Abstract: A method of forming a sucrose-6-ester includes in sequence the steps of: a) contacting sucrose with a organotin-based acylation promoter in a solvent in the presence of a base selected from amines and basic alkali metal salts; b) removing water to form a tin-sucrose adduct; and c) contacting the tin-sucrose adduct with an acylating agent to form the sucrose-6-ester. The sucrose-6-ester may then be converted to sucralose.

Abstract: A method for the chlorination of a sucrose-6-acylate to produce a 4,1?,6?-trichloro-4,1?,6?-trideoxy-galactosucrose-?-acylate wherein said method comprises: (i) reacting the sucrose-6-acylate with a chlorinating agent in a reaction vehicle comprising a tertiary amide in order to chlorinate the 4, V and 6? positions of the sucrose-6-acylate; and (ii) quenching the product stream of (i) to produce a 4,1?,6?-trichloro-4,1?,6?-trideoxy-galactosucrose-6-acylate; wherein before said quenching, a portion of the tertiary amide is removed.

Abstract: A process for removing dimethylamine (DMA) before and/or during and/or after deacylation in a reaction vessel of a feed stream comprising a sucralose-6-acylate resulting from the chlorination of a sucrose-6-acylate in the presence of dimethyl formamide (DMF), wherein the deacylation is conducted at a first set of conditions of temperature, pH and pressure, the process comprising: (a) providing a side stream loop from and to the reaction vessel; (b) adjusting the conditions of one or more of temperature, pH, and pressure in the loop, and setting the flow rate through the loop, to remove DMA while minimising carbohydrate degradation.

Abstract: A method of forming a sucrose-6-ester includes in sequence the steps of: a) contacting sucrose with a organotinbased acylation promoter in a solvent in the presence of a base selected from amines and basic alkali metal salts; b) removing water to form a tin-sucrose adduct; and c) contacting the tin-sucrose adduct with an acylating agent to form the sucrose- 6-ester. The sucrose-6-ester may then be converted to sucralose.

Abstract: Methods of recovering a triarylmethyl halide from a sucrose derivatization process include the steps of (a) forming a mixture including 1) a triarylmethylated sucrose derivative including at least one triarylmethyl substituent and at least one acyl substituent on the sucrose, 2) triarylmethylated sucrose ester byproducts, and 3) an amine; (b) separating from the output of step (a) i) the triarylmethylated sucrose derivative, and ii) a mixture including the triarylmethylated sucrose ester byproducts and the amine; (c) removing the amine from the mixture of step (b) ii); (d) contacting the product of step (c) with hydrogen halide to cleave triarylmethyl groups and thereby form a crude triarylmethyl halide component; (e) contacting the crude triarylmethyl halide component with hydrogen halide to form a purified triarylmethyl halide component; and (f) recovering the triarylmethyl halide from the output of step (e).

Abstract: A method for the chlorination of a sucrose-6-acylate to produce a 4,1?,6?-trichloro-4,1?,6?-trideoxy-galactosucrose-?-acylate wherein said method comprises: (i) reacting the sucrose-6-acylate with a chlorinating agent in a reaction vehicle comprising a tertiary amide in order to chlorinate the 4, V and 6? positions of the sucrose-6-acylate; and (ii) quenching the product stream of (i) to produce a 4,1?,6?-trichloro-4,1?,6?-trideoxy-galactosucrose-6-acylate; wherein before said quenching, a portion of the tertiary amide is removed.

Abstract: Isolated microbial consortia capable of degrading chlorinated carbohydrates and a method to acclimatize microbes to degrade chlorinated carbohydrates under specific conditions of temperature and salt are described. Also described is a method for using microbial consortia to degrade chlorinated carbohydrates in a waste stream.

Abstract: The invention provides co-agglomerates of sucralose and a polyol, wherein the co-agglomerate comprises grains of polyol onto which sucralose has been dried, as well as methods for making such co-agglomerates. In general, the methods comprise contacting a dry powder of polyol with a liquid solution of sucralose in a food acceptable solvent under conditions which moisten, but not dissolve the polyol powder, to form a moist mixture, and drying the moist mixture to form a co-agglomerate comprising grains of agglomerated polyol onto which sucralose has been dried. Also provided are artificial sweetener carriers comprising bentonite which comprise sucralose. The invention features pharmaceutical, cosmetic, and food compositions, especially chewing gum, comprising a co-agglomerate of the invention, comprising a bentonite carrier, or comprising both.