Patents Assigned to Tasly Pharmaceutical Group Co., Ltd.
  • Patent number: 12090138
    Abstract: A pharmaceutical composition is prepared from the following raw materials (in parts by weight): silybin (8.75-60), phospholipid (15-65), a Pu'er tea extract (25-200), and vitamin E (6.25-40). The composition has the effect of treating non-alcoholic fatty liver diseases.
    Type: Grant
    Filed: January 28, 2022
    Date of Patent: September 17, 2024
    Assignee: TASLY PHARMACEUTICAL GROUP CO., LTD.
    Inventors: He Sun, Xijun Yan, Naifeng Wu, Kaijing Yan, Yonghong Zhu, Shunnan Zhang, Xiaolin Bai, Xiaohui Ma, Yi He, Ting Li, Lei Li
  • Patent number: 11491173
    Abstract: Disclosed are a pharmaceutical composition and an application thereof. The pharmaceutical composition of the present invention comprises the following components in parts by weight: 2-20 parts of phenolic acids, 0.5-5 parts of flavonoids, 0.005-0.5 part of tanshinones, 5-20 parts of saponins, and 10-18 parts of volatile oils. The pharmaceutical composition has the functions of protecting against myocardial damage and treating heart failure.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: November 8, 2022
    Assignee: TASLY PHARMACEUTICAL GROUP CO., LTD.
    Inventors: Shuiping Zhou, He Sun, Yiqian Zhang, Xiaohui Ma, Jiawen Shi, Yi He, Xinxin Li, Jing Wang, Xiaoqing Li, Lijun Fan, Jingjing Zhang
  • Publication number: 20220151984
    Abstract: A pharmaceutical composition is prepared from the following raw materials (in parts by weight): silybin (8.75-60), phospholipid (15-65), a Pu'er tea extract (25-200), and vitamin E (6.25-40). The composition has the effect of treating non-alcoholic fatty liver diseases.
    Type: Application
    Filed: January 28, 2022
    Publication date: May 19, 2022
    Applicant: TASLY PHARMACEUTICAL GROUP CO., LTD.
    Inventors: He SUN, Xijun YAN, Naifeng WU, Kaijing YAN, Yonghong ZHU, Shunnan ZHANG, Xiaolin BAI, Xiaohui MA, Yi HE, Ting LI, Lei LI
  • Patent number: 11318112
    Abstract: A pharmaceutical composition is prepared from the following raw materials (in parts by weight): silybin (8.75-60), phospholipid (15-65), a Pu'er tea extract (25-200), and vitamin E (6.25-40). The composition has the effect of treating non-alcoholic fatty liver diseases.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: May 3, 2022
    Assignee: TASLY PHARMACEUTICAL GROUP CO., LTD.
    Inventors: He Sun, Xijun Yan, Naifeng Wu, Kaijing Yan, Yonghong Zhu, Shunnan Zhang, Xiaolin Bai, Xiaohui Ma, Yi He, Ting Li, Lei Li
  • Patent number: 11013694
    Abstract: The present invention relates to a preparation method for a traditional Chinese medicine drop pill and a traditional Chinese medicine micro drop pill prepared by using the method, and in particular, the present invention relates to a micro drop pill preparation method with high drug-loading capacity, simple preparation process and high production rate and a micro drop pill prepared by using the method. Specially, The drop pill preparation method used comprises the following steps: (1) material melting step: heat melting a medicine and a drop pill matrix to obtain a molten medicine liquid; (2) dropping step: delivering the molten medicine liquid to a dripper, and acquiring medicine drops of the molten medicine liquid by means of vibration dropping; and, (3) condensation step: cooling the medicine drops with a cooling gas to obtain micro drop pills.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: May 25, 2021
    Assignee: TASLY PHARMACEUTICAL GROUP CO., LTD.
