Patents Assigned to TCM
  • Patent number: 11992513
    Abstract: A traditional Chinese medicine composition for treating hand-foot syndrome after targeted drug treatment is mainly prepared from the following components by weight: 20-50 parts of Radix Sophorae Flavescentis, 20-50 parts of Herba Taraxaci, 20-50 parts of Flos Chrysanthemi Indici, and 20-50 parts of Herba Cum Radice Violae Yedoensitis, 20-50 parts of Rhizoma Smilacis Glabrae, 30-60 parts of Radix Astragali Seu Hedysari, 10-35 parts of Kochia scoparia (L.) Schrad, 10-45 parts of Carthamus tinctorius L., 15-45 parts of Cortex Radicis Dictamni Dasycarpi, 5-15 parts of Herba Ephedrae, 5-25 parts of Angelica sinensis, 5-25 parts of Rhizoma Ligustici Chuangxiong, 10-30 parts of Radix Rehmanniae, 5-15 parts of Ramulus cinnamomi, 10-30 parts of Cynanchum otophyllum Schneid, 5-15 parts of Semen Sinapis Albae, 5-20 parts of Arisaema heterophyllum Blume, 5-20 parts of Typhonium blumei Nicolson & Sivadasan, and 10-40 parts of Radix Glycyrrhizae.
    Type: Grant
    Filed: September 27, 2022
    Date of Patent: May 28, 2024
    Assignee: THE AFFILIATED HOSPITAL OF JIANGXI UNIVERSITY OF TCM
    Inventors: Qi Dai, Kunshan Chen, Xiaoqi Zhou
  • Patent number: 11948693
    Abstract: The present disclosure provides a traditional Chinese medicine (TCM) syndrome classification method based on multi-graph attention, which comprehensively considers the contribution of symptoms and syndrome elements in syndrome classification by constructing a graph structure, integrates a symptom-symptom graph and a symptom-syndrome element graph into classification, uses a multi-graph attention network to aggregate the features of symptoms and syndrome elements, and finally realizes syndrome classification through a multi-layer perceptron. At the same time, extensive experiments are carried out on real data sets, the effectiveness of the multi-graph attention network is verified, more accurate classification is realized, and better classification results have been achieved.
    Type: Grant
    Filed: June 20, 2023
    Date of Patent: April 2, 2024
    Assignee: NANJING DAJING TCM INFORMATION TECHNOLOGY CO. LTD
    Inventors: Jing Zhao, Wenyou Li, Zhaoyang Jiang, Jie Yin, Ying Chen
  • Patent number: 11940011
    Abstract: A coupling member for use in priming a fluid pump of an internal combustion engine, the coupling member including a first end, a second end, and a cylindrical length therebetween. The first end of the coupling member may be configured to axially engage a drive shaft of a rotational drive, a plurality of fins may extend along at least a portion of the cylindrical length, and the plurality of fins may be configured to engage an oil drive gear of an internal combustion engine. Each fin from the plurality of fins may protrude radially from an outer surface of the coupling member, and the coupling member may be further configured to translate a rotational force provided by the rotational drive to the oil drive gear of the internal combustion engine.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: March 26, 2024
    Assignee: TCM Engine Products, LLC
    Inventor: Mark Vinson
  • Patent number: 11660285
    Abstract: Disclosed in the present invention is a new triptolide derivative as shown in formula (I). Also disclosed in the present invention are a preparation method for the compound and the medical use thereof in preparation of anti-cancer drugs. Triptolide acrylate of the present invention and a pharmaceutically acceptable salt thereof have anti-cancer activity, and after animal in-vivo experiments, can effectively inhibit tumor growth in animals. A plurality of in-vitro experiments proves that same can significantly increase the protein expression quantity of p53, promote the apoptosis of tumor cells, effectively inhibit the growth of the tumor cells, and have the effect of inhibiting metastasis of cancer cells. More importantly, the toxicity of the compound to normal cells is less than that of triptolide.
    Type: Grant
    Filed: December 30, 2019
    Date of Patent: May 30, 2023
    Assignees: Guangdong Provincial Hospital of TCM, The Second Affiliated Hospital Of Guangzhou University of Chinese Medicine, The Second Clinical College Of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy Of Chinese Medical Sciences
    Inventors: Bo Liu, Xianzhang Huang, Zhimin Yang, Jun Li, Quanfu Chen, Liqiao Han, Hualun Liang, Yiqi Yang, Kai Wang, Xiaowan Wang, Ennian Li, Yi Wang, Runyue Huang, Yunshan Wu, Xiaodong Han, Jinlang Zhong, Bidan Zheng
  • Patent number: 11401578
    Abstract: A method for extracting and separating Gold, Silver, Copper, Zinc and/or Lead from an Arsenic-containing ore, concentrate or tailings characterized in that the extraction is carried by roasting in the presence of a calcium-containing material and at least one of an alkali metal halide and alkaline metal halide. In the method, Arsenic remains immobilized in the extraction residue.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: August 2, 2022
    Assignee: TCM RESEARCH LTD.
