Patents Assigned to TECHNISCHE UNIVERSITÄT BERLIN
  • Patent number: 10738316
    Abstract: A method for obtaining at least one microbial secondary metabolite or a derivative thereof, the method includes the step of heterologous expression of at least one synthetase of the secondary metabolite in at least one filamentous fungus. Also disclosed is an expression cassette, a plasmid vector including the expression cassette, an expression host, cyclodepsipeptides and a chimeric cyclodepsipeptide synthetase.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: August 11, 2020
    Assignee: TECHNISCHE UNIVERSITÄT BERLIN
    Inventors: Simon Boecker, Dirk Storm, Vera Meyer, Lennart Richter, Sophia Zobel, Franziska Wanka, Roderich Suessmuth, Agnes Muehlenweg
  • Publication number: 20200231438
    Abstract: A process for the production of nanoparticles from a liquid mixture comprising at least one precursor and at least one solvent in a reactor with continuous through-flow comprises the steps of feeding at least one oxygen-containing gas inflow stream having a temperature into the at least one reactor, adding at least one fuel having a temperature to the oxygen-containing gas inflow stream, wherein the fuel and the oxygen-containing gas inflow stream form a homogeneous ignitable mixture having a temperature, wherein the temperature of the homogeneous ignitable mixture is above the autoignition temperature of the homogeneous ignitable mixture, introducing at least one precursor-solvent mixture into the homogeneous ignitable mixture; autoignition of the ignitable mixture of oxygen-containing gas and fuel after an ignition delay time to form a stabilized flame and reacting the precursor-solvent mixture in the stabilized flame to form nanoparticles from the metal salt precursor, removing the formed nanoparticles.
    Type: Application
    Filed: March 16, 2018
    Publication date: July 23, 2020
    Applicant: TECHNISCHE UNIVERSITÄT BERLIN
    Inventors: Sebastian SCHIMEK, Christian Oliver PASCHEREIT, Moritz SIEBER
  • Publication number: 20200199640
    Abstract: The proposed solution refers to a host cell for the heterologous synthesis of at least one omphalotin compound comprising polynucleotides encoding for polypeptides involved in the omphalotin biosynthesis, an expression vector comprising said polynucleotides and a process for obtaining at least one omphalotin compound from said host cell.
    Type: Application
    Filed: April 27, 2018
    Publication date: June 25, 2020
    Applicant: TECHNISCHE UNIVERSITÄT BERLIN
    Inventors: Sascha RAMM, Agnes MUEHLENWEG, Annette POCH-HASNEK, Eva MOESKER, Roderich SUESSMUTH, Bartlomiej KRAWCZYK
  • Publication number: 20200165214
    Abstract: A chemical compound is provided according to general formula (1):
    Type: Application
    Filed: December 21, 2017
    Publication date: May 28, 2020
    Applicant: TECHNISCHE UNIVERSITÄT BERLIN
    Inventors: Roderich SUESSMUTH, Dennis KERWAT, Stefan GRAETZ, Iraj BEHROZ, Leonard VON ECKARDSTEIN, Patrick Michael DURKIN, Marius MORKUNAS, John WESTON
  • Patent number: 10666239
    Abstract: The invention inter alia relates to a balanced frequency doubler comprising a first frequency doubler unit providing a first input port and a second input port, a second frequency doubler unit providing a third input port and a fourth input port, wherein the first, second, third and fourth input port are configured to receive a first, second, third and fourth input signal, respectively, wherein the first, second, third and fourth input signals all have the same first harmonic frequency, but are phase-shifted relative to one another, wherein a first current, the frequency spectrum of which comprises a second harmonic frequency that is double the first harmonic frequency, is driven through the first frequency doubler unit in response to the first and second input signal, wherein a second current, the frequency spectrum of which also comprises the second harmonic frequency, is driven through the second frequency doubler unit in response to the third and fourth input signals, and wherein a balanced output signal