    Inventors: Xijun Yan, Naifeng Wu, Kaijing Yan, Xiaobing Sun, Shunnan Zhang, Zhengliang Ye, Hai'ou Dong, Hongbo Zhang, Wensheng Zhang, Lihong Zhou, Chenming Li, Cong Chen, Xiaofeng Liu, Shiqing Wang, Changsheng Rong, Yongfeng Zheng, Lijun Fan
  • Patent number: 10918575
    Abstract: An intelligent dripping pill machine for continuous liquid solidification comprises: a feeding device (1), a material combining device (2), a homogenizing device (3), a dripping device (4) and a de-oiling device (5) sequentially connected via a transmission channel. The intelligent dripping pill machine removes, via high-speed centrifugation, a cooling liquid attached to dripping pills, and each component device is connected compactly, thereby achieving a continuous manufacturing operation, and reducing an occupied space of the devices as a whole while ensuring the yield of the dripping pills.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: February 16, 2021
    Assignee: Tasly Pharmaceutical Group Co., LTD.
    Inventors: Kaijing Yan, Xiaobing Sun, Changsheng Rong, Xuefei Cai, Liang Wang
  • Patent number: 10874636
    Abstract: Disclosed is an application of substituted cinnamamide derivatives in the preparation of anti-anxiety medications, the substituted cinnammide derivatives are compounds having the structure of formula (I) or pharmaceutically acceptable salts thereof, wherein, R1 is —H, —OH, —F, —Cl, —Br, —I, —OCH3, —OCF3, —OCHF2, —OCH2F, —CF3, —CHF2, —CH2F, —CH3, —CH3CH2, —CF3CH2, —CN, —NO2, —NH2 or —COOR5; R2 is H, C1-C10 linear alkyl, C3-C10 branched alkyl, C3-C10 cyclic alkyl, C1-C10 hydroxyalkyl or a N-substituted piperazine-derived group; or R2 is a group forming with adjacent Y a tetrahydropyrrolyl group, a piperidyl group or a cyclohexanimido group.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: December 29, 2020
    Assignee: Tasly Pharmaceutical Group Co., Ltd.
    Inventors: Min Han, Xiaohui Ma, Wangyi Zhou, Yanyong Liu, Yanchuan Li, Jing Wang, Shuiping Zhou, He Sun, Yonghong Zhu
  • Patent number: 10813840
    Abstract: An intelligent continuous manufacturing method via liquid cooling of dripping pills comprises the following steps: (1) feeding: weighing and transferring multiple materials respectively; (2) material combining: performing staged heating on the materials transferred in step (1), and mixing the same to obtain a material mixture, wherein an RSD of an effective ingredient in the material mixture ?5%; (3) homogenizing: pressurizing the material mixture obtained in step (2), and increasing the temperature, so as to obtain a homogenized material having the RSD of the effective ingredient in the material mixture ?5%; (4) dripping: performing vibration dripping on the homogenized material obtained in step (3) to obtain dripping pills, delivering the dripping pills into a cooling liquid to be cooled and then transferred; and (5) de-oiling: removing the cooling liquid on surfaces of the dripping pills obtained in step (4) via tilting centrifugation.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: October 27, 2020
    Assignee: TASLY PHARMACEUTICAL GROUP CO., LTD.
    Inventors: Kaijing Yan, Xiaobing Sun, Changsheng Rong, Xuefei Cai, Liang Wang
  • Patent number: 10626077
    Abstract: The present invention relates to the medical field, specifically a salvianolic acid T as described in structural formula (I), a chiral isomer thereof, a preparation method therefor, pharmaceutical compositions, antioxidants, and free radical scavengers thereof, and a use of the compound.
    Type: Grant
    Filed: August 26, 2014
    Date of Patent: April 21, 2020
    Assignee: Tasly Pharmaceutical Group Co., LTD.
    Inventors: Shuiping Zhou, Wei Li, Yuanpeng Jin, Xinxin Li, Xiaohui Ma, Wei Zhou, Min Han, Shuming Li
  • Patent number: 10507197
    Abstract: Disclosed is a pharmaceutical composition containing silibinin, which is prepared from the following bulk drugs by weight ratio: 8.75-60 parts of silibinin, 15-65 parts of phospholipid, and 25-200 parts of Pu'er tea extract. The drug has the function of treating non-alcoholic fatty liver.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: December 17, 2019
    Assignee: Tasly Pharmaceutical Group Co., Ltd.
