Abstract: A method of stabilising a biological sample including glutathione (GSH) and glutathione disulfide (GSSG), including a) providing the biological sample having GSH and GSSG; b) contacting GSH and GSSG of the sample with a maleimide to obtain maleimide-alkylated GSH; c) separating excess maleimide from maleimide-alkylated GSH and GSSG; d) contacting maleimide-alkylated GSH and GSSG with a reducing agent such as TCEP under conditions which allow reduction of GSSG by the reducing agent such as TCEP to obtain further GSH; and e) contacting maleimide-alkylated GSH and GSH with a heavy isotopologue of the maleimide to obtain a heavy isotopologue of the maleimide-alkylated GSH. A stabilised biological sample is provide containing maleimide-alkylated GSH and a heavy isotopologue thereof, as well as a mass-spectrometric method for quantifying maleimide-alkylated GSH and a heavy isotopologue thereof in a sample and a kit for stabilising a biological sample including GSH and GSSG for mass spectrometric analysis.

Abstract: The invention relates to a medical analysis device (1) for assessing a patient's suitability for anaesthesia by analysing at least one physiological biosignal (S) detected during an apnoea, wherein the medical analysis device (1) comprises the following: —an input interface (2) for detecting a time curve of at least one physiological biosignal (S) of a patient, —a computing unit (3) which is configured to compare a time curve of the at least one physiological biosignal (S) with at least one predefinable curve or a limit value according to an algorithm (4) in order to determine a patient's suitability for anaesthesia and to calculate an assessment result (E) depending thereon, wherein the time curve of the at least one physiological biosignal (S) comprises at least the duration of a patient's apnoea, and —an output interface (5) connected to the computing unit (3), to output the assessment result.

Abstract: The present invention relates to a microfluidic device (1; 8) for the production of cellular spheroids comprising at least one chamber (2; 9) comprising a fluid inlet (3) for introducing fluid into the chamber (2; 9) and a fluid outlet (4) for removing said fluid from the chamber (2, 9), wherein said at least one chamber (2; 9) comprises a base formed by a substrate (5; 10) comprising at least two recesses (6; 11) to collect a fluid comprising biological cells when the substrate (5, 10) is contacted with the fluid, wherein the size of the at least two recesses (6; 11) decreases from the fluid inlet (3) to the fluid outlet (4) of the at least one chamber (2; 9).

Abstract: The present invention relates to transmission elements (1, 1a, 1b; 12, 12a, 12b) for testing/determining the tensile or shear strength of a bonding between two elongated shaped specimen elements by transmitting a tensile or shear force (10, 22) to a specimen element (5a, 5b; 12a, 12b).

Abstract: A method for analyzing or optimizing the operation of waste incinerator systems. The content of CO2 is measured in the exhaust gas and is used to determine the ratio of biogenic carbon to fossil carbon in the incinerated waste, if necessary after resetting to the CO2 reference quantity. The variability of the CO2 reference or the ratio of biogenic carbon to fossil carbon in the incinerated waste is determined and recorded according to quantity and duration. When optimizing the operation, the location of the waste in the bunker, from which the incinerated waste originates with a composition or variability that has now been ascertained using the method, is used to further remove or mix the waste.

Abstract: In a method of controlling a lithography-based additive manufacturing device capable of manufacturing a three-dimensional component from a plurality of volume elements, a check is made to determine whether the volume elements are entirely within the three-dimensional virtual model by identifying at least first and second boundary points of the volume element or virtual model in x-y planes spaced apart in the z-direction, and the volume element in question is provided for the manufacturing process only if it is within the model with respect to the first and second boundary points.

Abstract: A method for demodulation including the following steps: exciting a vibrationally mounted, at least sectionally bar-shaped oscillating element for oscillating in the range of a resonance frequency of the oscillating element, wherein a temporally varying, in particular periodic, excitation signal is used for excitation, and wherein at least the temporal variation of the excitation signal is known or determined; detecting a modulated oscillation of the oscillating element by means of at least one sensor, wherein the sensor supplies a sensor measurement variable that varies versus time as a function of an amplitude and a phase of the modulated oscillation of the oscillating element. According to the present teaching, it is provided that the method includes the following step: generate a first comparison signal by amplitude modulating a known temporally varying, in particular periodic, demodulation signal by means of the temporally varying sensor measurement variable.

