Patents Assigned to Target Therapeutics
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Patent number: 11254720Abstract: The present application provides methods for preparing soluble lipidated ligand agents comprising a ligand entity and a lipid entity, and in some embodiments, provides relevant parameters of each of these components, thereby enabling appropriate selection of components to assemble active agents for any given target of interest.Type: GrantFiled: January 11, 2019Date of Patent: February 22, 2022Assignees: On Target Therapeutics LLC, Trustees of Tufts College, Tufts Medical CenterInventors: Charles Cohen, Krishna Kumar, Jamie Raudensky Doyle, Alan S. Kopin
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Patent number: 11197906Abstract: The present disclosure relates to, among other things, compositions and methods for treating an inflammatory condition including, but not limited to, ocular inflammation, dry eye disease, and ocular neuropathic pain. One aspect of the present disclosure relates to a composition comprising (a) chemerin or a fragment or analog thereof and (b) a lipid entity linked to the chemerin or fragment or analog thereof.Type: GrantFiled: January 23, 2017Date of Patent: December 14, 2021Assignees: On Target Therapeutics LLC, Trustees of Tufts College, Tufts Medical CenterInventors: Charles Cohen, Krishna Kumar, Alan S. Kopin, Benjamin N. Harwood, Venkata S. Raman, Pedram Hamrah
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Patent number: 10434170Abstract: An immune-regulatory vaccine comprising—a directed adjuvant comprising at least an anti-CD32 moiety linked to a TLR9 ligand and a first peptidic alpha-helix, and—an immunogen with at least one epitope and a second peptidic alpha-helix coiled to the first alpha-helix, a kit for preparing the vaccine, and a sensibilizing vaccine comprising at least an anti-CD32 moiety linked to a TLR9 ligand and a peptidic alpha-helix in a pharmaceutical formulation.Type: GrantFiled: July 2, 2013Date of Patent: October 8, 2019Assignee: S-TARGET THERAPEUTICS GMBHInventor: Geert Mudde
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Patent number: 10233219Abstract: The present application provides methods for preparing soluble lipidated ligand agents comprising a ligand entity and a lipid entity, and in some embodiments, provides relevant parameters of each of these components, thereby enabling appropriate selection of components to assemble active agents for any given target of interest.Type: GrantFiled: March 13, 2014Date of Patent: March 19, 2019Assignees: Tufts Medical Center, Trustees of Tufts College, On Target Therapeutics LLCInventors: Charles Cohen, Krishna Kumar, Jamie Raudensky Doyle, Alan S. Kopin
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Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies
Patent number: 10189905Abstract: A molecule or molecule complex capable of binding to TLR9 and to CD32 comprising at least one epitope of at least one antigen, and its use a medicament for the treatment of allergies.Type: GrantFiled: May 29, 2017Date of Patent: January 29, 2019Assignee: S-TARGET THERAPEUTICS GMBHInventors: Geert Mudde, Gottfried Himmler -
Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies
Patent number: 9636415Abstract: A molecule or molecule complex capable of binding to TLR9 and to CD32 comprising at least one epitope of at least one antigen, and its use a medicament for the treatment of allergies.Type: GrantFiled: March 8, 2013Date of Patent: May 2, 2017Assignee: S-TARGET THERAPEUTICS GMBHInventors: Geert Mudde, Gottfried Himmler -
Publication number: 20150196636Abstract: An immune-regulatory vaccine comprising—a directed adjuvant comprising at least an anti-CD32 moiety linked to a TLR9 ligand and a first peptidic alpha-helix, and—an immunogen with at least one epitope and a second peptidic alpha-helix coiled to the first alpha-helix, a kit for preparing the vaccine, and a sensibilizing vaccine comprising at least an anti-CD32 moiety linked to a TLR9 ligand and a peptidic alpha-helix in a pharmaceutical formulation.Type: ApplicationFiled: July 2, 2013Publication date: July 16, 2015Applicant: S-TARGET THERAPEUTICS GMBHInventor: Geert Mudde
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Patent number: 8317772Abstract: A catheter comprising an elongate tubular member having a proximal end, a distal end, and a passageway defining a lumen extending between the proximal and distal ends. The elongate tubular member comprises a relatively stiff proximal section and a relatively flexible distal section. The proximal section includes an inner tubular liner, a first stiffener comprising a metal alloy, and a second stiffener comprising a non-metal alloy. The first and second stiffeners are coaxially wound exterior to the proximal inner liner. The distal section includes a distal inner tubular liner and the second stiffener coaxially wound exterior to the distal inner liner. The first stiffener terminates before reaching the distal section.Type: GrantFiled: March 10, 2011Date of Patent: November 27, 2012Assignee: Target Therapeutics, Inc.Inventors: Lex P. Jansen, Thomas Yung-Hui Chien, Perry Alvin Fukui, Jeffrey A. Sarge, Lawrence Charles Alpert
