Patents Assigned to Technion Research & Development Foundation Ltd.
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Patent number: 12552882Abstract: Polymers including bifunctional mono- or poly-cyclic heterocyclic or heteroaromatic repeating units having disinfecting activity, compositions thereof, and methods for disinfecting surfaces utilizing the compositions. The method for disinfecting includes brushing, spraying, wiping, casting, dipping, or vapor coating, to the surface a disinfecting material to thereby render the surface antiseptic. The surface being disinfected by this method may be smooth, rough, tough, or soft, and may be selected from a cardboard, cloth, stainless steel or metallic surface, plastic, glass, wood, paper, surgical glove, or skin.Type: GrantFiled: October 27, 2021Date of Patent: February 17, 2026Assignee: Technion Research & Development Foundation Ltd.Inventor: Shady Farah
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Patent number: 12479739Abstract: The present invention provides a two-dimensional double perovskite nanomaterial represented by the formula Cs2ABX6 or L4[Cs2ABX6]n-1ABX8, wherein A is a metal ion selected from Ag(I), Au(I), and Cu(I); B is a metal ion selected from In(III), Bi(III), Sb(III), Fe(III), and Tl(III); X is a halogen; L is a ligand; and n represents the number of metal-halide octahedral layers present in said nanomaterial. The invention further provides a light emitting material and electronic-, optic-, or optoelectronic device comprising said nanomaterial; as well as methods for the preparation of said nanomaterial.Type: GrantFiled: October 22, 2021Date of Patent: November 25, 2025Assignee: Technion Research & Development Foundation Ltd.Inventors: Shai Levy, Sasha Khalfin, Yehonadav Bekenstein
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Patent number: 12441669Abstract: PCNHCP pincer metal complexes are useful as catalysts in various chemical reactions such as hydrogen isotope exchange (HIE) in C(sp3)-H and/or C(sp2)-H bond of an organic compound, e.g., a pharmaceutically active compound. The complexes are also useful in hydroboration of alkynes with excellent selectivity; and alkene isomerization with high stereo- and regioselectivity.Type: GrantFiled: August 22, 2021Date of Patent: October 14, 2025Assignee: Technion Research & Development Foundation Ltd.Inventors: Graham De Ruiter, Subhash Garhwal
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Patent number: 12329784Abstract: The ubiquitin ligase, RNF5, regulates the gut microbiota composition and influences the immune checkpoint response to tumors. RNF5 deficient animals exhibit significant inhibition of tumor development as well as an altered gut microbiota composition. Methods of treating cancer by administering to a subject one or more selected bacterial species and/or one or more prebiotics that promote the growth of one or more selected bacterial species are disclosed. Also disclosed are methods of treating cancer by administering to a subject one or more selected bacterial species and/or one or more prebiotics that promote the growth of one or more selected bacterial species in combination with one or more anti-cancer agents.Type: GrantFiled: January 30, 2023Date of Patent: June 17, 2025Assignees: Sanford Burnham Prebys Medical Discovery Institute, Technion Research & Development Foundation Ltd.Inventors: Yan Li, Scott Peterson, Linda Bradley, Roberto Tinoco, Ze'ev Ronai, Shiri Ashkenazi
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Publication number: 20250079018Abstract: A method including sensing local accelerations or changes in sensor position, including orientation and displacement, with a local acceleration sensor mounted on a chest or abdomen of a patient, and calculating energy of polyphasic motions, based on sensed information of the local acceleration sensor and classifying severity of cardiac decompensation by calculating an excessive energy index (EEi) that compares excessive energy that appears in the polyphasic motions to energy required for inspiration at a basic respiratory rate.Type: ApplicationFiled: November 14, 2024Publication date: March 6, 2025Applicants: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD., RAMBAM HEALTH CORPORATIONInventors: Amir Landesberg, Yakov Tsibulsky, Shmuel Rispler
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Patent number: 12042235Abstract: A system and method for ensuring safe and tolerable insertion of a needle into a subject's body according to a preplanned or continuously monitored sequence of insertion steps. The system comprises a gripping device for gripping the needle in order to perform robotic insertion steps, yet for releasing the grip between such insertion steps, until the next insertion step is initiated. Thereby, the robot has full control of the needle during insertion steps, but does not constrain the needle between insertions, such that movement of the subject can cause neither damage nor discomfort. The gripping and insertion steps may be coordinated to keep in synchronization with the subject's breathing cycles, such that the insertion steps may be performed in the same segment of each cycle of motion of the subject's chest. The gripper can either fully disconnect from the needle, or can partially disconnect but constrain motion within limits.Type: GrantFiled: May 10, 2023Date of Patent: July 23, 2024Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.Inventors: Daniel Glozman, Gonen Daskal, Moshe Shoham, Michael Arad, Yoav Pinsky
