Abstract: A compound of formula (I) as defined herein is useful in the treatment and prevention of a disorder such as cachexia, stroke, atherosclerosis, coronary artery disease, and diabetes and pharmaceutical compositions of the same. Also, a method of screening for lipase inhibitors using a compound of formula (I) and determining its lipase inhibitory activity. The method includes in vitro assays of compounds using ATGL and/or HSL, and cellular assays wherein inhibition is followed by observing indicators of efficacy. Also, methods for treatment or prevention of a condition involving cachexia, stroke, artherosclerosis, coronary artery disease, diabetes, preferably diabetes type II by administering a pharmaceutical composition comprising an agent which is able to inhibit ATGL. Also contemplated herein, are compositions comprising one or more ATGL-inhibiting agents optionally in combination with one or more lipase inhibitors or inhibitors of inflammatory cytokines.

Abstract: A sensor system is located in an environment composed of a first medium, where waves propagate with a first phase velocity, the sensor system including at least one main enclosure and a sensor array with at least two sensors, said sensor array being arranged inside the main enclosure, wherein the space inside the main enclosure between the sensor array and the inner surface of the main enclosure is filled with a second medium, in which waves propagate with a second phase velocity, the second phase velocity being different from the first velocity.

Abstract: The present invention relates to compositions comprising an agent, like a polynucleotide, which induces or upregulates expression of UCP1 for use in treating or preventing a disorder of the energy homeostasis, overweight, adiposity, obesity, metabolic syndrome or related diseases or disorders in a subject. The present invention also relates to a method of treating or preventing a disorder of the energy homeostasis, overweight, adiposity, obesity, metabolic syndrome or related diseases or disorders in a subject comprising administrating a composition comprising a polynucleotide which induces or upregulates expression of UCP1.

Abstract: Described herein is a method for detecting a wound infection comprising the steps of: contacting a sample obtained from a wound with at least two substrates for at least two enzymes selected from the group consisting of lysozyme, elastase, cathepsin G and myeloperoxidase, and detecting a wound infection when a conversion of the at least two substrates with said at least two enzymes are determined.

Abstract: The invention relates to a method for establishing fundamental frequency curves of a plurality of signal sources from a single-channel audio recording of a mix signal, said method including the following steps: a) establishing the spectrogram properties of the pitch states of individual signal sources with use of training data; b) establishing the probabilities of the fundamental frequency combinations of the signal sources contained in the mix signal by a combination of the properties established in a) by means of an interaction model; and c) tracking the fundamental frequency curves of the individual signal sources.

Abstract: A method for analysis of analytes in a sample and to the use of such a method and a method for monitoring progress, or treatment of a disease such as fat-related disease. These analysis methods include the steps of providing the sample, measuring of values of analytes in the sample, calculating of values based on the measured values, identifying and optionally visualizing analytes can particularly be used for monitoring quantitative changes of analytes and for monitoring progress or treatment of a disease such as a fat-related disease.

Abstract: Method for compensating illumination deficiencies in microscopic “shape from focus (SFF)”, wherein firstly the reflectance of the scene is estimated by way of a projector-camera system and then microscopic “shape from focus (SFF)” is applied to a stack of reflectance maps rather than to the original image data.

Abstract: The present invention relates to a method for detecting a wound infection comprising the steps of: contacting a sample obtained from a wound with at least two substrates for at least two enzymes selected from the group consisting of lysozyme, elastase, cathepsin G and myeloperoxidase, and detecting a wound infection when a conversion of the at least two substrates with said at least two enzymes are determined.

Abstract: The invention relates to a device for the transcutaneous, in vivo measurement of the concentration of at least one analyte in a living organism, comprising a carrier which can be introduced into the organism, and a luminescence indicator which is immobilized on the carrier and which reacts to a change in the concentration of the analyte to be measured with a change in at least one optical property, wherein the luminescence indicator is transcutaneously connected to a source for providing the excitation radiation and a detector for detecting the measuring radiation. According to the invention, the luminescence indicator is immobilized on the outer circumference of a catheter, which is used to dispense a fluid medium, for example a medicament, into the organism or to suck up a body fluid.