Abstract: A method of producing a test body for diffusion tensor imaging, which comprises a plurality of channels in a structuring material, the channels preferably having a maximum cross-section of 625 ?m2, wherein a virtual model of the test body is created and the virtual model is fed to a structuring device which produces the test body by means of a 3D printing-based, in particular lithography-based, structuring process, the structuring process being designed as a multiphoton lithography process, in particular as a multiphoton absorption process, in which the structuring material containing a photosensitizer or photoinitiator is irradiated in a location-selective manner, wherein the radiation is successively focused on focal points lying within the structuring material, resulting in that in each case a volume element of the material located in the focal point is subjected to a change in state by means of a photochemical reaction as a result of multiphoton absorption.

Abstract: A redirecting rotating mirror arrangement includes a directional antenna subcomponent having a direction of maximum received or transmitted beam intensity. The redirecting rotating mirror arrangement also includes a rotatable mirror that reflects an electromagnetic beam to or from the directional antenna subcomponent. The rotatable mirror is inclined at an inclination angle with respect to a horizontal plane. The arrangement also includes a motor that rotates the rotatable mirror about the direction of maximum received or transmitted beam intensity such that the electromagnetic beam is either received from or transmitted to a range of angles as the rotatable mirror rotates.

Abstract: A laser assembly comprising: a semiconductor laser with a fast gain medium, wherein the gain relaxation time of the gain medium is smaller than the round-trip time in a standing wave cavity; a DC source coupled to the standing wave cavity; and an AC injection device for injecting an electrical AC signal within a range and/or within an integer multiple of the range into the standing wave cavity, the range within ±1% of the natural round-trip frequency in the standing wave cavity, comprising at least a first and second electric contact section extending along a first longitudinal side of the longitudinal extension of the standing wave cavity, the AC injection device coupled to the first and/or second electric contact section such that the complex amplitude of the electrical AC signal differs for the first and second longitudinal electric contact section.

Abstract: The invention relates to a tunnel lining segment of reinforced concrete, wherein the tunnel lining segment has a load transfer area for a longitudinal joint, with at least one steel bar with an end face being installed in the tunnel lining segment, the steel bar being arranged in the tunnel lining segment in such a way that a tangent to a centroidal axis of the steel bar encloses an angle of between 0° and 45° in the end face with a normal to the load transfer area, and wherein the end face is arranged at a distance (a) from the load transfer area which is between 0 mm and 50 mm, preferably between 0 mm and 10 mm.

Abstract: The present invention relates to a method for producing shaped bodies (5) from a building material, in which a layered structure of a shaped body (5) takes place by successively solidifying layers of the building material by exposure to electromagnetic radiation in a layer area having a contour specified for the respective layer. The method provides that together with the shaped body (5), a sleeve-like frame (6) surrounding the shaped body at a distance is constructed layer by layer from the building material, and that in addition, a plurality of pin-like connections (10) are constructed integral with the frame (6) and the shaped body (5), which are distributed around the shaped body (5) and which connect the shaped body (5) with the frame (6).

Abstract: The invention relates to a device for connecting a cannula to a container under reduced pressure, in particular a blood culture flask, including an inflow opening for connecting to the cannula or to a connection tube connected to the cannula, an outflow opening for connecting to a hollow pin for piercing a closure of the container, and a tight fluidic connection of the inflow opening to the outflow opening. According to the invention, a reservoir which is separated from the fluidic connection and contains a specified gas quantity is connected to the fluidic connection with the interposition of a valve which is preferably open towards the fluidic connection.