    Inventors: Dmitri S. Terekhov, Colwyn S. van der Linde
  • Patent number: 11319602
    Abstract: A probe combination for detecting cancer includes one or more sets of partial hepatitis B virus (HBV) targeting probes. When sequences of each of the sets of partial HBV targeting probes are aligned, an overall sequence of the aligned set of probes matches a reference sequence of a genome of a HBV genotype or a direct repeat (DR) region on the genome. In the aligned set of probes, each of the probes overlap with one or two adjacent probes by a portion of a length of the probe. The probe combination may further includes one or more sets of hotspot gene targeting probes targeting cancer hotspot genes such as CTNNB1, TERT, and TP53 genes, one or more sets of exogenous gene targeting probes targeting portions of a lambda phage genome, and endogenous gene targeting probes targeting endogenous genes such as GAPDH and GdX genes.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: May 3, 2022
    Assignee: TCM BIOTECH INTERNATIONL CORP.
    Inventors: You-Yu Lin, Ya-Chun Wang, Sheng-Tai Tzeng
  • Patent number: 11202896
    Abstract: A system for controlling a tattoo machine configured to push ink includes a computerized processor configured to control a voltage supplied to the tattoo machine. The computerized processor includes programming configured to monitor a hand gesture input, determine a desired command for the tattoo machine based upon the monitored hand gesture input, and control the voltage supplied to the tattoo machine based upon the determined desired command. Monitoring the hand gesture input can include monitoring a touch-free hand gesture sensor.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: December 21, 2021
    Assignee: TCM Supply Corporation
    Inventor: Rock Lee
  • Patent number: 11147832
    Abstract: The present disclosure provides a use of pentosan polysulfate sodium (PPS) in the manufacture of a medicament for the prevention of recurrent urinary tract infection (rUTI) in a human subject, comprising a therapeutically effective dosage for oral administration of PPS, wherein the therapeutically effective dosage for oral administration of PPS is 5-1 mg/kg/day.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: October 19, 2021
    Assignee: TCM BIOTECH INTERNATIONAL CORP.
    Inventors: Ya-Chun Wang, Yu-Ching Chang, Hsiao Tien Ma, Jen-Yau Chen, Yuan-Ju Lee, En Meng, Shang-Jen Chang
  • Patent number: 10842468
    Abstract: Disclosed herein is a sample collection apparatus. The sample collection apparatus includes a self-sampling pad and a cell fixing container, wherein the sample collection pad includes a filter unit, the structure and material of which are such that cells, viruses and DNAs contained in vaginal secretions can be efficiently absorbed and attached to the filter unit and can be efficiently detached from the filter unit in a cell preserving solution after the filter unit is removed and put into the cell preserving solution. Thus, the filter unit includes at least one adsorbent layer which is formed of a hydrophobic material having low fineness and high resilience.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: November 24, 2020
    Assignee: TCM BIOSCIENCES INC.
    Inventors: Young Chui Park, Hee Jae Joo, Dong Jin Shin
  • Patent number: 10792134
    Abstract: A device for tooth shade measurement comprising a housing, a handle and a measuring head, characterized in that said measuring head includes a hollow body extending along a longitudinal axis, said hollow body comprising a proximal end, a bent distal end relative to the longitudinal axis, said distal end being provided with a removable tip designed to come into contact with a tooth surface to be analyzed, at least one light source and image acquisition means, integral with the hollow body, said hollow body being adapted to transmit the light from said light source from the proximal end up to the distal end, and in that said device comprises an orientation assembly for mounting the proximal end of the hollow body in the housing so that the measuring head occupies different angular positions relative to the housing.
    Type: Grant
    Filed: December 26, 2017
    Date of Patent: October 6, 2020
    Assignee: TCM
    Inventors: Julien Guillot, Frédérik Rougier
  • Patent number: 10421852
    Abstract: The invention relates to a preparation method of new-type nanoparticles for loading emodin, which comprises: using L.A, mPEG and stannous iso caprylate to synthesize a first intermediate product; using the first intermediate product, butanedioic anhydride and 4-dimethylaminopyridine to synthesize a second intermediate product; using the second intermediate product, 1-ethyl-(3-dimethylamino propyl) carbodiimide hydrochloride, N-hydroxysuccinimide and chitosan to synthesize a third intermediate product; using the third intermediate product and sodium periodate to synthesize a fourth intermediate product; using the fourth intermediate product and 5-amino-2-mercapto benzimidazole to synthesize the new-type thiolated nanoparticles. The nanoparticles loaded with emodin are used for intestinal tract dose, which may enhance the nanoparticles' adhesion ability, prolong residence time of drugs on mucosal membranes, and facilitate sustained-release of drug molecules.