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Patent number: 11906498Abstract: Compositions comprising electrospun fibers and colorimetric detection encapsulated thereto are provided. Further, methods of use of said composition, including, but not limited to in-situ detection of molecules of interest, such as explosive compounds, are provided.Type: GrantFiled: October 19, 2020Date of Patent: February 20, 2024Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.Inventors: Eyal Zussman, Yuval Eshed, Reshef Gal-Oz
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Publication number: 20230333215Abstract: A device that may include a transmitter that is configured to transmit, per each sensing iteration, a radiation pulse; an array of pixels, each pixel comprises multiple subpixels, each subpixel comprises single photon avalanche diodes (SPADs) that are coupled to each other in parallel, and one or more quenching circuits, wherein each subpixel is configured to output a subpixel output signal indicative of a reflected radiation pulse sensed by one or more SPADs of the subpixel; wherein the reflected radiation pulse is reflected from an area of an object that was illuminated by the radiation pulse; and a processing circuit that is configured to: read, for each pixel, multiple subpixel output signals from the multiple subpixels of the pixel; receive, per each sensing iteration, transmission timing information indicative of a timing of transmission of the radiation pulse; and determine, per each sensing iteration and per each subpixel, a timing of a first detection of the reflected pulse detected by any of the SPAType: ApplicationFiled: April 12, 2021Publication date: October 19, 2023Applicant: Technion Research & Development Foundation Ltd.Inventors: Ayal Eshkoli, Yael Nemirovsky
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Patent number: 11781536Abstract: Disclosed is a closed drift, narrow channel Hall thruster configured to operate at powers <30 W. The thruster includes a thruster body and a neutralizing cathode. The thruster body includes a magnetic circuit including a magnetic source and two magnetic poles, a metallic, annular thruster channel formed by the magnetic poles with a downstream channel width smaller than about 3 mm and an upstream channel width greater than the downstream channel width, an anode positioned at the channel's entry, and a gas distributor configured to release a propellant gas into the thruster channel. The magnetic circuit is configured to generate a magnetic field in the thruster channel for trapping electrons therein. The channel walls (the magnetic poles) are under bias potential. The anode and the cathode are configured to generate a substantially axial electric field in the thruster channel.Type: GrantFiled: December 13, 2018Date of Patent: October 10, 2023Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.Inventors: Igal Kronhaus, Abraham Warshavsky
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Patent number: 11740225Abstract: The present invention provides methods for determining malignancy in a cyst by measuring viscosity of cyst fluid while under stain. The invention further provides devices, and computer program products for determining same.Type: GrantFiled: May 7, 2018Date of Patent: August 29, 2023Assignees: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD., RAMBAM MED-TECH LTD.Inventors: Iyad Khamaysi, Eyal Zussman
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Patent number: 11571446Abstract: The ubiquitin ligase, RNF5, regulates the gut microbiota composition and influences the immune checkpoint response to tumors. RNF5 deficient animals exhibit significant inhibition of tumor development as well as an altered gut microbiota composition. Methods of treating cancer by administering to a subject one or more selected bacterial species and/or one or more prebiotics that promote the growth of one or more selected bacterial species are disclosed. Also disclosed are methods of treating cancer by administering to a subject one or more selected bacterial species and/or one or more prebiotics that promote the growth of one or more selected bacterial species in combination with one or more anti-cancer agents.Type: GrantFiled: November 17, 2017Date of Patent: February 7, 2023Assignees: Sanford Bumham Prebys Medical Discovery Institute, Technion Research & Development Foundation Ltd.Inventors: Yan Li, Scott Peterson, Linda Bradley, Roberto Tinoco, Ze'ev Ronai, Shiri Ashkenazi
