Patents Assigned to TCM
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Patent number: 11948693Abstract: The present disclosure provides a traditional Chinese medicine (TCM) syndrome classification method based on multi-graph attention, which comprehensively considers the contribution of symptoms and syndrome elements in syndrome classification by constructing a graph structure, integrates a symptom-symptom graph and a symptom-syndrome element graph into classification, uses a multi-graph attention network to aggregate the features of symptoms and syndrome elements, and finally realizes syndrome classification through a multi-layer perceptron. At the same time, extensive experiments are carried out on real data sets, the effectiveness of the multi-graph attention network is verified, more accurate classification is realized, and better classification results have been achieved.Type: GrantFiled: June 20, 2023Date of Patent: April 2, 2024Assignee: NANJING DAJING TCM INFORMATION TECHNOLOGY CO. LTDInventors: Jing Zhao, Wenyou Li, Zhaoyang Jiang, Jie Yin, Ying Chen
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Patent number: 11940011Abstract: A coupling member for use in priming a fluid pump of an internal combustion engine, the coupling member including a first end, a second end, and a cylindrical length therebetween. The first end of the coupling member may be configured to axially engage a drive shaft of a rotational drive, a plurality of fins may extend along at least a portion of the cylindrical length, and the plurality of fins may be configured to engage an oil drive gear of an internal combustion engine. Each fin from the plurality of fins may protrude radially from an outer surface of the coupling member, and the coupling member may be further configured to translate a rotational force provided by the rotational drive to the oil drive gear of the internal combustion engine.Type: GrantFiled: April 17, 2020Date of Patent: March 26, 2024Assignee: TCM Engine Products, LLCInventor: Mark Vinson
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Patent number: 11660285Abstract: Disclosed in the present invention is a new triptolide derivative as shown in formula (I). Also disclosed in the present invention are a preparation method for the compound and the medical use thereof in preparation of anti-cancer drugs. Triptolide acrylate of the present invention and a pharmaceutically acceptable salt thereof have anti-cancer activity, and after animal in-vivo experiments, can effectively inhibit tumor growth in animals. A plurality of in-vitro experiments proves that same can significantly increase the protein expression quantity of p53, promote the apoptosis of tumor cells, effectively inhibit the growth of the tumor cells, and have the effect of inhibiting metastasis of cancer cells. More importantly, the toxicity of the compound to normal cells is less than that of triptolide.Type: GrantFiled: December 30, 2019Date of Patent: May 30, 2023Assignees: Guangdong Provincial Hospital of TCM, The Second Affiliated Hospital Of Guangzhou University of Chinese Medicine, The Second Clinical College Of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy Of Chinese Medical SciencesInventors: Bo Liu, Xianzhang Huang, Zhimin Yang, Jun Li, Quanfu Chen, Liqiao Han, Hualun Liang, Yiqi Yang, Kai Wang, Xiaowan Wang, Ennian Li, Yi Wang, Runyue Huang, Yunshan Wu, Xiaodong Han, Jinlang Zhong, Bidan Zheng
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Patent number: 11445802Abstract: A computer-controlled system determines attributes of a frexel, an area of human skin, and applies a modifying agent (RMA) at the pixel level, typically to make the skin appear more youthful and so more attractive. The system scans the frexel, identifies unattractive attributes, and applies the RMA, typically with an inkjet printer. The identified attributes relate to reflectance and may refer to features such as irregular-looking light and dark spots, age-spots, scars, and bruises. Identified attributes may also relate to the surface topology of the skin, for more precisely enhancing surface irregularities such as bumps and wrinkles. Feature mapping may be used, for example to make cheeks appear pinker and cheekbones more prominent. The RMA can be applied in agreement with identified patterns, such as adding red to a red frexel, or in opposition, such as adding green or blue to a red frexel, according to idealized models of attractiveness.Type: GrantFiled: July 9, 2018Date of Patent: September 20, 2022Assignee: TCMS Transparent Beauty, LLCInventors: Albert D. Edgar, David C. Iglehart, Rick B. Yeager
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Patent number: 11401578Abstract: A method for extracting and separating Gold, Silver, Copper, Zinc and/or Lead from an Arsenic-containing ore, concentrate or tailings characterized in that the extraction is carried by roasting in the presence of a calcium-containing material and at least one of an alkali metal halide and alkaline metal halide. In the method, Arsenic remains immobilized in the extraction residue.Type: GrantFiled: November 10, 2017Date of Patent: August 2, 2022Assignee: TCM RESEARCH LTD.Inventors: Dmitri S. Terekhov, Colwyn S. van der Linde