    Type: Grant
    Filed: November 16, 2017
    Date of Patent: September 24, 2019
    Assignee: GUANGDONG PROVINCIAL HOSPITAL OF TCM
    Inventors: Xusheng Liu, Qizhan Lin, Chuan Zou, Fuhua Lu, Zhaoyu Lu, Xiuqing Wu, Yuchi Wu, Chunlan Ji
  • Patent number: 10036761
    Abstract: A cell smearing apparatus comprising: a mixed solution container accommodation unit accommodating a mixed solution container containing a mixed solution of cells and a preservation solution; a suction unit suctioning the mixed solution from the mixed solution container accommodated in the mixed solution container accommodation unit; a sensor unit sensing variation of the mixed solution suctioned by the suction unit; and a controller controlling a suctioning speed of the suction unit based on a value sensed by the sensor unit. The present invention allows cells to be examined to be smeared as a monolayer on a slide for microscopic examination.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: July 31, 2018
    Assignee: TCM BIOSCIENCES INC.
    Inventors: Young Chul Park, Hee Jae Joo, Dong Jin Shin
  • Publication number: 20180161132
    Abstract: A device for tooth shade measurement comprising a housing, a handle and a measuring head, characterized in that said measuring head includes a hollow body extending along a longitudinal axis, said hollow body comprising a proximal end, a bent distal end relative to the longitudinal axis, said distal end being provided with a removable tip designed to come into contact with a tooth surface to be analyzed, at least one light source and image acquisition means, integral with the hollow body, said hollow body being adapted to transmit the light from said light source from the proximal end up to the distal end, and in that said device comprises an orientation assembly for mounting the proximal end of the hollow body in the housing so that the measuring head occupies different angular positions relative to the housing.
    Type: Application
    Filed: December 26, 2017
    Publication date: June 14, 2018
    Applicant: TCM
    Inventors: Julien Guillot, Frédérik Rougier
  • Patent number: 9945879
    Abstract: A cell smearing apparatus comprising: a mixed solution container accommodation unit accommodating a mixed solution container containing a mixed solution of cells and a preservation solution; a suction unit suctioning the mixed solution from the mixed solution container accommodated in the mixed solution container accommodation unit; a sensor unit sensing variation of the mixed solution suctioned by the suction unit; and a controller controlling a suctioning speed of the suction unit based on a value sensed by the sensor unit. The present invention allows cells to be examined to be smeared as a monolayer on a slide for microscopic examination.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: April 17, 2018
    Assignee: TCM KOREA, INC.
    Inventors: Young Chul Park, Hee Jae Joo, Dong Jin Shin
  • Patent number: 9938453
    Abstract: Composition and methods using the compositions are disclosed, where the compositions include heterocyclic aromatic amines, substituted heterocyclic aromatic amines, poly vinyl heterocyclic aromatic amines, co-polymers of vinyl heterocyclic aromatic amine and non amine polymerizable monomers (ethylenically unsaturated mononers and diene monomers), or mixtures or combinations thereof reacted with sulfonic acids, alkyl sulfonic acids, sulfosuccinates, sulfamic acids, sulfuric acids or partially neutralized amine or other alkali sulfonate and/or reacted with alpha hydroxyl carboxcylic acids which form coatings that alter self-aggregating properties and/or aggregation propensities of the particles and surfaces. Furthermore, the coating can be used to improve filtration of fluids through particulate matter and it is found that the coating will increase hydrocarbon liquid and gas flow through or over treated particulates and surfaces.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: April 10, 2018
    Assignee: Sumisaujana TCM Chemicals Sdn. Bhd.
    Inventors: Raynard Veldman, Arthur Thomas Gilmer, Mohammad Zaki Hasra Shafie, Norazlam Norbi
  • Patent number: 9932520
    Abstract: Composition and methods using the compositions are disclosed, where the compositions include heterocyclic aromatic amines, substituted heterocyclic aromatic amines, poly vinyl heterocyclic aromatic amines, co-polymers of vinyl heterocyclic aromatic amine and non amine polymerizable monomers (ethylenically unsaturated mononers and diene monomers), or mixtures or combinations thereof reacted with sulfonic acids, alkyl sulfonic acids, sulfosuccinates, sulfamic acids, sulfuric acids or partially neutralized amine or other alkali sulfonate and/or reacted with alpha hydroxyl carboxcylic acids which form coatings that alter self-aggregating properties and/or aggregation propensities of the particles and surfaces. Furthermore, the coating can be used to improve filtration of fluids through particulate matter and it is found that the coating will increase hydrocarbon liquid and gas flow through or over treated particulates and surfaces.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: April 3, 2018
    Assignee: Sumisaujana TCM Chemicals Sdn. Bhd.
