Abstract: The present invention relates to a novel method for stabilizing nucleic acid nanostructures by curing with ultraviolet light, particularly by crosslinking pyrimidine nucleotides.

Abstract: This disclosure relates to a method for the additive manufacturing of an object, including supplying a strand-shaped starting material to a friction arrangement, and accelerating the starting material along an output direction through the friction arrangement, to apply the starting material onto a construction platform and/or onto already manufactured areas of the object for manufacturing the object, wherein the starting material is at least partially liquefied and/or at least partially plasticized and/or at least partially broken down into particles by the friction arrangement. This disclosure also relates to a manufacturing device to perform such methods.

Abstract: A manufacturing device for manufacturing an object in layers includes at least one transfer platform with a transfer platform surface, at least one application unit configured to apply at least one treatment layer and at least one material layer which together form a pre-material layer of the object, to the transfer platform surface, wherein the pre-material layer extends at least in a first direction (x) and/or in a second direction (y), and a construction platform configured to receive at least the at least one material layer of the pre-material layer from the transfer platform so that the object is manufactured in layers on the construction platform in a third direction (z).

Abstract: An apparatus for promoting a mass transfer reaction having a flow distributor and a drive unit. The flow distributor has a top end surface, a bottom end surface and a peripheral surface that are axisymmetric with respect to a rotation axis. The flow distributor is configured to submerge in a fluid medium and to generate a flow of the fluid medium through at least one of the top end surface and the bottom end surface and through the peripheral surface by rotating around the rotation axis. The drive unit is configured to move the flow distributor perpendicular to the rotation axis.

Abstract: A wafer includes a substrate and at least one intermediate layer formed on a surface of the substrate. The at least one intermediate layer covers the surface of the substrate at least partially. An outer surface of the at least one intermediate layer is directed away from the surface of the substrate. The wafer further includes nanostructures grown on the outer surface of the at least one intermediate layer. The at least one intermediate layer is formed in such a way that positions of growth of the nanostructures are predetermined on the outer surface of the at least one intermediate layer. At least one nanostructure material of the nanostructures is assembled at the positions of growth of the nanostructures.

Abstract: A method for aggregating a cluster of particles having a target cluster constitution in a channel comprising a retention section comprises the steps of establishing a fluid stream comprising a fluid carrier medium and particles of at least one type through said channel; controlling a supply of said particles of at least one type into the fluid stream; operating a retention mechanism to aggregate at least part of said particles in an aggregation region within said retention section, to thereby form said cluster of particles; monitoring, while operating said retention mechanism, the particles in at least part of said channel for obtaining a monitoring signal associated with the cluster and/or with the particles moving in the fluid stream; determining a current cluster constitution from the monitoring signal; comparing said current cluster constitution with said target cluster constitution; and controlling at least one of said particle retention mechanism and said supply of said particles of at least one type, s

Abstract: The invention relates to compounds which are suitable for treating bacterial diseases and to pharmaceutical compositions containing such compounds. The invention further relates to a kit of parts comprising such compounds and to the use of such compounds as disinfectants.

Abstract: The invention concerns a method of operating a fuel cell system (1) in fuel cell mode, the fuel cell system (1) comprising at least one fuel cell (2) comprising an anode (2a), a cathode (2b) and an electrolyte (2c) provided between the anode (2a) and the cathode (2b), the fuel cell (2) being arranged for an internal reformation of hydrocarbon compounds inside the anode (2a), an anode exhaust conduit (4) connecting the anode outlet (2d) and a fuel conduit (6) and comprising a methanation unit (3a), a water-gas shift reactor (3b), and a water vapor condenser or water removal unit (12), the anode exhaust conduit (4) or the fuel conduit (6) comprising a carbon dioxide separation unit (11), and the fuel conduit (6) connecting a fuel cell system inlet (7) and an anode inlet (2e), the method comprising the steps of a) feeding feed gas into the fuel conduit (6) via the fuel cell system inlet (7), the feed gas comprising hydrocarbon compounds, b) controlling the methanation unit (3a) to produce methane and controlling

Abstract: The present invention relates to a cluster of differentiation 98 heavy chain (CD98hc)-specific binding protein, wherein the CD98hc-specific binding protein is a lipocalin 2 (Lcn2)-derived binding protein and binds to CD98hc with a KD of 200 nM or lower.

Abstract: A method for aligning the positions and orientations of a real object and a virtual object in real space, the virtual object corresponding to a virtual replica of the real object, the method comprising visualizing at least one alignment feature superimposed on or replacing a representation of the virtual object in a field of view containing the real object, wherein the alignment feature is indicative of a position and orientation of the virtual object in real space, and wherein the at least one alignment feature complements a shape and/or surface pattern of the real object, such that the alignment feature and the real object form a composite object with complementing patterns and/or shapes in the field of view, when the real object and the virtual object are aligned.

