Patents Assigned to Technion Research & Development Foundation
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Patent number: 12293853Abstract: Provided herein are composite conductors, characterized by having copper deposits inside the bulk rather than on the outer surface of a non-metallic conductive porous matrix, such as CNT fabric, as well as a process for obtaining the same. The composite conductors provided herein are also characterized by a low specific weight and a high ampacity compared to metal conductors of similar size and shape.Type: GrantFiled: May 14, 2020Date of Patent: May 6, 2025Assignee: Technion Research & Development Foundation LimitedInventors: Yair Ein-Eli, Neta Yitzhack, Nina Sezin, David Starosvetsky
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Publication number: 20250136719Abstract: The present invention relates to an heparanase-binding and heparanase-neutralizing monoclonal antibody (IgG-1 mAb A54), including its epitope (HBD-II) and mode of interaction with heparanase, pharmaceutical composition comprising same, and uses thereof e.g. for inhibiting or treating a disease or disorder associated with heparanase activity, including but not limited to cancer, inflammation, viral infection, diabetes and related complications. The present invention further provides combinatorial cancer therapies, comprising the heparanase-neutralizing mAb and an additional anti-cancer treatment such as chemotherapy or radiation.Type: ApplicationFiled: September 25, 2024Publication date: May 1, 2025Applicants: Technion Research & Development Foundation Limited, Hadasit Medical Research Services and Development Ltd.Inventors: Israel Vlodavsky, Uri Barash
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Patent number: 12281601Abstract: A method for converting heat to mechanical work includes providing incoming heat transfer liquid (HTL) at a first temperature to a plurality of mixing chambers, providing incoming compressed gas at a second temperature to the plurality of mixing chamber, enabling the gas and the HTL to mix, producing a gas-and-HTL mix, enabling the HTL in the gas-and-HTL mix to heat the gas and isothermal expansion of the gas in the gas-and-HTL mix, limiting volume of the gas-and-HTL mix, thereby increasing pressure of the gas and causing acceleration of a flow of the gas-and-HTL mix, causing the gas-and-HTL mix to eject through a plurality of nozzles, thereby converting the heat of the HTL to kinetic energy to cause movement of the plurality of nozzles; and using the kinetic energy to produce mechanical work.Type: GrantFiled: January 24, 2024Date of Patent: April 22, 2025Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITEDInventors: Carmel Rotschild, Joseph Cassell
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Publication number: 20250122854Abstract: A direct gaseous reformate injector that includes an inlet for receiving a gaseous reformate; a plunger; and an outward-opening valve that comprises a valve body and a needle that is movable, by the plunger, in relation to the valve body, between a (a) closed position in which the gaseous reformate is not outputted from the direct gaseous reformate injector, and (b) an open position in which the gaseous reformate is outputted from the direct gaseous reformate injector.Type: ApplicationFiled: October 15, 2024Publication date: April 17, 2025Applicant: Technion Research & Development Foundation LimitedInventors: Leonid Tartakovsky, Asher Netzer Lichinitzer
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Patent number: 12274678Abstract: The present invention provides a pharmaceutical composition including a combination of at least two cannabinoids, and methods of using same, such as for treating a NOTCH 1-related disease.Type: GrantFiled: May 17, 2020Date of Patent: April 15, 2025Assignees: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED, RAMOT AT TEL-AVIV UNIVERSITY LTD.Inventors: David Meiri, Elazar Besser, Igal Louria-Hayon, Paula Berman, Gil Moshe Lewitus, Limor Broday
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Publication number: 20250114351Abstract: A method of treating a disease or disorder for which an increase in immune cells in the brain is therapeutic in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of an agent which specifically binds and increases activity of a receptor selected from the group consisting of a 5HT2C receptor, a 5HT2A receptor and a 5HT2B receptor in the postcentral gyrus and/or the choroid plexus (CP) of the brain of the subject. Compositions for treating these diseases are also disclosed.Type: ApplicationFiled: December 18, 2024Publication date: April 10, 2025Applicant: Technion Research & Development Foundation LimitedInventors: Asya ROLLS, Dorit FARFARA, Ben KORIN, Hilla AZULAY-DEBBY, Shahar ARMON
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Patent number: 12268101Abstract: Compositions comprising a) one or more amorphous superconductor layers bound to one or more flexible substrate layers, or b) one or more superconductor layers bound to one or more layers of a high dielectric material are disclosed. Furthermore, provided herein are articles comprising one or more compositions of the invention and method of manufacturing thereof.Type: GrantFiled: September 22, 2020Date of Patent: April 1, 2025Assignee: TECHNION RESEARCH &DEVELOPMENT FOUNDATION LIMITEDInventors: Yachin Ivry, Mohammad Suleiman