Abstract: The invention relates to a method for localizing and tracking acoustic sources (101) in a multi-source environment, comprising the steps of recording audio-signals (103) of at least one acoustic source (101) with at least two recording means (104, 105), creating a two- or multi-channel recording signal, partitioning said recording signal into frames of predefined length (N), calculating for each frame a cross-correlation function as a function of discrete time-lag values (?) for channel pairs (106, 107) of the recording signal, evaluating the cross-correlation function by calculating a sampling function depending on a pitch parameter (f0) and at least one spatial parameter (?0), the sampling function assigning a value to every point of a multidimensional space being spanned by the pitch-parameter and the spatial parameters, and identifying peaks in said multidimensional space with respective acoustic sources in the multi-source environment.

Abstract: An assay library comprising 14 fluorescently labeled phosphonate esters which act as serine hydrolase inhibitors is provided as an analytical tool enabling activity based identification of serine hydrolases and characterization of enzyme preparations, protein mixtures and complex proteome samples.

Abstract: A receiver device for detecting a multi-band signal, the receiver device comprising a bank of autocorrelation units adapted for separating the multi-band signal into a set of autocorrelation signals, and a sampling stage arranged downstream the bank of autocorrelation units and adapted for sampling the set of autocorrelation signals to thereby select individual signal components for detection.

Abstract: A sensor system being is located in an environment composed of a first medium, where waves propagate with a first phase velocity, the sensor system including at least one main enclosure and a sensor array with at least two sensors, said sensor array being arranged inside the main enclosure, wherein the space inside the main enclosure between the sensor array and the inner surface of the main enclosure is filled with a second medium, in which waves propagate with a second phase velocity, the second phase velocity being different from the first velocity.

Abstract: A mutant Pichia pastoris alcohol oxidase 1 (AOX1) promoter of the wild type Pichia pastoris AOX1 promoter (SEQ ID No. 1) comprising at least one mutation selected from the group consisting of: a) a transcription factor binding site (TFBS), b) nucleotides 170 to 235 (?784 to ?719), nucleotides 170 to 191 (?784 to ?763), nucleotides 192 to 213 (?762 to ?741), nucleotides 192 to 210 (?762 to ?744), nucleotides 207 to 209 (?747 to ?745), nucleotides 214 to 235 (?740 to ?719), nucleotides 304 to 350 (?650 to ?604), nucleotides 364 to 393 (?590 to ?561), nucleotides 434 to 508 (?520 to ?446), nucleotides 509 to 551 (?445 to ?403), nucleotides 552 to 560 (?402 to ?394), nucleotides 585 to 617 (?369 to ?337), nucleotides 621 to 660 (?333 to ?294), nucleotides 625 to 683 (?329 to ?271), nucleotides 736 to 741 (?218 to ?213), nucleotides 737 to 738 (?217 to ?216), nucleotides 726 to 755 (?228 to ?199), nucleotides 784 to 800 (?170 to ?154) or nucleotides 823 to 861 (?131 to ?93) of Seq ID No.

Abstract: The invention relates to a method which makes use of the Zeeman effect for measuring magnetic fields, by way of dark resonances. According to said method, a measuring cell (14) is exposed to the magnetic field (B) to be measured and contains the atoms of a measuring medium in a buffer gas, a radiation source (11) being provided for exciting the atoms by radiation and being connected to the modulation frequency generator and emitting electromagnetic radiation with different frequencies. A frequency detector (17) is mounted downstream of the measuring cell (14) and comprises a control loop (18) for the frequency tuning to a dark resonance frequency.