    Inventors: Naifeng Wu, Xijun Yan, He Sun, Kaijing Yan, Yonghong Zhu, Shunnan Zhang, Xiaolin Bai, Yi He, Xiaohui Ma, Ting Li, Lei Li
  • Publication number: 20190274962
    Abstract: The present invention relates to a preparation method for a traditional Chinese medicine drop pill and a traditional Chinese medicine micro drop pill prepared by using the method, and in particular, the present invention relates to a micro drop pill preparation method with high drug-loading capacity, simple preparation process and high production rate and a micro drop pill prepared by using the method. Specially, The drop pill preparation method used comprises the following steps: (1) material melting step: heat melting a medicine and a drop pill matrix to obtain a molten medicine liquid; (2) dropping step: delivering the molten medicine liquid to a dripper, and acquiring medicine drops of the molten medicine liquid by means of vibration dropping; and, (3) condensation step: cooling the medicine drops with a cooling gas to obtain micro drop pills.
    Type: Application
    Filed: May 24, 2019
    Publication date: September 12, 2019
    Applicant: TASLY PHARMACEUTICAL GROUP CO., LTD.
    Inventors: Xijun Yan, Naifeng Wu, Kaijing Yan, Xiaobing Sun, Shunnan Zhang, Zhengliang Ye, Hai'ou Dong, Hongbo Zhang, Wensheng Zhang, Lihong Zhou, Chenming Li, Cong Chen, Xiaofeng Liu, Shiqing Wang, Changsheng Rong, Yongfeng Zheng, Lijun Fan
  • Patent number: 10376490
    Abstract: A pharmaceutical composition for treating non-alcoholic fatty liver diseases consists of a silybin-phospholipid complex preparation and Pu'er tea/tea product according to a weight ratio of 0.5-2.5:0.3-10, wherein the silybin-phospholipid complex capsule preparation and the Pu'er teat/tea product are separately packaged.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: August 13, 2019
    Assignee: Tasly Pharmaceutical Group Co., Ltd.
    Inventors: Naifeng Wu, Xijun Yan, He Sun, Kaijing Yan, Yonghong Zhu, Shunnan Zhang, Xiaolin Bai, Yi He, Xiaohui Ma, Ting Li
  • Patent number: 10376491
    Abstract: Disclosed are a pharmaceutical composition for treating non-alcoholic fatty liver and a method for preparing same. The composition is prepared from the following hulk drugs by weight ratio: 8.75-60 parts of silibinin, 15-65 parts of phospholipid, 25-200 parts of Pu'er tea extract, and 5-50 parts of radix puerariae extract.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: August 13, 2019
    Assignee: Tasly Pharmaceutical Group Co., Ltd.
    Inventors: Xijun Yan, Naifeng Wu, He Sun, Kaijing Yan, Yonghong Zhu, Xiaohui Ma, Shunnan Zhang, Changwen Li, Xiaolin Bai, Ting Li, Lei Li, Yi He
  • Patent number: 10314923
    Abstract: A silybin injection contains silybin, sulfobutyl ether-?-cyclodextrin, an organic solvent for injection, a pH regulator, and may further contain a co-solvent, a lyophilization bulking agent, and water for injection.
    Type: Grant
    Filed: December 24, 2015
    Date of Patent: June 11, 2019
    Assignee: Tasly Pharmaceutical Group Co., Ltd.
    Inventors: Jianming Chen, Baoan Gao, Qinqin Zhou, Shuiping Zhou, Nan Cai, Yuansheng Zhang, Chan Wu, Nong Yu, Lina Chen, Wenli Liu
  • Patent number: 10307395
    Abstract: A pharmaceutical composition for treating non-alcoholic fatty liver diseases. The pharmaceutical composition is prepared from 8.75-60 parts by weight of silybin, 15-65 parts by weight of phospholipid, 25-150 parts by weight of a Pu'er tea extract, and 10.425-60 parts by weight of L-carnitine.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: June 4, 2019
    Assignee: Tasly Pharmaceutical Group Co., Ltd.