Abstract: Disclosed herein is a sensor chip for parallelized magnetic sensing of a plurality of samples, a system for parallelized magnetic sensing of a plurality of samples and a method for probing a plurality of samples using optically addressable solid-state spin systems. The sensor chip comprises an optically transparent substrate comprising a plurality of optically addressable solid-state spin systems arranged in a plurality of sensing regions in a surface layer below a top surface of the substrate. The sensor chip further comprises a plurality of sample sites, wherein each sample site is arranged above a respective sensing region. The sensor chip has a light guiding system configured to provide an optical path through the substrate connecting each of the sensing regions.

Abstract: Provided herein is a method for treating a lymphoma in a subject in need thereof, comprising administering to the subject an effective amount of at least one PD-1 pathway agonist.

Abstract: The present disclosure relates to imaging and endoradiotherapy of diseases involving chemokine receptor 4 (CXCR4). Provided are compounds which bind or inhibit hCXCR4 and mCXCR4 and furthermore carry at least one moiety which is amenable to labeling. Provided are also medical uses of such compounds.

Abstract: The present invention relates to a method for generating and/or obtaining specific binding moieties against intrinsically disordered proteins (IDPs) and/or intrinsically disordered protein domains which tend to be immunologically inert and lack immunogenicity in animals, in particular in mammals. The present invention also relates to such specific binding moieties, in particular to antibodies and/or to antigen binding fragments thereof, specifically binding to structurally disordered and/or intrinsically disordered sequences, in particular to Pro/Ala-rich sequences (PAS). These binding moieties, antibodies, antigen binding fragments are first in class since they bind to/recognize disordered peptides or polypeptide fragments as also comprised in such “intrinsically disordered proteins”, in particular PAS polypeptides. The inventive binding moieties, antibodies, antigen binding fragments are, without being limiting, particularly useful in diagnostic settings as well as research tools.

Abstract: The present invention relates to a sensor for non-invasive optoacoustic measurements of biomechanical and/or morphological features of skin and/or other tissue.

Abstract: The disclosure relates to a method for identification via channels in a system having a plurality of data processing devices. The method comprises selecting, in a first data processing device, an identifier indicative of a target second data processing device of a plurality of second data processing devices; determining, in the first data processing device, an outer codeword from the identifier using an outer code comprising a first outer code and a second outer code; determining, in the first data processing device, an optical orthogonal codeword from the outer codeword using an optical orthogonal code; determining, in the first data processing device; a randomly selected codeword from the optical orthogonal codeword using an error correction code; and emitting the selected codeword from the first data processing device via a channel. Further, a computer program product and a system for identification via channels are provided.

Abstract: A fuel cell system arranged for the conversion of pure hydrogen comprising a) at least one fuel cell comprising an anode, a cathode and an electrolyte, and arranged for an internal reformation of methane, b) a fuel conduit connecting a fuel conduit inlet with an anode inlet, c) an anode exhaust conduit connecting an anode outlet and a methanation unit capable of producing methane from anode exhaust, and d) a methanation unit exhaust conduit connecting a methanation unit exit and the fuel conduit, and e) a water removal and/or water condenser unit coupled to the methanation unit exhaust conduit, wherein the fuel introduced into an inlet of the fuel conduit is pure hydrogen, and the amount of methane produced in the methanation unit is equal to the amount of methane reformed inside of the fuel cell so that the content of methane cycling through the fuel cell system is constant.

Abstract: A method for user command-guided editing of an initial textured 3D morphable model of an object comprising: obtaining the initial textured 3D morphable model of the object comprising an initial texture map and an initial 3D mesh model of the object; and determining an edited texture map of the object corresponding to the user command by editing the initial texture map of the object based on a first artificial neural network; and/or determining an edited 3D mesh model of the object corresponding to the user command by editing the initial 3D mesh model of the object based on a second artificial neural network; and generating an edited textured 3D morphable model of the object corresponding to the user command based on the edited texture map of the object and/or the edited 3D mesh model of the object.

Abstract: The present invention provides N-methylated cyclic hexapeptides comprising RGD and at least one alanine residue. The present invention further provides prodrugs comprising the cyclic hexapeptides. Pharmaceutical compositions comprising said cyclic hexapeptides are also disclosed as well as methods of their production and use in treating integrin related conditions and diseases.

Abstract: The present disclosure relates to imaging and endoradiotherapy of diseases involving chemokine receptor 4 (CXCR4). Provided are compounds which bind or inhibit hCXCR4 and mCXCR4 and furthermore carry at least one moiety which is amenable to labeling. Provided are also medical uses of such compounds.