Patents Assigned to TDW Group
  • Engineered chimeric pegylated ADI and methods of use
    Patent number: 10463721
    Abstract: Provided are chimeric arginine deiminases, including pegylated chimeric arginine deiminases, and related compositions and methods of use thereof, including methods of treating cancer.
    Type: Grant
    Filed: March 18, 2015
    Date of Patent: November 5, 2019
    Assignee: TDW Group
    Inventors: Bor-Wen Wu, Robert Almassy, Wei He, Richard E. Showalter, Jiaojuan He, Yunyun Guo, James A. Thomson
  • Antibodies to argininosuccinate synthase and related methods
    Patent number: 9938355
    Abstract: Antibodies, and antigen-binding fragments, which specifically bind to argininosuccinate synthase, and related compositions, kits, and methods of use, which are useful as companion diagnostics to identify suitable subjects for arginine deprivation or depletion therapies such as ADI-PEG 20 and other arginine deiminase (ADI) polypeptide-based therapies.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: April 10, 2018
    Assignee: TDW Group
    Inventors: Wei He, Yunyun Guo, Bor-Wen Wu