    Inventors: He Sun, Xijun Yan, Naifeng Wu, Kaijing Yan, Yonghong Zhu, Shunnan Zhang, Xiaolin Bai, Xiaohui Ma, Yi He, Ting Li, Lei Li
  • Patent number: 10307396
    Abstract: A pharmaceutical composition. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 8.75-60 parts of silybin, 15-65 parts of phospholipid, 25-200 parts of a Pu'er tea extract, 6.25-40 parts of vitamin E, and 8.3-60 parts of L-carnitine. The composition can be used for treating non-alcoholic fatty liver diseases.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: June 4, 2019
    Assignee: Tasly Pharmaceutical Group Co., Ltd.
    Inventors: He Sun, Xijun Yan, Naifeng Wu, Kaijing Yan, Yonghong Zhu, Shunnan Zhang, Xiaolin Bai, Xiaohui Ma, Yi He, Ting Li, Lei Li
  • Patent number: 10300030
    Abstract: A traditional Chinese medicine composition and preparation thereof for treating cardiovascular diseases is provided. The traditional Chinese medicine composition consists of: by weight percentage, phenolic acid derivatives 30%˜80%, tanshinones 2%˜10% and saponins 15%˜60%.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: May 28, 2019
    Assignee: Tasly Pharmaceutical Group Co., Ltd.
    Inventors: Xijun Yan, Naifeng Wu, Shunnan Zhang, Ping Li, Zhengliang Ye, Lihong Zhou, Lianwen Qi, Fenglian Zhang, Minchao Qi, Zhexuan Yang, Wei Sun, Jing Yu, Hua Yang, Peng Liu, Xiaohui Ma, Hai'ou Dong, Wensheng Zhang, Lanlan Zhang, Chenming Li
  • Patent number: 10111811
    Abstract: An air-cooling micro drop pill capsule production line comprises a drop pill system, an air-cooling circulation system and a control system. The drop pill system comprises a molten material tank and a dripper. A vibration apparatus is arranged between the molten material tank and the dripper, and drives the dripper to vibrate up and down. A vibration shear force cuts liquor flowing out from the dripper into drops, and drop pills are formed after the drops fall into the air-cooling circulation system and are cooled. An online monitoring apparatus is arranged on the dripper, and comprises a pulse signal emission mechanism with an emission frequency which is the same as a vibration frequency of the vibration apparatus. The control system controls and regulates a dropping parameter according to a monitoring result of the online monitoring apparatus.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: October 30, 2018
    Assignee: TASLY PHARMACEUTICAL GROUP CO., LTD.
    Inventors: Xijun Yan, Xiaobing Sun, Yongfeng Zheng, Lijun Fan, Yan Fu
  • Patent number: RE49035
    Abstract: A traditional Chinese medicine composition for treating cardiovascular disease, and a preparation thereof, particularly a micro drop pill preparation thereof, and a method for preparing the preparation; the method for preparing the micro drop pill preparation can be used to prepare drop pills, coated drop pills, and drop pill capsules with a high drug loading capacity.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: April 19, 2022
    Assignee: Tasly Pharmaceutical Group Co., Ltd.
    Inventors: Xijun Yan, Naifeng Wu, Kaijing Yan, Zhengliang Ye, Shunnan Zhang, Lihong Zhou, Wensheng Zhang, Hai'ou Dong
  • Patent number: RE49050
    Abstract: A traditional Chinese medicine composition for treating cardiovascular disease, and a preparation thereof, particularly a micro drop pill preparation thereof, and a method for preparing the preparation; the method for preparing the micro drop pill preparation can be used to prepare drop pills, coated drop pills, and drop pill capsules with a high drug loading capacity.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: April 26, 2022
    Assignee: Tasly Pharmaceutical Group Co., Ltd.
    Inventors: Xijun Yan, Naifeng Wu, Kaijing Yan, Zhengliang Ye, Shunnan Zhang, Lihong Zhou, Wensheng Zhang, Hai'ou Dong, Yongfeng Zheng, Lijun Fan