    Inventors: Raynard Veldman, Arthur Thomas Gilmer, Mohammad Zaki Hasra Shafie, Norazlam Norbi
  • Patent number: 9914873
    Abstract: Composition and methods using the compositions are disclosed, where the compositions include heterocyclic aromatic amines, substituted heterocyclic aromatic amines, poly vinyl heterocyclic aromatic amines, co-polymers of vinyl heterocyclic aromatic amine and non amine polymerizable monomers (ethylenically unsaturated mononers and diene monomers), or mixtures or combinations thereof reacted with sulfonic acids, alkyl sulfonic acids, sulfosuccinates, sulfamic acids, sulfuric acids or partially neutralized amine or other alkali sulfonate and/or reacted with alpha hydroxyl carboxcylic acids which form coatings that alter self-aggregating properties and/or aggregation propensities of the particles and surfaces. Furthermore, the coating can be used to improve filtration of fluids through particulate matter and it is found that the coating will increase hydrocarbon liquid and gas flow through or over treated particulates and surfaces.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: March 13, 2018
    Assignee: Sumisaujana TCM Chemicals Sdn. Bhd.
    Inventors: Raynard Veldman, Arthur Thomas Gilmer, Mohammad Zaki Hasra Shafie, Norazlam Norbi
  • Patent number: 9573305
    Abstract: A device for producing a silicone rubber cupping appliance is provided. The device includes a nozzle, an internal mould core, a separable slide comprising at least two separable slide blocks; and a blowing-demoulding unit. A mould cavity used for moulding the silicone rubber cupping appliance is formed between the slide and the internal mould core. One end of the nozzle is connected to a channel that transports liquid silicone rubber material, and another end of the nozzle is connected to the mould cavity. The blowing-demoulding unit is connected to the mould cavity through a blow duct opening which is set at a contact surface of the internal mould core and the mould cavity.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: February 21, 2017
    Assignee: Green Island International TCM Group Limited
    Inventor: Bing Yuan
  • Patent number: 9550938
    Abstract: Composition and methods using the compositions are disclosed, where the compositions include heterocyclic aromatic amines, substituted heterocyclic aromatic amines, poly vinyl heterocyclic aromatic amines, co-polymers of vinyl heterocyclic aromatic amine and non amine polymerizable monomers (ethylenically unsaturated mononers and diene monomers), or mixtures or combinations thereof reacted with sulfonic acids, alkyl sulfonic acids, sulfosuccinates, sulfamic acids, sulfuric acids or partially neutralized amine or other alkali sulfonate and/or reacted with alpha hydroxyl carboxcylic acids which form coatings that alter self-aggregating properties and/or aggregation propensities of the particles and surfaces. Furthermore, the coating can be used to improve filtration of fluids through particulate matter and it is found that the coating will increase hydrocarbon liquid and gas flow through or over treated particulates and surfaces.
    Type: Grant
    Filed: December 2, 2014
    Date of Patent: January 24, 2017
    Assignee: Sumisaujana TCM Chemicals Sdn. Bhd.
    Inventors: Raynard Veldman, Arthur Thomas Gilmer, Mohammad Zaki Hasra Shafie, Norazlam Norbi
  • Publication number: 20170000591
    Abstract: A method for manufacturing and controlling the conformity of a dental prosthesis from parameters obtained intra-orally with a shade selecting device is described herein. The method includes: selecting the shade of the client tooth to be replaced or restored by the practitioner using the practitioner's shade selecting DPraticien device, with local storage of such data, transmitting these data to a practitioner's computer station equipped with software for visualizing the measurement data and possibly with software for entering the client's contact information and specific data, both software programs being advantageously combined, transmitting these data to a dental technician's computer station, manufacturing by the dental technician of the prosthesis according to the data received from the practitioner, controlling the prosthesis data using a dental technician's shade selecting DProthésiste device, self-calibrated in the same way as the DPraticien device, and sending the prosthesis to the practitioner.
    Type: Application
    Filed: August 27, 2015
    Publication date: January 5, 2017
    Applicant: TCM
    Inventors: Julien Guillot, Frédérik Rougier