Patents Assigned to Technische Universitaet Braunschweig
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Patent number: 11967666Abstract: A semiconductor device for emitting electromagnetic radiation, and to a method of producing the same, which can be used as a semiconductor-based, structured light source. The semiconductor device comprises a layer stack structure composed of an n-doped layer, an active layer and a p-doped layer, as well as a connection structure comprising conductor layers and at least one insulator layer, the conductor layers being arranged, parallel to and spaced apart from one another, along a first direction that is parallel to the active layer of the layer stack structure, and at least one insulator layer being arranged between at least two conductor layers, one or more conductor layers being electrically connected to the p-doped layer of the layer stack structure.Type: GrantFiled: March 7, 2018Date of Patent: April 23, 2024Assignee: Technische Universität Braunschweig Korperschaft Des Offentlichen RechtsInventors: Sönke Fündling, Frederik Steib, Andreas Waag
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Patent number: 11789250Abstract: An optical detection device having a light detection device and a light emission device is arranged such that the light detection side of the light detection device is optically coupled to a light emission side of a light source array of the light emission device via an examination region. The light detection device generates an electrical signal n response to light that reaches the light detection side. The light source array includes a plurality of separately actuatable electric light sources which are arranged in a matrix structure or two dimensional geometric arrangement. The object to be examined can be arranged in a desired fashion, and the light emitted by the light sources radiates via the examination region on the light detection side of the light detection device. An optical reduction is system is arranged in the beam path from the light emission side to the examination region and is configured to demagnify the light pattern which is emitted by the light sources.Type: GrantFiled: November 3, 2020Date of Patent: October 17, 2023Assignee: TECHNISCHE UNIVERSITÄT BRAUNSCHWEIGInventors: Andreas Waag, Daria Bezshlyakh, Hendrik Spende, Jan Gülink
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Publication number: 20230183375Abstract: The present invention relates to human tissue kallikrein 7 (KLK7) selective inhibitor compounds, combinations including these compounds, process to obtain the referred compounds, and methods of using the same. The present invention belongs to the field of chemistry, pharmacology and medicine.Type: ApplicationFiled: May 14, 2021Publication date: June 15, 2023Applicants: Fundação Universidade Federal do ABC - UFABC, Technische Universität BraunschweigInventors: Luciano PUZER, Ana Flávia SANTARINE LAUREANO, Daniele RIBEIRO DE ARAÚJO, Michael HUST
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Patent number: 11407819Abstract: The present disclosure provides methods and composition including vaccines, monoclonal antibodies, polyclonal antibodies, chimeric molecule of an extracellular fibrinogen binding protein (Efb) and targeted agent delivery pharmaceutical composition comprising at least a portion of a modified N-terminus region, at least a portion of a modified C-terminus region, or both, wherein the modified extracellular fibrinogen binding protein results in inhibiting the fibrinogen binding, C3 binding, or both or administering to a subject a pharmacologically effective amount of a vaccine in a pharmaceutically acceptable excipient, comprising a modified extracellular fibrinogen binding protein comprising at least a portion of a modified N-terminus region, at least a portion of a modified C-terminus region, or both, wherein the modified extracellular fibrinogen binding protein results in not shielding the staphylococcus bacterium from recognition by a phagocytic receptor.Type: GrantFiled: May 20, 2020Date of Patent: August 9, 2022Assignees: The Texas A&M University System, Technische Universität Braunschweig, Università Degli Studi Di PaviaInventors: Ya-Ping Ko, Magnus Hook, Srishtee Arora, Livia Visai, Federico Bertoglio, Michael Hust, Doris Meier
