffness, high resistance to kinking, and complete recovery in vivo from kinking situations. The braid may have a single pitch or may vary in pitch along the axis of the catheter or catheter section. The braided ribbon reinforcing member typically is placed between a flexible outer tubing member and an inner tubing member to produce a catheter section which is very flexible but highly kink resistant.
    Type: Grant
    Filed: August 25, 2000
    Date of Patent: November 30, 2004
    Assignee: Target Therapeutics, Inc.
    Inventors: Gene Samson, Uriel Hiram Chee, Kim Nguyen, Edward J. Snyder, Erik T. Engelson
  • Patent number: 6706025
    Abstract: This invention is in the general field of surgical instruments. It relates specifically to catheters which may be used in cardiovascular and endovascular procedures to deliver diagnostic, therapeutic, or vaso-occlusive agents to a target site within a human or animal body which is accessible by a system of natural passageways within that body. The catheters are coated in such a way that they are exceptionally slippery and the coating is very durable. The invention also relates to methods of coating the catheters and to methods of applying lubricious coatings.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: March 16, 2004
    Assignee: Target Therapeutics, Inc.
    Inventors: Erik T. Engelson, Robert Hergenrother, Joseph Eder