Abstract: An extract obtained from Saxifraga sp., Astrantia major, or a combination thereof and a method of treating or relieving an inflammatory-skin related condition in a subject is provided. The method comprises administering or applying a composition comprising an effective amount of an extract from Saxifraga sp., Astrantia major or a combination thereof, and a carrier, wherein the effective amount of the extract inhibits tumor necrosis factor alpha and Interleukine-1beta activity. The inflammation may be inflammation of the skin and the composition may be a skin preparation for external use.