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Patent number: 8181324Abstract: A catheter section comprising an elongate tubular member having a proximal end, a distal end, and a passageway defining a lumen extending between the proximal and distal ends. The elongate tubular member includes a knit tubular member and an inner tubular liner in coaxial relationship with the knit tubular member. The catheter section is for use as a distal section in a catheter having a relatively stiff proximal section.Type: GrantFiled: October 18, 2010Date of Patent: May 22, 2012Assignee: Target Therapeutics, Inc.Inventors: Jill M. McFadden, Earl Bardsley, Robert Garabedian
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Publication number: 20110172643Abstract: A catheter comprising an elongate tubular member having a proximal end, a distal end, and a passageway defining a lumen extending between the proximal and distal ends. The elongate tubular member comprises a relatively stiff proximal section and a relatively flexible distal section. The proximal section includes an inner tubular liner, a first stiffener comprising a metal alloy, and a second stiffener comprising a non-metal alloy. The first and second stiffeners are coaxially wound exterior to the proximal inner liner. The distal section includes a distal inner tubular liner and the second stiffener coaxially wound exterior to the distal inner liner. The first stiffener terminates before reaching the distal section.Type: ApplicationFiled: March 10, 2011Publication date: July 14, 2011Applicant: TARGET THERAPEUTICS, INC.Inventors: Lex P. Jansen, Thomas Yung-Hui Chien, Perry Alvin Fukui, Jeffrey A. Sarge, Lawrence Charles Alpert
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Publication number: 20110144625Abstract: This is a composite guidewire for use with a catheter for accessing a targeted site in a lumen system of a patient's body. The guidewire core or guidewire section may be of a stainless steel or a high elasticity metal alloy, preferably a Ni—Ti alloy, also preferably having specified physical parameters. The composite guidewire assembly is especially useful for accessing peripheral or soft tissue targets. The invention includes multi-section guidewire assemblies having super-elastic alloy or stainless steel ribbon braided reinforcements along a least a portion of the core. A variation of the inventive guidewire includes a braid and a tie layer (and one or more lubricious polymers on the tie layer exterior) to enhance the guidewire's suitability for use within catheters and within the interior of vascular lumen.Type: ApplicationFiled: February 7, 2011Publication date: June 16, 2011Applicant: TARGET THERAPEUTICS, INC.Inventors: Gregory E. Mirigian, Harold F. Carrison, Laurent Schaller, Erik T. Engelson
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Publication number: 20110082493Abstract: This is a surgical device usually delivered through an intravascular catheter. It may be used in several ways. It may, for instance, be used to open a clear passageway adjacent thrombus to allow both blood and medication to bypass the clot. It may be used to pierce and to remove thrombus. These thrombus are often found in tortuous vasculature. The device includes several sections. The device has a core element, typically a core wire. Placed around the distal end of the core element is a collapsible but preferably self expanding proximal cage assembly and a distal filter, preferably a self-expanding cage assembly or other filter component. The various portions of those components are preferably radio-opaque. The proximal end of the proximal cage is typically is affixed to an actuator in such a way as to allow expansion of the cage after deployment.Type: ApplicationFiled: December 13, 2010Publication date: April 7, 2011Applicant: TARGET THERAPEUTICS, INC.Inventors: Gene Samson, Harold F. Carrison
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Patent number: 7909812Abstract: A catheter comprising an elongate tubular member having a proximal end, a distal end, and a passageway defining a lumen extending between the proximal and distal ends. The elongate tubular member comprises a relatively stiff proximal section and a relatively flexible distal section. The proximal section includes an inner tubular liner, a first stiffener comprising a metal alloy, and a second stiffener comprising a non-metal alloy. The first and second stiffeners are coaxially wound exterior to the proximal inner liner. The distal section includes a distal inner tubular liner and the second stiffener coaxially wound exterior to the distal inner liner. The first stiffener terminates before reaching the distal section.Type: GrantFiled: September 6, 2006Date of Patent: March 22, 2011Assignee: Target Therapeutics, Inc.Inventors: Lex P. Jansen, Thomas Yung-Hui Chien, Perry Alvin Fukui, Jeffrey A. Sarge, Lawrence Charles Alpert