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Patent number: 11319602Abstract: A probe combination for detecting cancer includes one or more sets of partial hepatitis B virus (HBV) targeting probes. When sequences of each of the sets of partial HBV targeting probes are aligned, an overall sequence of the aligned set of probes matches a reference sequence of a genome of a HBV genotype or a direct repeat (DR) region on the genome. In the aligned set of probes, each of the probes overlap with one or two adjacent probes by a portion of a length of the probe. The probe combination may further includes one or more sets of hotspot gene targeting probes targeting cancer hotspot genes such as CTNNB1, TERT, and TP53 genes, one or more sets of exogenous gene targeting probes targeting portions of a lambda phage genome, and endogenous gene targeting probes targeting endogenous genes such as GAPDH and GdX genes.Type: GrantFiled: January 31, 2018Date of Patent: May 3, 2022Assignee: TCM BIOTECH INTERNATIONL CORP.Inventors: You-Yu Lin, Ya-Chun Wang, Sheng-Tai Tzeng
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Patent number: 11202896Abstract: A system for controlling a tattoo machine configured to push ink includes a computerized processor configured to control a voltage supplied to the tattoo machine. The computerized processor includes programming configured to monitor a hand gesture input, determine a desired command for the tattoo machine based upon the monitored hand gesture input, and control the voltage supplied to the tattoo machine based upon the determined desired command. Monitoring the hand gesture input can include monitoring a touch-free hand gesture sensor.Type: GrantFiled: September 8, 2017Date of Patent: December 21, 2021Assignee: TCM Supply CorporationInventor: Rock Lee
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Patent number: 11147832Abstract: The present disclosure provides a use of pentosan polysulfate sodium (PPS) in the manufacture of a medicament for the prevention of recurrent urinary tract infection (rUTI) in a human subject, comprising a therapeutically effective dosage for oral administration of PPS, wherein the therapeutically effective dosage for oral administration of PPS is 5-1 mg/kg/day.Type: GrantFiled: April 24, 2020Date of Patent: October 19, 2021Assignee: TCM BIOTECH INTERNATIONAL CORP.Inventors: Ya-Chun Wang, Yu-Ching Chang, Hsiao Tien Ma, Jen-Yau Chen, Yuan-Ju Lee, En Meng, Shang-Jen Chang
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Patent number: 11147357Abstract: A computer-controlled system determines attributes of a frexel, an area of human skin, and applies a modifying agent (RMA) at the pixel level, typically to make the skin appear more youthful and so more attractive. The system scans the frexel, identifies unattractive attributes, and applies the RMA, typically with an inkjet printer. The identified attributes relate to reflectance and may refer to features such as irregular-looking light and dark spots, age-spots, scars, and bruises. Identified attributes may also relate to the surface topology of the skin, for more precisely enhancing surface irregularities such as bumps and wrinkles. Feature mapping may be used, for example to make cheeks appear pinker and cheekbones more prominent. The RMA can be applied in agreement with identified patterns, such as adding red to a red frexel, or in opposition, such as adding green or blue to a red frexel, according to idealized models of attractiveness.Type: GrantFiled: April 29, 2021Date of Patent: October 19, 2021Assignee: TCMS Transparent Beauty, LLCInventors: Albert D. Edgar, David C. Iglehart, Rick B. Yeager
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Patent number: 10842468Abstract: Disclosed herein is a sample collection apparatus. The sample collection apparatus includes a self-sampling pad and a cell fixing container, wherein the sample collection pad includes a filter unit, the structure and material of which are such that cells, viruses and DNAs contained in vaginal secretions can be efficiently absorbed and attached to the filter unit and can be efficiently detached from the filter unit in a cell preserving solution after the filter unit is removed and put into the cell preserving solution. Thus, the filter unit includes at least one adsorbent layer which is formed of a hydrophobic material having low fineness and high resilience.Type: GrantFiled: July 12, 2017Date of Patent: November 24, 2020Assignee: TCM BIOSCIENCES INC.Inventors: Young Chui Park, Hee Jae Joo, Dong Jin Shin
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Patent number: 10792134Abstract: A device for tooth shade measurement comprising a housing, a handle and a measuring head, characterized in that said measuring head includes a hollow body extending along a longitudinal axis, said hollow body comprising a proximal end, a bent distal end relative to the longitudinal axis, said distal end being provided with a removable tip designed to come into contact with a tooth surface to be analyzed, at least one light source and image acquisition means, integral with the hollow body, said hollow body being adapted to transmit the light from said light source from the proximal end up to the distal end, and in that said device comprises an orientation assembly for mounting the proximal end of the hollow body in the housing so that the measuring head occupies different angular positions relative to the housing.Type: GrantFiled: December 26, 2017Date of Patent: October 6, 2020Assignee: TCMInventors: Julien Guillot, Frédérik Rougier