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Publication number: 20250101369Abstract: A method of preparing a composition comprising mycelium along with a cellulose and/or plurality of nanoparticles is described herein. The method comprises inoculating a liquid medium with fungus, the liquid medium comprising nutrients and the cellulose and/or nanoparticles. Further described herein are compositions comprising mycelium along with a cellulose and/or plurality of nanoparticles, as well as articles-of-manufacture comprising such a composition, wherein at least 10% of the cellulose and/or nanoparticles in the composition is incorporated within the mycelium. A method of enhancing fungal growth is also described, comprising contacting the fungus with a liquid medium comprising a polymer which comprises carboxylic acid groups.Type: ApplicationFiled: December 9, 2024Publication date: March 27, 2025Applicant: Technion Research & Development Foundation LimitedInventors: Noam ATTIAS, Jacob GROBMAN, Tiffany ABITBOL
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Publication number: 20250086788Abstract: A method for quantitative magnetic resonance imaging (MRI), the method includes (a) receiving a sequence of MRI images of an in vivo tissue, by an image registration deep neural network (DNN) module that was trained, by a training process, to impose one or more MRI signal related physical constraints on a content of the sequence of MRI images; and (b) extracting one or more quantitative map from the sequence of MRI images.Type: ApplicationFiled: August 14, 2024Publication date: March 13, 2025Applicants: Technion Research & Development Foundation Limited, MEDICAL RESEARCH & DEVELOPMENT FUND FOR HEALTH SERVICES, BNAI-ZION MEDICAL CENTERInventors: Mordechay Pinchas Freiman, Eyal Hanania, Israe Cohen
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Patent number: 12247231Abstract: Systems comprising a first polynucleotide comprising a regulatory element operatively linked to an open reading frame encoding an invertase enzyme and a second polynucleotide comprising a repressible regulatory element operatively linked to an open reading frame encoding a glucose oxidase enzyme wherein the repressible element inhibits transcription in response to hydrogen peroxide are provided. Cells and compositions comprising a system of the invention, as well as methods using the system of the invention, are also provided, as is artificial honey.Type: GrantFiled: October 18, 2021Date of Patent: March 11, 2025Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITEDInventors: Roee Amit, Shira Levi, Lidya Tannenzapf, Yehonatan Zur, Ilan Brajzblat, Assaf Licht, Ofri Warsha, Mai Dror, Dor Ben Meir, Lior Haim, Zeinat Awwad, Nir Litver, Tzila Davidov, Liron Abrahami Pachuk, Noa Eden, Hanriet Tibi, Orna Atar
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Publication number: 20250079018Abstract: A method including sensing local accelerations or changes in sensor position, including orientation and displacement, with a local acceleration sensor mounted on a chest or abdomen of a patient, and calculating energy of polyphasic motions, based on sensed information of the local acceleration sensor and classifying severity of cardiac decompensation by calculating an excessive energy index (EEi) that compares excessive energy that appears in the polyphasic motions to energy required for inspiration at a basic respiratory rate.Type: ApplicationFiled: November 14, 2024Publication date: March 6, 2025Applicants: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD., RAMBAM HEALTH CORPORATIONInventors: Amir Landesberg, Yakov Tsibulsky, Shmuel Rispler
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Patent number: 12241776Abstract: A system and method of detecting acoustic waves including directing a continuous-wave source laser beam to an optical resonator that is impinged by acoustic the waves. Optionally, the source laser beam can propagate through the optical resonator, thereby generating a propagated laser beam. Using an interferometer, the acoustic waves can be detected by monitoring transients in an optical phase of the propagated laser beam.Type: GrantFiled: September 19, 2023Date of Patent: March 4, 2025Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITEDInventors: Amir Rozental, Lucas Riobo, Yoav Hazan
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Patent number: 12230306Abstract: A method, comprising: providing an electrical energy source having a specified amount of electrical energy; connecting an array comprising n magnetic tunnel junctions (MTJ) in parallel to said electrical energy source, wherein each of said MTJs is at a high resistance initial state; discharging said specified energy amount through said MTJs, thereby causing a random subset of said MTJs to switch to a lower resistance state; determining a post-discharging resistance state of each of the MTJs; and assigning a logical state to each of said MTJs corresponding to said resistance state of said MTJ.Type: GrantFiled: December 2, 2019Date of Patent: February 18, 2025Assignee: TECHNION RESEARCH &DEVELOPMENT FOUNDATION LIMITEDInventors: Shahar Kvatinsky, Ben Perach