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: May 26, 2020
    Assignee: Technische Universitaet Berlin
    Inventors: Georg Boeck, Soenke Felix Vehring
  • Patent number: 10639337
    Abstract: The present invention relates to a method for treating cancer in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of a Coxsackie B3 group virus or a modified form thereof, wherein the cells of the cancer express a heparan sulfate (HS) receptor on their surface and the virus binds to said HS receptor, enters and accumulates in the cancer cells, whereby at least some cancer cells undergo viral lysis.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: May 5, 2020
    Assignee: TECHNISCHE UNIVERSITÄT BERLIN
    Inventors: Henry Fechner, Ahmet Hazini, Vanessa Brueckner
  • Patent number: 10625249
    Abstract: A catalyst for the hydroformylation of at least one olefin, having a ligand fo the general formula (1) —R1, R2, R3 selected from the group including substituted and non-substituted alkyl, substituted and non-substituted aryl, substituted and non-substituted alkenyl, substituted and non-substituted alkinyl, substituted and non-substituted cycloalkyl, and substituted and non-substituted heterocycles, wherein R1, R2 and R3 can each be the same or different, L is selected from a group having a sandwich complex, an oxygen group, substituted and non-substituted alkylene or heterocycles, and substituted aryl or heteroaryl; and aryl and heteroaryl is each substituted with groups which contain at least two heteroatoms and are coupled to the Si via the at least two heteroatoms of the substituents, —n=1-10, preferably 1-5, particularly preferably 1, 2, or 3; and the ligand is coupled to the metal M from the group VIIIb of the periodic table of elements via the Si group.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: April 21, 2020
    Assignee: TECHNISCHE UNIVERSITÄT BERLIN
    Inventors: Matthias Driess, Reinhard Schomaecker, Burgert Blom, Marcel Schmidt
  • Publication number: 20200103213
    Abstract: An embodiment of the invention relates to a method for carrying out a time-resolved interferometric measurement comprising the steps of generating at least two coherent waves, overlapping said at least two coherent waves and producing an interference pattern, measuring the interference pattern for a given exposure time, thereby forming measured interference values, and analyzing the measured interference values and extracting amplitude and/or phase information from the measured interference values. In at least one time segment, hereinafter referred to as disturbed time segment, of the exposure time, the interference pattern is intentionally disturbed or destroyed such that the corresponding measured interference values describe a disturbed or destroyed interference pattern.
    Type: Application
    Filed: February 27, 2018
    Publication date: April 2, 2020
    Applicant: Technische Universitaet Berlin
    Inventors: Michael LEHMANN, Tore NIERMANN, Tolga WAGNER
  • Patent number: 10598859
    Abstract: An optoelectronic component including an optical waveguide integrated into a plane of the component. The optical waveguide configured to guide optical radiation in the plane. The component including a coupling element connected to the waveguide and coupling optical radiation into the waveguide along the main coupling path. The degree of coupling efficiency of the coupling element is less than one in respect to the main coupling path. The coupling element outputs optical loss radiation along a secondary coupling path. The optical loss radiation is proportional to the radiation transferred along the main coupling path. The optoelectronic component includes a detector connected to the coupling element that registers the optical loss radiation and produces a detector signal. The optoelectronic component includes a control unit configured to influence at least one operating variable of the optoelectronic component based on the detector signal.