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Patent number: 10796431Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for receiving an image of the area of the mouth. Identifying a feature of interest within the image. Determining an actual reflectance and an actual topology of the feature of interest. Determining a desired reflectance and a desired topology of the feature of interest. Calculating an amount of DCA to be applied to a portion of the feature of interest based on comparing the actual reflectance to the desired reflectance and the actual topology to the desired topology. Causing the calculated amount of DCA to be applied to the portion of the feature of interest.Type: GrantFiled: April 12, 2017Date of Patent: October 6, 2020Assignee: TCMS Transparent Beauty, LLCInventors: David C. Iglehart, Albert D. Edgar
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Patent number: 10553006Abstract: A method for guiding a user to manually apply cosmetics by overlaying graphical indicators on a real-time image of the user, the method including receiving a real-time image of the area of skin. Generating a registration layer containing a mapping between features of the real-time image and a graphical model of the area of skin. Presenting, for display to a user, a control layer overlaid on the real-time image according to the registration layer, the control layer including at least one indicator of a location on the area of skin where a reflectance modifying agent (RMA) should be applied. Determining, based on the real-time image, that the RMA has been applied to the location on the area of skin. In response to determining that the RMA has been applied to the location on the area of skin, modifying the at least one indicator included in the control layer.Type: GrantFiled: September 30, 2015Date of Patent: February 4, 2020Assignee: TCMS Transparent Beauty, LLCInventors: David C. Iglehart, Albert Durr Edgar
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Patent number: 10486174Abstract: A computer-controlled system determines attributes of a frexel, an area of human skin, and applies an electrostatically charged modifying agent (RMA) at the pixel level, to make the skin appear more attractive. The system scans the frexel, identifies unattractive attributes, charges the RMA with an electrostatic charger, and applies the RMA, typically with an inkjet printer. The identified attributes relate to reflectance and may refer to features such as irregular-looking light and dark spots, age-spots, scars, and bruises. Identified attributes may also relate to the surface topology of the skin, for more precisely enhancing surface irregularities. Feature mapping may be used, for example to make cheeks appear pinker and cheekbones more prominent. The charged RMA can be applied in agreement with identified patterns, such as adding red to a red frexel, or in opposition, such as adding green or blue to a red frexel, according to idealized models of attractiveness.Type: GrantFiled: February 12, 2008Date of Patent: November 26, 2019Assignee: TCMS Transparent Beauty LLCInventors: Albert D. Edgar, David C. Iglehart, Rick B Yeager
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Patent number: 10467779Abstract: A computer-controlled system determines attributes of a frexel, which is an area of human skin, and applies a reflectance modifying agent (RMA) at the pixel level to automatically change the appearance of human features based on one or more digital images. The change may be based on a digital image of the same frexel, for as seen in a prior digital photograph captured previously by the computer-controlled system. The system scans the frexel and uses feature recognition software to compare the person's current features in the frexel with that person's features in the digital image. It then calculates enhancements to the make the current features appear more like the features in the digital image, and it applies the RMA to the frexel to accomplish the enhancements. Or the change may be based on a digital image of another person, through the application of RMAs.Type: GrantFiled: December 4, 2018Date of Patent: November 5, 2019Assignee: TCMS Transparent Beauty LLCInventors: Albert D. Edgar, David C. Iglehart, Rick B. Yeager