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Publication number: 20250051348Abstract: Mechanophoric compounds featuring one or more, or two or more, clickable group(s), which are capable of being coupled to naturally occurring, synthetic and/or metallic substrates via Click chemistry, method of preparing mechanophoric matrices using the mechanophoric compounds, and mechanophoric matrices obtainable thereby, and uses thereof for detecting force-induced damage in the matrices by a colorimetric change are provided.Type: ApplicationFiled: August 13, 2024Publication date: February 13, 2025Applicant: Technion Research & Development Foundation LimitedInventors: Joshua M. GROLMAN, Yifan LIAO, Hang ZHANG, Charles Eliezer DIESENDRUCK
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Patent number: 12220246Abstract: A method comprising: generating a parametrized three-dimensional (3D) body surface model on a training set comprising a plurality of 3D scans of subjects, wherein at least some of said 3D scans are of subjects having a skeletal deformity; receiving one or more target 3D scans of a target subject; optimizing said body surface model with respect to said one or more target 3D scans to calculate a target body surface model of said target subject; training a skeletal estimation model on a training set comprising: (i) body surface models of a plurality of subjects, and (ii) skeletal landmarks sets of said plurality of subjects; and applying said trained skeletal estimation model to said calculated target body surface model of said target subject, to estimate a skeletal shape of said target subject.Type: GrantFiled: May 1, 2024Date of Patent: February 11, 2025Assignees: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED, NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED, MAINTAINING THE HOSPITAL FOR SPECIAL SURGERYInventors: Ron Kimmel, Benjamin Groisser, Alon Wolf, Roger F. Widmann, Howard J. Hillstrom
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Publication number: 20250041275Abstract: The invention relates generally to the field of compositions including one or more conjugates of di-sugar and a nonsteroidal anti-inflammatory drug (NSAID), and use of same in methods for treating a disease or a disorder in a subject in need thereof.Type: ApplicationFiled: October 10, 2024Publication date: February 6, 2025Applicants: RAMBAM MED-TECH LTD., TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITEDInventors: Iyad KHAMAYSI, Salim HADAD, Zaid ABASSI
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Patent number: 12217884Abstract: Protein based highly stretchable compositions with ionic conductivity are disclosed herein. Methods for preparing such compositions are also disclosed.Type: GrantFiled: October 29, 2020Date of Patent: February 4, 2025Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITEDInventors: Nadav Amdursky, Ramesh Nandi
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Publication number: 20250027868Abstract: An atomic interferometer system comprises optical tweezers each configured to trap at least one atom therein, an atom source system configured to release atoms, and a controller configured to control the optical tweezers to trap at least one atom released by the atom source system in one of the tweezers, to spatially split a wave function of the trapped atom between at least two of the tweezers, and to at least partially recombine the split atomic wave function in at least one of the tweezers. The atomic interferometer system can also comprise a measuring system configured to measure wavefunction population in each of the tweezers and to display an output pertaining to the wavefunction populations.Type: ApplicationFiled: July 17, 2024Publication date: January 23, 2025Applicant: Technion Research & Development Foundation LimitedInventor: Yoav SAGI
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Patent number: 12201386Abstract: Systems and methods for performing minimally invasive surgical procedures, especially for removal of tumors, and especially for brain tumors, using a robotically inserted therapeutic probe, which first detects tumorous tissue on a pre-planned path through the patient's tissue, before performing therapeutic procedures on the tissue, such as ablation. This pre-treatment detection procedure is thus able to avoid the destruction of healthy tissue. This also ensures that the therapeutic process indicated in a preoperative surgical plan is only performed on tumorous tissue, without sole reliance on preoperative image indications. This is important for neurosurgical operations performed on the brain, since preoperative images may not be accurate due to brain shift occurring during the procedure. Detection can be performed optically or ultrasonically, and treatment by laser or RF ablation. The probe insertion can be performed at 90° to the insertion axis of the device, thus minimizing passage through healthy tissue.Type: GrantFiled: September 6, 2018Date of Patent: January 21, 2025Assignee: Technion Research & Development Foundation LimitedInventors: Hadas Ziso, David Zarrouk, Moshe Shoham, Menashe Zaaroor
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Patent number: 12201628Abstract: A method for modulating an immune response by activating or inhibiting dopaminergic neurons in the Ventral Tegmental Area (VTA) is provided. Modulation is achieved by modulating the activity, the abundance or both of: a natural killer cell, a CD8 T-cell, a CD4 T-cell, a B-cell, a dendritic cell, a macrophage, a granulocyte, or their combination.Type: GrantFiled: September 19, 2022Date of Patent: January 21, 2025Assignees: TECHNION RESEARCH &DEVELOPMENT FOUNDATION LIMITED, HEALTH CORPORATION—RAMBAMInventors: Asya Rolls, Tamar Ben Shannan, Hilla Azulay-Debbie, Fahed Hakim, Maya Schiller, Shai Shen-Orr, Elina Starosvetsky