    Type: Grant
    Filed: May 3, 2016
    Date of Patent: March 24, 2020
    Assignee: TECHNISCHE UNIVERSITÄT BERLIN
    Inventors: Stefan Meister, Hanjo Rhee, Christoph Theiss, Aws Al-Saadi
  • Publication number: 20200091900
    Abstract: The invention inter alia relates to a balanced frequency doubler comprising a first frequency doubler unit providing a first input port and a second input port, a second frequency doubler unit providing a third input port and a fourth input port, wherein the first, second, third and fourth input port are configured to receive a first, second, third and fourth input signal, respectively, wherein the first, second, third and fourth input signals all have the same first harmonic frequency, but are phase-shifted relative to one another, wherein a first current, the frequency spectrum of which comprises a second harmonic frequency that is double the first harmonic frequency, is driven through the first frequency doubler unit in response to the first and second input signal, wherein a second current, the frequency spectrum of which also comprises the second harmonic frequency, is driven through the second frequency doubler unit in response to the third and fourth input signals, and wherein a balanced output signal
    Type: Application
    Filed: September 14, 2018
    Publication date: March 19, 2020
    Applicant: Technische Universitaet Berlin
    Inventors: Georg Boeck, Soenke Felix Vehring
  • Patent number: 10526716
    Abstract: The invention relates to a method for producing a metal chalcogenide thin film electrode, comprising the steps: (a) contacting a metal or metal oxide with an elementary halogen in a non-aqueous solvent, producing a metal halide compound in the solution, (b) applying a negative electric voltage to an electrically conducting or semiconducting substrate which is in contact with the solution from step (a), and (c) during and/or after step (b) contacting the substrate with an elementary chalcogen forming a metal chalcogenide layer on the substrate. The invention also relates to a metal chalcogenide thin film electrode which can be produced by the method and its use as an anode for releasing oxygen during (photo)electrochemical water splitting.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: January 7, 2020
    Assignee: TECHNISCHE UNIVERSITAET BERLIN
    Inventors: Michael Lublow, Anna Fischer, Matthias Driess, Thomas Schedel-Niedrig, Marcel-Philip Luecke
  • Publication number: 20190383297
    Abstract: The invention relates to a method for determining an indicator for a prediction of an instability in a compressor, which is designed as an axial or radial compressor, having the following steps: operating a compressor designed as an axial or radial compressor in operating states, which differ by different values of a characteristic parameter for a flow mass flux of the compressor, wherein the operating states are run through at decreasing flow mass fluxes; determining the values of the characteristic value for the flow mass flux for the operating states; detecting time-resolved pressure measurement values when running through the operating states by means of a pressure sensor, which is arranged in a housing of the compressor, upstream adjacent to an entrance plane of a rotor stage determining the skew for the operating states and determining an indicator for an instability of the compressor, if an algebraic sign change of the curve rise is determined for a curve profile of the skew over the characteristic par
    Type: Application
    Filed: March 1, 2018
    Publication date: December 19, 2019
    Applicant: TECHNISCHE UNIVERSITÄT BERLIN
    Inventors: Mario ECK, Dieter PEITSCH
  • Patent number: 10501606
    Abstract: The invention relates to a method for the preparation of modified cellulose fibers for artificial clarification of active haze substances from liquids. In addition, the invention relates to a modified cellulose fiber obtained by the method according to the invention for artificial clarification of active haze substances from a liquid, and to auxiliary filtering means containing one or more of the modified cellulose fibers.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: December 10, 2019
    Assignee: Technische Universität Berlin
    Inventors: Thomas Kunz, Niklas Ole Brandt, Frank-Jürgen Methner
  • Patent number: 10486113
    Abstract: A fluid distribution device for a gas-liquid contactor the device having a first side, a second side and a plurality of through-holes extending from the first side to the second side, through which holes a first fluid can flow. The fluid distribution device further having an interior, which is delimited by the first side and the second side and which is sealed in a fluid-tight manner in relation to the through-holes, a plurality of openings, which connect the interior to the second side, and a fluid connection, through which a second fluid can be introduced into or evacuated from the interior. A gas-liquid contactor having a fluid distribution device of this type and to a method for adding a gas to a liquid is also disclosed.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: November 26, 2019
    Assignee: TECHNISCHE UNIVERSITÄT BERLIN
    Inventors: Marina Sabelfeld, Sven-Uwe Geissen
  • Patent number: 10475238
    Abstract: Computer implemented method for rendering an image of a three-dimensional scene on an image plane by encoding at least a luminosity in the image plane by a luminosity function. The value of the luminosity can be computed at substantially each point of the image plane by using a set of stored input data describing the scene. The method includes constructing the luminosity function as equivalent to a first linear combination involving the functions of a first set of functions, and computing at least the value of the coefficients of the first linear combination, by solving a first linear system, obtained by using at least the functions of the first linear combination, at least a subset of the first subset of the image plane, and the luminosity at the points of said subset. The method further includes storing the value of the coefficients of the first linear combination and at least the information needed to associate each coefficient to the function multiplying said coefficient in the first linear combination.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: November 12, 2019
    Assignees: UNIVERSITY OF TORONTO, Technische Universität Berlin
    Inventors: Christian Lessig, Eugene Fiume
  • Publication number: 20190238379
    Abstract: Systems and methods for transmitting data using various Modulation on Zeros schemes are described. In many embodiments, a communication system is utilized that includes a transmitter having a modulator that modulates a plurality of information bits to encode the bits in the zeros of the z-transform of a discrete-time baseband signal. In addition, the communication system includes a receiver having a decoder configured to decode a plurality of bits of information from the samples of a received signal by: determining a plurality of zeros of a z-transform of a received discrete-time baseband signal based upon samples from a received continuous-time signal, identifying zeros that encode the plurality of information bits, and outputting a plurality of decoded information bits based upon the identified zeros.