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Patent number: 11530690Abstract: A narrow channel Hall thruster comprising a thruster body with a magnetic circuit, an annular thruster channel having a channel width of less than 3 mm formed within the magnetic circuit, an annular anode, a cathode positioned externally to the thruster, and configured for electron emission, a power supply applying a positive potential to the anode, such that a plasma discharge can be generated in the annular thruster channel, and another power supply applying a negative potential to the cathode, relative to the thruster body and the anode. The second power supply reduces its negative voltage output to the cathode when the current supplied by the anode power supply exceeds a predetermined level, indicating that the discharge has reached a stable initiated condition. The reduction of the voltage output of the second power supply can be achieved either by self-regulation, or by use of a current limit circuit.Type: GrantFiled: February 13, 2020Date of Patent: December 20, 2022Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.Inventor: Igal Kronhaus
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Patent number: 11474954Abstract: A cache unit that is configured to retain: a plurality of cache blocks; a plurality of owner indicators, and a plurality of validity marks. For each cache block of the plurality of cache blocks exists a corresponding owner indicator in the plurality of owner indicators. An owner indicator corresponding to a cache block is capable of identifying an entity that caused the cache block to be fetched to the cache unit. For each cache block of the plurality of cache blocks exists a corresponding validity mark in the plurality of validity marks. A validity mark corresponding to the cache block indicates whether a validation process performed on the cache block upon fetching thereof was successful. The cache unit may be useful for secure execution.Type: GrantFiled: June 3, 2018Date of Patent: October 18, 2022Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.Inventors: Ofir Shwartz, Yitzhak Birk
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Patent number: 11450744Abstract: The present invention provides a conducting material comprising a carbon-based material selected from a diamond or an insulating diamond-like carbon, having a hydrogen-terminated surface and a layer of tungsten trioxide, rhenium trioxide, or chromium oxide coating said hydrogen-terminated surface. Such conducting materials are useful in the fabrication of electronic components, electrodes, sensors, diodes, field effect transistors, and field emission electron sources.Type: GrantFiled: September 2, 2018Date of Patent: September 20, 2022Assignee: Technion Research & Development Foundation Ltd.Inventors: Rafi Kalish, Moshe Tordjman
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Patent number: 11419503Abstract: An apparatus for optical detection of ultrasound includes one or more optical resonators (OR—200), one or more optical passive-demodulation interferometers (OPDI—22), and one or more respective electro-optical readout circuits (EORC—24). The one or more optical resonators (OR) are configured to modulate respective carrier frequencies of optical signals indicative of US waves impinging thereon. The one or more OPDI are implemented in one or more photonic integrated circuits (PIC), wherein each OPDI is configured to demodulate the optical signal output by the respective OR, so as to generate a respective intensity-modulated optical signal. Each OPDI includes an interferometer (32) having imbalanced arms (323, 325) that are recombined using an optical hybrid (34). The one or more respective EORC are each configured to measure the intensity demodulated optical signal produced by the respective OPDI, and to output a respective electrical signal.Type: GrantFiled: September 3, 2018Date of Patent: August 23, 2022Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.Inventors: Amir Rozental, Yoav Hazan
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Patent number: 11385001Abstract: New exemplary heat exchange configurations that incorporate internal or external surfaces equipped with perturbators, for changing the thermal behavior of the system, or for modulating the surface temperature distribution of the flow surfaces. This is achieved by applying an acoustic wave to the fluid flow in a heat exchange passage, and selecting the frequency of the acoustic exciting wave to be the same as the acoustic resonance frequency of the heat exchange passage itself. As the traveling waves interact with the boundaries confining the heat exchange passages, constructive interference of the incident and reflected waves give rise to a standing wave. Thus, the heat exchange passages act as a resonator, and by superimposing this standing wave on the separating and reattaching fluid flow, significant heat transfer improvement can be achieved. This is accomplished without the need to significantly increase the pressure required to achieve the desired through flow.Type: GrantFiled: May 5, 2020Date of Patent: July 12, 2022Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.Inventor: Beni Cukurel