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Patent number: 10421852Abstract: The invention relates to a preparation method of new-type nanoparticles for loading emodin, which comprises: using L.A, mPEG and stannous iso caprylate to synthesize a first intermediate product; using the first intermediate product, butanedioic anhydride and 4-dimethylaminopyridine to synthesize a second intermediate product; using the second intermediate product, 1-ethyl-(3-dimethylamino propyl) carbodiimide hydrochloride, N-hydroxysuccinimide and chitosan to synthesize a third intermediate product; using the third intermediate product and sodium periodate to synthesize a fourth intermediate product; using the fourth intermediate product and 5-amino-2-mercapto benzimidazole to synthesize the new-type thiolated nanoparticles. The nanoparticles loaded with emodin are used for intestinal tract dose, which may enhance the nanoparticles' adhesion ability, prolong residence time of drugs on mucosal membranes, and facilitate sustained-release of drug molecules.Type: GrantFiled: November 16, 2017Date of Patent: September 24, 2019Assignee: GUANGDONG PROVINCIAL HOSPITAL OF TCMInventors: Xusheng Liu, Qizhan Lin, Chuan Zou, Fuhua Lu, Zhaoyu Lu, Xiuqing Wu, Yuchi Wu, Chunlan Ji
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Publication number: 20190080451Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for receiving an image of the area of the mouth. Identifying a feature of interest within the image. Determining an actual reflectance and an actual topology of the feature of interest. Determining a desired reflectance and a desired topology of the feature of interest. Calculating an amount of DCA to be applied to a portion of the feature of interest based on comparing the actual reflectance to the desired reflectance and the actual topology to the desired topology. Causing the calculated amount of DCA to be applied to the portion of the feature of interest.Type: ApplicationFiled: April 12, 2017Publication date: March 14, 2019Applicant: TCMS Transparent Beauty, LLCInventors: David C. Iglehart, Albert D. Edgar
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Patent number: 10163230Abstract: A computer-controlled system determines attributes of a frexel, which is an area of human skin, and applies a reflectance modifying agent (RMA) at the pixel level to automatically change the appearance of human features based on one or more digital images. The change may be based on a digital image of the same frexel, for as seen in a prior digital photograph captured previously by the computer-controlled system. The system scans the frexel and uses feature recognition software to compare the person's current features in the frexel with that person's features in the digital image. It then calculates enhancements to the make the current features appear more like the features in the digital image, and it applies the RMA to the frexel to accomplish the enhancements. Or the change may be based on a digital image of another person, through the application of RMAs.Type: GrantFiled: July 6, 2018Date of Patent: December 25, 2018Assignee: TCMS Transparent Beauty LLCInventors: Albert D. Edgar, David C. Iglehart, Rick B. Yeager
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Patent number: 10092082Abstract: One or more reflectance modifying agent (RMA) such as a pigmented cosmetic agent is applied selectively and precisely with a controlled spray to human skin according to local skin reflectance or texture attributes. One embodiment uses digital control based on the analysis of camera images. Another embodiment, utilizes a calibrated scanning device comprising a plurality of LEDs and photo diode sensors to correct reflectance readings to compensate for device distance and orientation relative to the skin. Ranges of desired RMA application parameters of high luminance RMA, selectively applied to middle spatial frequency features, at low opacity or application density are each significantly different from conventional cosmetic practice. The ranges are complementary and the use of all three techniques in combination provides a surprisingly effective result which preserves natural beauty while applying a minimum amount of cosmetic agent.Type: GrantFiled: May 29, 2008Date of Patent: October 9, 2018Assignee: TCMS Transparent Beauty LLCInventors: Albert D. Edgar, Thomas E. Rabe, David C. Iglehart, Rick B. Yeager
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Patent number: 10043292Abstract: A computer-controlled system determines attributes of a frexel, which is an area of human skin, and applies a reflectance modifying agent (RMA) at the pixel level to automatically change the appearance of human features based on one or more digital images. The change may be based on a digital image of the same frexel, for as seen in a prior digital photograph captured previously by the computer-controlled system. The system scans the frexel and uses feature recognition software to compare the person's current features in the frexel with that person's features in the digital image. It then calculates enhancements to the make the current features appear more like the features in the digital image, and it applies the RMA to the frexel to accomplish the enhancements. Or the change may be based on a digital image of another person, through the application of RMAs.Type: GrantFiled: September 19, 2016Date of Patent: August 7, 2018Assignee: TCMS Transparent Beauty LLCInventors: Albert D. Edgar, David C. Iglehart, Rick B. Yeager