Abstract: A method and an apparatus for magnetic induction tomography, in which an object with inhomogeneous passive electrical properties is exposed to an alternating magnetic field by excitation coils located at different positions, from which receiver coils located at different positions pick up AC signals which contain information concerning the electrical conductivity and its distribution in the object, and images of the spatial electrical properties in the interior of the object are reconstructed from the amplitudes and phases of the received signals, whereas the measurement is carried out at least 2 frequencies and an additional perturbation of the coils and/or the field geometry so as to determine a correction factor with which it is possible to widely eliminate spurious signals generated by changes of the geometry during the object measurement.

Abstract: A method and system for recovering useful information, in particular useful information transmitted in digital form on terrestrial or satellite-based information paths, for example as voice, image or data signal, from channel-coded data streams encoded with turbo codes with a predefined code rate is disclosed. The data streams are received by a turbo decoder with a presettable number of decoder components and subsequently decoded in an iterative process according to the MAP and/or Max-Log-MAP standard. The iterative process is controlled by a stop criterion, wherein after termination of the iterative process in the turbo decoder at least one of the decoder components, in particular the associated lattice diagram, is used for an additional decoding process that is different from the MAP and/or Max-Log-MAP standard. This approach lowers the error floor of the turbo code.

Abstract: An apparatus for noise suppression having a linear prediction analysis circuit having an LP error filter (LFF), which takes a first, noisy voice signal y(n)=x(n)+?(n) as a basis for producing an LP-error-filter output signal e(n), having a coefficient calculation unit (KBE), which updates the coefficients of the LP error filter on the basis of the internal signals (including the input and out signals y(n) and e(n)) in the LP error filter, and having a subtraction unit, which subtracts the LP error filter output signal e(n) from the first voice signal y(n) in a subtractor and, following the subtraction, outputs the remainder as a second voice signal x(n)=y(n)?e(n) in which the noise is suppressed.

Abstract: The invention relates to oxidized phospholipids having one of the general formulas (I) or (II) wherein A=O, C, NH, or S; B?O, C, NH, or S; and R2 is selected from the group consisting of —CO—(CH2)n—CH3; —CO—(CH2)b—CHO; and —CO—(CH2)n—COOH, with n=3-7, with the proviso that in general formula (I), R1 is selected from the group consisting of —CH2—(CH2)n—X; a —CO—(CH2)n—X with n=5-11, wherein X is a fluorophore; and in general formula (II), R1 is selected from the group consisting of —CH?CH—(CH2)n—CH3 with n=9-15; —(CH2)n—CH3 with n=11-17; and —CO—(CH2)n—CH3 with n=10-16; and R3 is selected from the group consisting of —CO—(CH2)n—X; and —SO2—(CH2)n—X, with n=0-5, wherein X is a fluorophore.

Abstract: A mutant Pichia pastoris alcohol oxidase 1 (AOX1) promoter of the wild type Pichia pastoris AOX1 promoter (SEQ ID No. 1) comprising at least one mutation selected from the group consisting of: a) a transcription factor binding site (TFBS), b) nucleotides 170 to 235 (?784 to ?719), nucleotides 170 to 191 (?784 to ?763), nucleotides 192 to 213 (?762 to ?741), nucleotides 192 to 210 (?762 to ?744), nucleotides 207 to 209 (?747 to ?745), nucleotides 214 to 235 (?740 to ?719), nucleotides 304 to 350 (?650 to ?604), nucleotides 364 to 393 (?590 to ?561), nucleotides 434 to 508 (?520 to ?446), nucleotides 509 to 551 (?445 to ?403), nucleotides 552 to 560 (?402 to ?394), nucleotides 585 to 617 (?369 to ?337), nucleotides 621 to 660 (?333 to ?294), nucleotides 625 to 683 (?329 to ?271), nucleotides 736 to 741 (?218 to ?213), nucleotides 737 to 738 (?217 to ?216), nucleotides 726 to 755 (?228 to ?199), nucleotides 784 to 800 (?170 to ?154) or nucleotides 823 to 861 (?131 to ?93) of Seq ID No.