Abstract: A nanonization method for cannabidiol (CBD) includes following steps: the CBD is dissolved in a good solvent to obtain a CBD-good solvent solution, the CBD-good solvent solution is added to aqueous solution of a stabilizer to obtain mixed solution, the mixed solution is ultrasonicated followed by removing the good solvent by rotary evaporation from the mixed solution to obtain a nanosized CBD suspension. The stabilizer includes one or more selected from the group consisting of poloxamer, tween, polyoxyethylene alkyl ether, polyvinyl pyrrolidone, hydroxypropyl methyl cellulose and carboxymethyl chitosan. Particle size of the CBD is reduced in the nanonization method for the CBD through the nanonization of insoluble drugs to obtain the nanosized CBD suspension. In the nanosized CBD suspension, nanosized CBD has high solid content. The nanonization method for the CBD achieves solubilization of the CBD.

Abstract: An insoluble transdermal microneedle patch, includes microneedles and a backing. The microneedles include bases and needlepoints located on the base, and materials made for the microneedles include crosslinked sodium alginate. The backing is connected with the bases, and parts of the backing corresponding to the needlepoints are hollow portions. The microneedle patch can act in the skin for a long time, during it is used for transdermal delivery, drugs can enter skin micropores to be absorbed into a body through pores formed after swelled microneedles acting on the skin absorbs water, thereby increasing a bioavailability of the drugs during the transdermal delivery. After drug administration end, the microneedles are completely removed without increasing a metabolic burden in the body, soluble materials are prevented from being accumulated in the body, and the microneedles have good biological safety. A preparation method of the insoluble transdermal microneedle patch and application thereof are provided.

Abstract: A method for measuring multiple parameters of mixed gases based on broadband infrared light source is provided, including: filtering a broadband infrared laser, and forming a laser beam including three narrow-linewidth wavelengths; dividing the laser beam into a first sub-laser beam and a second sub-laser beam; focusing and transmitting the first sub-laser beam to a gas sample cell; focusing and transmitting the first sub-laser beam to a first reflector; reflecting and transmitting the first sub-laser beam; reflecting and transmitting the second sub-laser beam to the second beam splitter; combing the first sub-laser beam transmitted by the second beam splitter and the second sub-laser beam reflected by the second beam splitter, measuring the multiple parameters; combining and transmitting the second sub-laser beam transmitted by the second beam splitter and the first sub-laser beam reflected by the second beam splitter to a spectrometer for measuring concentrations the mixed gases.

Abstract: A fiber optic sensing head includes a single-mode optical fiber, a twin hole optical fiber including a cladding region and a core region surrounded by the cladding region, and the core region includes a second core located at an axis center, as well as a first and second round holes symmetrically distributed with respect to the second core; an incoming end of a gradient refractive-index fiber is connected to an outgoing end of the twin hole optical fiber with the incoming end of the gradient index fiber aligned with the outgoing end of the single-mode optical fiber at center. A thermal-sensitive structure is filled in a preset length part of the second round hole extending along an axial direction of the twin hole optical fiber. An incoming end of the twin hole optical fiber is connected to an outgoing end of the gradient index optical fiber with displacement.

Abstract: The present invention relates to nonlinear optical crystals of compound Na3La9B8O27 and producing method and uses thereof. From the Na3La9B8O27 compound, large size single crystal of Na3La9B8O27 could be prepared by flux method. Na3La9B8O27 crystals are non-hygroscopic, and possess stronger nonlinear optical effect and good mechanical properties. They meet the requirements for the frequency conversion of blue—green wavelength lasers and could be used to prepare nonlinear optical devices.