Abstract: A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5? position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I: or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group consisting of alkyl, cycloalkyl and aryl; and all other variables and features are as described in the specification.

Abstract: This invention is directed to intramolecular crosslinked polymer chains, commonly known also as single-chain polymer nanoparticles (SCPNs), with high resistance to mechanochemical bond scission and to uses thereof in solution.

Abstract: A method for planning a current medical procedure to be performed on a body part of a current patient includes obtaining a current first representation of a surface of the body part of the current patient, and either obtaining a representation of a desired result surface for the current medical procedure or selecting parameters for the current medical procedure. The method further includes retrieving at least one best matching record from a database of records of previously performed medical procedures of previous patients, based on a similarity criterion. Each record includes: parameters of a previously performed procedure of the previously performed medical procedures, a first representation of the body part of the previous patient prior to performance of the previously performed procedure, and a second representation of a body part of the previous patient after the performance of the previously performed procedure.

Abstract: A system for converting an input oscillation having an input frequency into an output oscillation having an output frequency is disclosed. The system comprises: a controller configured for receiving the input oscillation and responsively generating a multi-component drive signal. A frequency of at least one component of the drive signal is other than two times the input frequency. In some embodiments, a frequency of another component of the drive signal equals about two times the output frequency. The system also comprises an oscillator for generating pump oscillations responsively to the drive signal and applying parametric excitation to the input oscillation at the pump oscillations.

Abstract: A system comprising: a camera configured to capture one or more images of a user's hand; and a computer configured to: receive the one or more captured images, apply a mapping function to the received one or more images, thereby yielding one or more coordinates associated with at least one feature of the user's hand, wherein the mapping function is derived from a set of labeled images that are produced by applying a machine learning algorithm to training data which comprises images of a trainer's hand, wherein the images are labeled with coordinates obtained from multiple magnetic sensors attached to the trainer's hand.

Abstract: A method and control system for controlling unmanned aerial vehicles to fly in coordinated manner, comprises arranging the unmanned aerial vehicles, each of which has an illumination element in a flying formation, and operating selected illumination elements to produce a display in which a pattern, shape or letters or words are detectable at a predetermined ground location.

Abstract: Single bulk unimorph piezoelectric elements, with interdigitated electrodes aligned obliquely relative to the direction perpendicular to the axis of the element, such that a torsional response is induced into the element. When such elements are used as a beam structure, with angularly oriented electrodes on both opposite surfaces of the beam, and with their orientations at mutually opposite angles, motion ranging from pure torsional rotation to pure bending can be obtained, depending on the comparative level and polarity of the voltages applied to each of the two electrode sets. If such elements are used as the spiral support arms of a central platform, a large displacement of the stage can be achieved. Due to the oblique orientation of the IDE's, the piezoelectric transduction induces torsional deformation in the spirals, and this torsion is converted by the spiral arms to a parallel out-of-plane platform motion.

Abstract: Provided are novel serum-free culture media which comprise basic fibroblast growth factor (bFGF), transforming growth factor beta-3 and ascorbic acid at a concentration of at least about 50 microgram/ml; ascorbic acid at a concentration range of about 400-600 microgram/ml, bFGF at a concentration range of about 50-200 ng/ml, xeno-free serum replacement and a lipid mixture; the IL6RIL6 chimera at a concentration range of about 50-200 picogram per milliliter (pg/ml); or leukemia inhibitory factor (LIF) at a concentration of at least 2000 units/ml; cell cultures comprising same with pluripotent stem cells such as human embryonic stem cells and induced pluripotent stem (iPS) cells, and methods of using same for expanding pluripotent stem cells in an undifferentiated state using two-dimensional or three-dimensional culture systems; and methods of expanding iPS cells in a suspension culture devoid of substrate adherence and cell encapsulation.

Abstract: Compositions comprising hollow mineral tubes comprising one or more essential oils (EOs) are disclosed. A process is provided for generating hollow mineral tube comprising one or more essential oils (EOs) and incorporating same in and/or on a substrate. Further disclosed are articles and methods, which are useful in inhibiting, reducing and/or retarding biofilm formation.

Abstract: An electro-optic system, the electro-optic system that may include an input port that is configured to receive a bandpass signal that conveys information; wherein the bandpass signal is a radio frequency (RF) signal; an optical carrier source that is configured to generate an optical carrier signal having an optical carrier frequency; at least one electrical bias circuit that is configured to generate at least one electrical bias signal; an electro-optic modulation circuit that is linear at the optical field; a manipulator that is configured to (a) receive the at least one electrical bias signal and the bandpass signal, (b) generate, based on the at least one electrical bias signal and the bandpass signal, at least one modulating signal; wherein the electro-optic modulation circuit is configured to modulate the optical carrier by the at least one modulating signal to provide an output optical signal that comprises at least one optical pilot tone and at least one optical sideband that conveys the information.