    Type: Application
    Filed: January 28, 2019
    Publication date: August 1, 2019
    Applicants: California Institute of Technology, Technische Universität Berlin
    Inventors: Philipp Walk, Babak Hassibi, Peter Jung
  • Patent number: 10355705
    Abstract: It is provided a signal processing system, comprising at least a first, a second and a third digital-to-analog converter (DAC); a processing unit configured for splitting a sampled signal into a first and a second signal corresponding to different frequency portions of the sampled signal, transmitting the first signal to the first DAC, splitting the second signal into a first and a second subsignal and transmitting the first subsignal to the second DAC and the second subsignal to the third DAC, the first subsignal corresponding to the real part of the second signal and the second subsignal corresponding to the imaginary part of the second signal; an IQ mixer configured for mixing an analog output signal of the second DAC and an analog output signal of the third DAC and a combiner for combining an analog output signal of the first DAC and an output signal of the IQ mixer.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: July 16, 2019
    Assignees: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V., TECHNISCHE UNIVERSITÄT BERLIN
    Inventors: Christian Schmidt, Christoph Kottke, Volker Jungnickel, Jonas Hilt
  • Patent number: 10308595
    Abstract: Antibiotically active compounds characterized by general formula (I), wherein X1, BB, BC, BD, BE and X2 are building blocks with D1, D2, D3, D4 or D5 being linkers which include carbon, sulphur, nitrogen, phosphor and/or oxygen atoms and which are covalently connecting the moities BA and BB, BB and BC, BC and BD, BD and BE and BE and BF, respectively, and wherein in particular the building block BC comprises an amino acid derivative. The compounds for use in a method of treatment of diseases, in particular for use in a method of treatment of bacterial infections are also disclosed.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: June 4, 2019
    Assignee: TECHNISCHE UNIVERSITÄT BERLIN
    Inventors: Roderich Suessmuth, Julian Kretz, Vivien Schubert, Alexander Pesic, Manuela Huegelland, Monique Royer, Stephane Cociancich, Philippe Rott, Dennis Kerwat, Stefan Graetz
  • Patent number: 10299940
    Abstract: A method for producing a three-dimensional, multi-cell object, in which polymerized structures are produced in layers by the irradiation of light radiation. To this end, use is made of photopolymerizable liquids which at least partly comprise biological cells. The invention also relates to a device for carrying out such a method and to the use of this device for producing an artificial organ.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: May 28, 2019
    Assignee: TECHNISCHE UNIVERSITÄT BERLIN
    Inventor: Lutz Kloke
  • Publication number: 20190146151
    Abstract: The invention relates to an optoelectronic component (100) comprising a chip (110) comprising a substrate (12) and at least one optical waveguide (20) integrated in the chip (110). In one variant of the invention it is provided that an electro-optical component (30) is monolithically integrated in one or a plurality of semiconductor layers of the chip (110) arranged on the substrate top side (12a) of the substrate (12), or on the substrate top side (12a) of the substrate (12) and at least one electrical connection of the monolithically integrated electro-optical component (30) is connected by means of a connection line (41) to a conductor track connection (43) situated below the substrate rear side (12b), wherein the connection line (41) extends through a through hole (42) in the substrate (12) from the electro-optical component (30) to the conductor track connection (43) situated below the substrate rear side (12b).
    Type: Application
    Filed: September 28, 2015
    Publication date: May 16, 2019
    Applicant: TECHNISCHE UNIVERSITÄT BERLIN
    Inventors: Stefan MEISTER, Hanjo RHEE, Christoph THEISS, Sebastian KUPIJAI