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Publication number: 20220109086Abstract: A semiconductor device for emitting electromagnetic radiation, and to a method of producing the same, which can be used as a semiconductor-based, structured light source. The semiconductor device comprises a layer stack structure composed of an n-doped layer, an active layer and a p-doped layer, as well as a connection structure comprising conductor layers and at least one insulator layer, the conductor layers being arranged, parallel to and spaced apart from one another, along a first direction that is parallel to the active layer of the layer stack structure, and at least one insulator layer being arranged between at least two conductor layers, one or more conductor layers being electrically connected to the p-doped layer of the layer stack structure.Type: ApplicationFiled: March 7, 2018Publication date: April 7, 2022Applicants: Photonik Inkubator GmbH, Technische Universität Braunschweig Körperschaft Des Öffentlichen RechtsInventors: Sönke Fündling, Frederik Steib, Andreas Waag
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Patent number: 11160831Abstract: The invention provides a fusion protein for use in the treatment of HvG disease in a patient having received a transplant, for use in suppressing the host's immune response directed against the transplant. The fusion protein is adapted for use in suppressing the immune rejection of a transplant which contains or expresses HLA-A*02 or SLA-01*0401 in a recipient patient who is negative for HLA-A*02 or SLA-01*0401, i.e. the patient prior to transplantation does not express HLA-A*02 or SLA-01*0401. The fusion protein is a chimeric antigen receptor (CAR), which upon expression in regulatory T-cells (Treg) causes a specific suppressor activity of the regulatory T-cells in the presence of HLA-A*02 or SLA-01*0401.Type: GrantFiled: June 22, 2017Date of Patent: November 2, 2021Assignees: Medizinische Hochschule Hannover, Technische Universität BraunschweigInventors: Elmar Jäckel, Fatih Noyan, Michael Hust
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Publication number: 20210030853Abstract: The present invention relates to combinations of tick-derived antigens for use as a tick vaccine.Type: ApplicationFiled: April 17, 2019Publication date: February 4, 2021Applicant: Technische Universität BraunschweigInventors: Michael HUST, Stefan DÜBEL
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Patent number: 10879477Abstract: The present invention relates to a cyclic amine surface modifier. In addition the present invention also relates to organic electronic devices comprising such cyclic amine surface modifier.Type: GrantFiled: February 16, 2015Date of Patent: December 29, 2020Assignees: MERCK PATENT GMBH, INNOVATIONLAB GMBH, TECHNISCHE UNIVERSITAET BRAUNSCHWEIG, MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.Inventors: Malte Jesper, Manuel Hamburger, Janusz Schinke, Milan Alt, Klaus Muellen
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Patent number: 10629815Abstract: The invention relates to new conjugated semiconducting polymers containing thermally cleavable side groups. The thermally cleavable side groups are selected from among carbonate groups and carbamate groups. By thermally cleaving side groups, the solubility or the polymers can be reduced in a targeted manner. The polymers are used as semiconductors in organic electronic (OE) devices, especially in organic photovoltaic (OPV) devices, organic photodetectors (OPDs), organic light emitting diodes (OLEDs), and organic field effect transistors (OFETs).Type: GrantFiled: February 10, 2015Date of Patent: April 21, 2020Assignees: INNOVATIONLAB GMBH, KARLSRUHER INSTITUT FUER TECHNOLOGIE, TECHNISCHE UNIVERSITAET BRAUNSCHWEIG, MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.Inventors: Marius Kuhn, Torben Adermann, Manuel Hamburger, Klaus Muellen, Janusz Schinke, Alexander Colsmann, Stefan Hoefle, Ulrich Lemmer
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Patent number: 10340813Abstract: Multi-phase electronic power converter (50) for outputting multi-phase alternating current, wherein for every phase the current converter (50) comprises a power output (52) controlled via at least two semiconductor switches (51) connected in a half-bridge circuit, wherein the electronic power converter (50) has a control device (53) which is configured for processing a target value signal of the control device (53) supplied as an input signal, each in the form of a bit stream (1, 2, 3, 30, 31, 32) of one or more bits for every phase, characterized in that the control device (53) is configured by means of space-vector modulation to generate actuation signals (P1, P2, P3) of the semiconductor switches (51) in relation to the bit streams (1, 2, 3, 30, 31, 32) supplied as an input signal.Type: GrantFiled: June 18, 2015Date of Patent: July 2, 2019Assignee: TECHNISCHE UNIVERSITÄT BRAUNSCHWEIGInventors: Walter Schumacher, Michael Homann