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Patent number: 11346729Abstract: A pressure sensing device having a first sensing element, a second sensing element and a sensing circuit. The first and second sensing elements have one or more piezoresistive materials. The first sensing element has a first gradient along a longitudinal axis thereof having a first direction. The second sensing element has a second gradient along a longitudinal axis thereof having a second direction. The first direction of the first gradient is opposite to the second direction of the second gradient. The sensing circuit is (a) coupled to the first and second sensing elements and (b) arranged to sense at least one out of resistance and conductance of the first and second sensing elements to determine a magnitude and a location of a pressure applied on the first and second sensing elements along the longitudinal axes thereof.Type: GrantFiled: May 20, 2020Date of Patent: May 31, 2022Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.Inventors: Hossam Haick, Meital Segev-Bar, Gady Konvalina
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Patent number: 11299822Abstract: A method of producing a microtube is provided. The method comprising co-electrospinning two polymeric solutions through co-axial capillaries to thereby produce the microtube, wherein a first polymeric solution of the two polymeric solutions is for forming a shell of the microtube and a second polymeric solution of the two polymeric solutions is for forming a coat over an internal surface of the shell, the first polymeric solution is selected solidifying faster than the second polymeric solution and a solvent of the second polymeric solution is selected incapable of dissolving the first polymeric solution. Also provided are electrospun microtubes.Type: GrantFiled: March 1, 2017Date of Patent: April 12, 2022Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.Inventors: Eyal Zussman, Yael Dror, Wael Salalha, Ron Avrahami
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Patent number: 11105746Abstract: A system comprising: a high index dielectric configured to: a) create a bi-periodic interference pattern of two standing sinusoidal waves on illumination by two pairs of counter-propagating sinusoidal light beams at different incident angles, wherein the incident angles are selected in accordance with the index of refraction of the high index dielectric to i) to 5 determine the spatial frequency of each counter-propagating light beam pair, and ii) cause total internal reflection, and b) generate, from the bi-periodic interference pattern, an evanescent bi-periodic standing sinusoidal wave; a light source configured to illuminate the high index dielectric with the two pairs of counter-propagating sinusoidal light beams at the different incident angles and thereby illuminate a fluorescing object positioned at the surface of the high index dielectric with the generated evanescent bi-periodic standing sinusoidal wave; and one or more delay lines configured to independently modify the initial phase of each counterType: GrantFiled: July 18, 2017Date of Patent: August 31, 2021Assignee: Technion Research & Development Foundation Ltd.Inventors: Guy Bartal, Bergin Gjonaj, Yacob Yochai Blau, Doron Shterman
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Patent number: 10983059Abstract: An imaging apparatus (20) includes an interface (50) and a processor (30). The interface is configured to receive a sequence of images of an object (38) acquired at respective acquisition times, the object is labeled with fluorescent emitters. The images depict intensity fluctuations of emitters on an acquisition grid, and the intensity fluctuations being uncorrelated among the emitters and during an overall time over which the images in the sequence are acquired. The a processor is configured to calculate a temporal correlation function of the intensity fluctuations over the sequence of images, and to estimate locations of the emitters on a super-resolution grid having a higher resolution than the acquisition grid, by applying to the temporal correlation function a recovery process in which the locations on the super-resolution grid are assumed to be sparse or compressible in a predefined domain. The recovery process includes a sparse-recovery process or a regularized process.Type: GrantFiled: January 16, 2018Date of Patent: April 20, 2021Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.Inventors: Yonina Eldar, Mordechai Segev, Oren Solomon, Maor Mutzafi