Abstract: A self cleaning inlet head for use on a shunt. The head has a tube with openings disposed in predetermined positions in its wall, and a cleaning element installed inside the tube. The cleaning element may comprise a central shaft with a number of bristles protruding therefrom, preferably in locations substantially identical to the positions of the openings in the wall of the tube. Mutual vibratory motion between the cleaning element and the tube causes at least some of the bristles to enter the openings, thereby keeping them clear, and preventing tissue growth into them. The vibratory motion may be generated by the action of an external field on a responsive part of the cleaning element, such as an external magnetic field operating on a magnetic or magnetized part of the cleaning element or the bristles. Alternatively, the external field may be an ultrasound field operating on the bristles.

Abstract: Methods and systems are provided for controlling a robot to navigate a perceptually aliased environment, the robot being configured to infer a first Gaussian mixture model (GMM) of a first pose of the robot, and to plan an optimal control action by: determining a second GMM of a simulated pose of the robot by simulating applying the first control action to the first GMM; determining from the second GMM a range of possible observations; calculating scene probabilities for associating each possible observation with each aliased scene of a set of aliased scenes; calculating from the scene probabilities an objective function to determine an estimated cost of the first control action; and comparing the estimated cost of the first control action with estimated costs calculated for one or more additional control actions, to determine an optimal control action.

Abstract: A flow bioreactor device for monitoring cellular dynamics may include a housing having one or a plurality of conduits to place one or a plurality of tissue samples inside each of said one or a plurality of conduits, wherein each of said one or a plurality of conduits has an inlet for introducing a flow of a liquid in a direction of flow through that conduit, wherein said one or a plurality of conduits are fluidically linked to an outlet for discharging the liquid, and wherein at least a portion of the housing is transparent so as to provide a line of sight for viewing or for an optical device along an elongated axis of any of said one or a plurality of conduits, the line of sight being substantially parallel to the direction of flow through that conduit.

Abstract: A compliant transmission system includes a rotatable wave generator and a sleeve fitted on the wave generator. The rotatable wave generator has an external surface including pattern extending both annularly and in a longitudinal direction. The sleeve is configured to be deformable and to be impressed on its outer surface with waves extending along the longitudinal direction during rotation of the pattern of the wave generator within the sleeve.

Abstract: Highly efficient digital domain sub-band based receivers and transmitters.

Abstract: Provided are methods and kits for determining predisposition of a subject to develop a kidney disease, by identifying in a sample of the subject at least one APOL1 polypeptide variant which is characterized by a higher trypanolytic activity on Trypanosoma brucei rhodesiense as compared to the trypanolytic activity of wild type APOL1 polypeptide as set forth in SEQ ID NO:1 on the Trypanosoma brucei rhodesiense under identical assay conditions; or at least one APOL1 nucleotide mutation in the APLO1 genomic sequence set forth in SEQ ID NO:3, wherein the at least one nucleotide mutation or polypeptide variant being in linkage disequilibrium (LD) with the S342G mutation in the APOL1 polypeptide set forth in SEQ ID NO:1, wherein presence of the APOL1 polypeptide variant indicates increased predisposition of the subject to develop the kidney disease.

Abstract: A method for creating brain-machine interface based on received and filtered brain signals from a subject, classifying the filtered signals to classes of brain states, detecting one brain state from the classified brain states and executing by a machine a command that corresponds to the detected state.

Abstract: Measurement of the three dimensional morphology of blood cells is performed using a model for simulating reflectance confocal images of the cells, providing the relation between cell morphology and the resulting interference patterns under confocal illumination. The simulation model uses the top and bottom membranes of the cell as the elements for generating the interference fringes, and takes into account the cell size, shape, angle of orientation and distance from the focal point of the confocal illumination beam. By comparing the simulated cell images to actual interference patterns obtained in confocal images obtained from the blood samples, the model can be used for providing three dimensional measurements of the individual cell morphology. This enables, for instance, in vitro measurement of the mean corpuscular volume of blood cells and diagnosis of hematological disorders which are associated with cell morphology deviations, such as thalassemia and sickle cell anemia.

Abstract: The present disclosure provides a delivery system comprising (i) a physiologically acceptable carrier and (ii) a proteolytic enzyme or effector thereof for use in a method for relaxing fibers within a subject's oral cavity. In some embodiments, the relaxation is for use in tooth manipulation (particularly repositioning). In some embodiments, the method involves the use of the proteolytic enzyme or effector thereof at a concentration effective to cause relaxation of fibers between the tooth's alveolar bone and gingiva while maintaining integrity of the fibers surrounding the tooth. Also disclosed herein are methods for fiber relaxation and/or repositioning of tooth making use of the proteolytic enzyme or effector thereof.

Abstract: The present invention provides a halo-de-carboxylation process for the preparation of organic chlorides, organic bromides and mixtures thereof, from their corresponding carboxylic acids, using a chlorinating agent selected from trichloroisocyanuric acid (TCCA), dichloroisocyanuric acid (DCCA), or combination thereof, and a brominating agent.