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Indole compounds having antiprotozoal activity and its use as well as methods for producing the same
Patent number: 10287271Abstract: In a first aspect, the present invention relates to new compounds as depicted in formula (I). In particular, compounds according to the present invention are bisindolylcyclobuten-dione-based structures having antiprotozoal activity. In a further aspect, pharmaceutical compositions containing the same are provided as well as the use of the compounds and pharmaceutical compositions for the prophylaxis and treatment of parasite based diseases including malaria. Finally, methods for the treatment of parasite diseases including malaria are provided.Type: GrantFiled: July 10, 2015Date of Patent: May 14, 2019Assignees: TECHNISCHE UNIVERSITAET BRAUNSCHWEIG, YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.Inventors: Conrad Kunick, Hoang Lande, Johann Gruenefeld, Ron Dzikowski, Abed Nasereddin -
Patent number: 10201054Abstract: The invention relates to a light emitting device comprising a light source array which comprises a plurality of separately electrically controllable electric light sources which are arranged in a matrix structure or any other defined geometrical arrangement. Advantageously, the pixel pitch of the light source array is less than (500) nanometer. The invention further relates to an optical detection device comprising a light detection device, which is arranged for producing an electrical signal in response to light reaching a light detection side of the light detection device, and to a method for operating such an optical detection device. The invention further relates to a computer program with program coding means arranged for performing such a method.Type: GrantFiled: July 6, 2016Date of Patent: February 5, 2019Assignees: TECHNISCHE UNIVERSITAET BRAUNSCHWEIG, UNIVERSITAT DE BARCELONA CENTRE DE PATENTS DE LA UBInventors: Andreas Waag, Juan Daniel Prades Garcia, Martin Hoffmann
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Patent number: 10164191Abstract: The present invention relates to a methoxyaryl surface modifier. In addition the present invention also relates to organic electronic devices comprising such methoxyaryl surface modifier.Type: GrantFiled: February 16, 2015Date of Patent: December 25, 2018Assignees: Merck Patent GmbH, InnovationLab GmbH, Technische Universitaet Braunschweig, Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V.Inventors: Malte Jesper, Manuel Hamburger, Janusz Schinke, Milan Alt, Klaus Muellen
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Patent number: 10099195Abstract: Positioning structures in at least one indentation present on a or in a support, wherein said indentation is an indentation having a diameter in the nanometer range, makes it possible to position the structure in the indentation substantially centrally with defined orientation. A support having at least one indentation, wherein the indentation has a size in the nanometer range, includes a predetermined structure which is arranged substantially centrally within said indentation and which optionally has a functional unit diametrically opposite to the side pointing to the bottom surface. The arrangement is especially suitable for single molecule analysis and, here especially, for single molecule sequencing and other high-throughput methods.Type: GrantFiled: April 16, 2015Date of Patent: October 16, 2018Assignee: Technische Universität BraunschweigInventors: Philip Tinnefeld, Guillermo Acuna, Enrico Pibiri
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Publication number: 20170331043Abstract: The invention relates to new conjugated semiconducting polymers containing thermally cleavable side groups. The thermally cleavable side groups are selected from among carbonate groups and carbamate groups, By thermally cleaving side groups, the solubility or the polymers can he reduced in a targeted manner. The polymers are used as semiconductors in organic electronic (OE) devices, especially in organic photovoltaic (OPV) devices, organic photodetectors (OPDs), organic light emitling diodes (OLEDs), and organic field effect transistors (OFETs).Type: ApplicationFiled: February 10, 2015Publication date: November 16, 2017Applicants: INNOVATIONLAB GMBH, KARLSRUHER INSTITUT FUER TECHNOLOGIE, TECHNISCHE UNIVERSITAET BRAUNSCHWEIG, MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENS CHAFTEN E.V.Inventors: Marius Kuhn, Torben Adermann, Manuel Hamburger, Klaus Muellen, Janusz Schinke, Alexander Colsmann, Stefan Hoefle, Ulrich Lemmer