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Patent number: 7883474Abstract: This is a composite guidewire for use with a catheter for accessing a targeted site in a lumen system of a patient's body. The guidewire core or guidewire section may be of a stainless steel or a high elasticity metal alloy, preferably a Ni—Ti alloy, also preferably having specified physical parameters. The composite guidewire assembly is especially useful for accessing peripheral or soft tissue targets. The invention includes multi-section guidewire assemblies having super-elastic alloy or stainless steel ribbon braided reinforcements along a least a portion of the core. A variation of the inventive guidewire includes a braid and a tie layer (and one or more lubricious polymers on the tie layer exterior) to enhance the guidewire's suitability for use within catheters and within the interior of vascular lumen.Type: GrantFiled: April 30, 1996Date of Patent: February 8, 2011Assignee: Target Therapeutics, Inc.Inventors: Gregory E. Mirigian, Harold E. Carrison, Laurent Schaller, Erik T. Engelson
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Publication number: 20110024025Abstract: A catheter section comprising an elongate tubular member having a proximal end, a distal end, and a passageway defining a lumen extending between the proximal and distal ends. The elongate tubular member includes a knit tubular member and an inner tubular liner in coaxial relationship with the knit tubular member. The catheter section is for use as a distal section in a catheter having a relatively stiff proximal section.Type: ApplicationFiled: October 18, 2010Publication date: February 3, 2011Applicant: TARGET THERAPEUTICS, INC.Inventors: Jill M. McFadden, Earl Bardsley, Robert Garabedian
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Patent number: 7875050Abstract: An embolism treatment device includes an elongated core wire having a coil tip coupled to the distal end of the core wire and a cage assembly substantially coaxial to the core wire, having a first deployment shape and a second expanded shape. The core wire is freely moveable axially through the cage assembly. The device additionally includes an inner coil surrounding the core wire within the cage assembly and an actuator element, having a first position and a second position, located proximally to the cage assembly, wherein when the actuator element is in the first position, the cage assembly is in the first deployment shape and when the actuator element is in the second position, the cage assembly is in the second expanded shape.Type: GrantFiled: February 22, 2002Date of Patent: January 25, 2011Assignee: Target Therapeutics, Inc.Inventors: Gene Samson, Harold F Carrison
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Patent number: 7815626Abstract: A catheter section comprising an elongate tubular member having a proximal end, a distal end, and a passageway defining a lumen extending between the proximal and distal ends. The elongate tubular member includes a knit tubular member and an inner tubular liner in coaxial relationship with the knit tubular member. The catheter section is for use as a distal section in a catheter having a relatively stiff proximal section.Type: GrantFiled: June 12, 1998Date of Patent: October 19, 2010Assignee: Target Therapeutics, Inc.Inventors: Jill M. McFadden, Earl Bardsley, Robert Garabedian
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Patent number: 7104979Abstract: A catheter comprising an elongate tubular member having a proximal end, a distal end, and a passageway defining a lumen extending between the proximal and distal ends. The elongate tubular member comprises a relatively stiff proximal section and a relatively flexible distal section. The proximal section includes an inner tubular liner, a first stiffener comprising a metal alloy, and a second stiffener comprising a non-metal alloy. The first and second stiffeners are coaxially wound exterior to the proximal inner liner. The distal section includes a distal inner tubular liner and the second stiffener coaxially wound exterior to the distal inner liner. The first stiffener terminates before reaching the distal section.Type: GrantFiled: February 19, 2002Date of Patent: September 12, 2006Assignee: Target Therapeutics, Inc.Inventors: Lex P. Jansen, Thomas Yung-Hui Chien, Perry Alvin Fukui, Jeffrey A. Sarge, Lawrence Charles Alpert
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Patent number: 6984240Abstract: A vasoocclusive helical coil having a proximal end that carries a coupling member for attaching the coil to the distal end of a wire and a proximal winding that has a smaller diameter than adjacent windings whereby the proximal end of the coil is positioned radially inwardly of the main body of the coil.Type: GrantFiled: October 25, 1996Date of Patent: January 10, 2006Assignee: Target Therapeutics, Inc.Inventors: Christopher G. M. Ken, Abhijit Acharya
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Publication number: 20050033350Abstract: A vasoocclusive helical coil having a proximal end that carries a coupling member for attaching the coil to the distal end of a wire and a proximal winding that has a smaller diameter than adjacent windings whereby the proximal end of the coil is positioned radially inwardly of the main body of the coil.Type: ApplicationFiled: August 31, 2004Publication date: February 10, 2005Applicant: Target Therapeutics, Inc.Inventors: Christopher Ken, Abhijit Acharya