Abstract: The invention relates to a stoichiometric salt of a tetracarboxylic acid and a diamine of the following general formula (I), wherein R1 is selected from tetravalent residues of butane, cyclobutane, cyclopentane, cyclohexane, tetrahydrofurane and benzophenone and R2 is selected from divalent residues of unbranched, branched or cyclic aliphatic hydrocarbons with 3 to 15 carbon atoms, with the proviso that the salt of the formula (I) is water-soluble and is selected from compounds (1) to (28); and to the polyimides prepared from these salts by polycondensation.

Abstract: The invention relates to a method for preparing polybenzimidazoles of formula (1) or (2) below, wherein n is ?2: by polycondensation of corresponding dicarboxylic acids or dialdehydes and tetraamines by jointly heating the reactants, characterized in that the preparation of polybenzimidazoles of formula (1) or (2) is carried out by using the dialdehydes as starting material and substantially without the formation of any intermediates, wherein a) first, the dialdehyde and the tetraamine are mixed in water at room temperature, which results in the formation of a polyimine by-product; whereafter b) polycondensation is carried out under hydrothermal conditions by heating, in water as a solvent and under pressure, to temperatures above 100° C.

Abstract: A safety system is provided for a machine tool which has a frame and a tool. The safety system has a clamping device and a motion device. The clamping device is movable by the motion device from a working position, in which the tool is extended and can be used for working, to a safety position, in which the tool is retracted. The motion device has a first magnetic means connected to or arranged on the tool and a second magnetic means connected to or arranged on the frame, such that movement of the tool by the motion device from the working position to the safety position can be triggered and/or at least partially performed by magnetic force.

Abstract: A light-curable composition is provided which may be used as a photopolymerizable material in an additive manufacturing process. The additive manufacturing process involves heating the light-curable composition which has a viscosity at 20° C. of at least 20 Pa·s. The light-curable composition includes a photopolymerizable matrix material, at least one thermoplastic polymer dissolved therein, and at least one photoinitiator. Polycaprolactone or a derivative thereof is used as the dissolved thermoplastic polymer.

Abstract: A computer-implemented method and an electronic device for detecting, in an electrical circuit with electrical components (Mg) subject to variations (?) of their model parameters (xj), those components (Mg*) the model parameter variations (?) of which have the strongest influence on a performance (yn) of the circuit, comprising: providing a topology (Q) of the circuit and the model parameters (xj) of all components (Mg) therein; determining, therefrom, topological patterns (Pk) of interconnected components (Mg); generating variation samples (vn), each comprising a different set of candidate variations (x?j) of the model parameters (xj); calculating, for each variation sample (vn), the circuit's performance (yn) and a deviation from a standard performance and forming a deviation vector (yD) therefrom; and using the variation samples (vn), the deviation vector (yD) and the topological patterns (Pk) in a regression model for detecting the most influential components (Mg*).

Abstract: Method and apparatus to produce a wideband RF signal covering an increased first bandwidth, utilizing at least one narrowband transceiver (1) capable of producing an output RF signal with a base frequency fbase and a second bandwidth, wherein the second bandwidth is lower than the first bandwidth, and wherein the base frequency Case depends on the setting of at least one frequency register (2, 2?, 2?), which is adjustable by a control unit, as well as method to estimate the position of a narrowband RF transceiver (1) using a multitude of coherent wideband RF receivers (12) and computer-readable medium comprising computer-executable instructions causing an electronic device to perform the method.

Abstract: A method for automatic detection of a functional primitive in a model of a hardware system, the model being a netlist having cells and net links therebetween, comprising the steps: a) mapping the cells to target nodes, each of which having a target node type, and the net links to edges of a target graph, and mapping the functional primitive to a search pattern having search nodes and connections therebetween; b) selecting candidates from those target nodes the target node types of which match a search node type, and selecting a candidate structure from those selected candidates the target nodes and edges of which match the search nodes and connections of the search pattern; c) reverse-mapping the target nodes and edges of the selected candidate structure to the cells and net links of the netlist; and d) outputting said cells and net links as detected functional primitive.