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Publication number: 20170179844Abstract: Multi-phase electronic power converter (50) for outputting multi-phase alternating current, wherein for every phase the current converter (50) comprises a power output (52) controlled via at least two semiconductor switches (51) connected in a half-bridge circuit, wherein the electronic power converter (50) has a control device (53) which is configured for processing a target value signal of the control device (53) supplied as an input signal, each in the form of a bit stream (1, 2, 3, 30, 31, 32) of one or more bits for every phase, characterised in that the control device (53) is configured by means of space- vector modulation to generate actuation signals (P1, P2, P3) of the semiconductor switches (51) in relation to the bit streams (1, 2, 3, 30, 31, 32) supplied as an input signal.Type: ApplicationFiled: June 18, 2015Publication date: June 22, 2017Applicant: TECHNISCHE UNIVERSITAET BRAUNSCHWEIGInventors: Walter Schumacher, Michael Homann
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Publication number: 20170062722Abstract: The present invention relates to a methoxyaryl surface modifier. In addition the present invention also relates to organic electronic devices comprising such methoxyaryl surface modifier.Type: ApplicationFiled: February 16, 2015Publication date: March 2, 2017Applicants: Merck Patent GmbH, InnovationLab GmbH, Technische Universitaet Braunschweig, Max-Planck-Gesellschaft Zur Foerderung Der Wissens chaften E.V.Inventors: Malte JESPER, Manuel HAMBURGER, Janusz SCHINKE, Milan ALT, Klaus MUELLEN
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Publication number: 20170062744Abstract: The present invention relates to a cyclic amine surface modifier. In addition the present invention also relates to organic electronic devices comprising such cyclic amine surface modifier.Type: ApplicationFiled: February 16, 2015Publication date: March 2, 2017Applicants: MERCK PATENT GMBH, INNOVATIONLAB GMBH, TECHNISCHE UNIVERSITAET BRAUNSCHWEIG, MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENS CHAFTEN E.V.Inventors: Malte JESPER, Manuel HAMBURGER, Janusz SCHINKE, Milan ALT, Klaus MUELLEN
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Patent number: 9476832Abstract: The present invention relates to an apparatus for the optical analysis of a sample, also referred to as microscope, which is configured for an optical analysis process having high resolution for the detection of fluorescent molecules. The apparatus and the process applied when using the apparatus are configured for excitation light generated by an excitation light source to be directed onto a sample and the light emitted by the probe is detected. The apparatus and the process are characterized in that the excitation light is synchronized with the detection. The apparatus is characterized in that it has a polarization device which is configured to modulate the polarization of the excitation light with a modulation signal, wherein the modulation signal has or consists of at least one frequency, in particular a pre-determined frequency or several pre-determined superimposed frequencies, or the modulation signal consists of a sequence of signals that has no repetition.Type: GrantFiled: December 5, 2012Date of Patent: October 25, 2016Assignee: TECHNISCHE UNIVERSITAET BRAUNSCHWEIGInventors: Peter J. Walla, Nour Hafi
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Patent number: 9268618Abstract: A method for operating a multiprocessor computer system which has at least two microprocessors, resources which are jointly used by the microprocessors, programs executed on the computer system, and at least one resource manager. The resource manager manages resources which are assigned to said manager and can be adjusted at least in terms of their time response. The resource manager receives and processes reservation requests for reserving desired resources, which reservation requests are transmitted by programs. The reservation requests describe at least the type, scope and time response of the desired resources. The resource manager allocates the respectively desired resources to the requesting program if said resources are available. The resource manager adjusts the time response of the allocated resources according to the time response requested with the reservation request.Type: GrantFiled: May 28, 2013Date of Patent: February 23, 2016Assignee: Technische Universitaet Braunschweig Carolo-WilhelminaInventors: Rolf Ernst, Jonas Diemer