Abstract: The present invention provides pharmaceutical compositions comprising membrane vesicles, including extracellular vesicles including those referred to as exosomes, loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor. Methods of treating neurological diseases, disorders or conditions using the extracellular vesicles are provided. Isolated extracellular vesicles loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor are provided as well.
Type:
Grant
Filed:
March 27, 2019
Date of Patent:
May 16, 2023
Assignees:
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LIMITTED, RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventors:
Shulamit Levenberg, Shaowei Guo, Daniel Offen, Nisim Perets