Abstract: A small-sized, portable enclosure protects a gas sensor against degradation due to environmental exposure and changes in atmospheric conditions. The protective enclosure includes an inlet for introduction of a gas into the enclosure, an outlet for release of the gas upon completion of a sensing run, and at least one retractable filter that removes from the inflowing gas deleterious compounds that can compromise the integrity of the sensor or cause the sensor to degrade over time. The enclosure does not include any filters during the measurement phase of the sensing run in order to allow the gas sensor to accurately measure an unmodified gas mixture and/or analyte.

Abstract: An apparatus arranged for deflecting an optical component for alignment purposes of the optical component with a further optical component, wherein the apparatus comprises a plurality of adjacently placed elongate carriers, extending mutually parallel to each other in a longitudinal direction, wherein two adjacently placed elongate carriers have a spacing between them for receiving a first optical component such that the received optical component rests against two adjacently placed elongate carriers, wherein the two elongate carriers have slopes such that the spacing between the two adjacently placed elongate carriers is smaller at a bottom side compared to the spacing at a top side of the carriers, wherein the carriers comprise piezoelectric material configured to deflect the carriers in a direction perpendicular to the longitudinal direction by actuating the piezoelectric material.

Abstract: A closed-cycle thermal energy storage system includes a thermochemical reactor [400] containing a solid thermochemical material, a heat exchanger [402], a fan [406] for creating forced convection of an air/water mixture circulating around the closed cycle, an evaporator/condenser [408], and a pressure control system that includes a pressure sensor [422], a controller [424], and a pump [404]. The pressure control system actively controls the pressure of the air/water mixture to produce a desired temperature difference across the thermochemical reactor [400]. The adjustable pressure control system controls the pressure of the air/water mixture to a first pressure (e.g., between 10 mbar and 1 bar) during a hydration phase and a second pressure (e.g., between 1 bar and 10 bar) during a dehydration phase.

Abstract: A device for generating soft x-rays includes an electron source configured to generate an electron beam comprising electron micro-bunches; an electron accelerator configured to accelerate the electron micro-bunches from the electron source; and a laser configured to generate a laser beam (536) colliding with the accelerated electron micro-bunches (534) in a counterpropagating direction to generate the soft x-rays by inverse Compton scattering. The electron source has a magneto-optical trap configured to produce an ultracold atomic gas; two counterpropagating excitation laser beams configured to produce a standing wave for inducing a periodic spatial modulation of the ultracold atomic gas along a beam propagation direction; and an ionization laser configured to induce photo-ionization of the ultracold atomic gas.

Abstract: Provided herein is a method for biosensing a target substance [110] using a collection of particles [104] tethered to a surface [100] by tether molecules [102] and a plurality of capture molecules. A concentration of the target substance is determined from the time sequence of individual association/dissociation rates of the capture molecules. Competitive assay configurations are also described.

Abstract: An optical beam steering device is provided that includes an input optical fiber carrying multiple input optical signals, where each input optical signal includes a unique wavelength, an arrayed waveguide grating router (AWGR) having multiple output fibers, where the input optical fiber is connected to the AWGR, distal ends of the output fibers are arranged in a two-dimensional fiber array, the input optical signals are routed by the AWGR according to each unique wavelength to a unique AWGR output fiber, and a lens, where the distal ends of the output fibers are disposed proximal to a focal plane of the lens, where for each unique position of each output fiber distal end with respect to a the lens, each input optical signal is steered at a unique angle as an output beam emitted from the lens, where changing the wavelength of the input optical signal changes the output signal angles.

Abstract: A small-sized, portable enclosure protects a gas sensor against degradation due to environmental exposure and changes in atmospheric conditions. The protective enclosure includes an inlet for introduction of a gas into the enclosure, an outlet for release of the gas upon completion of a sensing run, and a number of in-line filters that remove from the inflowing gas sample analytes, contaminants, and other materials that can compromise the integrity of the sensor or cause the sensor to degrade over time. The enclosure does not include any filters during the measurement phase of the sensing run in order to allow the gas sensor to accurately measure an unmodified gas mixture and/or analyte.

Abstract: A biosensing device for continuous monitoring of an analyte in a fluid matrix includes an electromagnetic excitation element [402], a biosensing surface [406], an opposing surface [410], a separation component [420,422], light collection optics [412], a light sensor [414], an image recording and analysis system [416], and an excitation control system [400]. The separation component is connected to the biosensing surface and to the opposing surface, forming a concave gap region [408] between the biosensing surface and the opposing surface. The biosensing surface comprises biosensing particles sensitive to electromagnetic signals from the electromagnetic excitation element, where an optical response of the biosensing particles to the electromagnetic signals is adapted to change in the presence of an analyte in the gap region. The light collection optics couple light emitted from the biosensing particles on the biosensing surface to the light sensor.

Abstract: Culturing of organized 3D networks of neuronal cells is provided. Individual neuronal cells are encapsulated in gel beads. The gel beads are self-assembled into ordered structures in a bioreactor. Subsequent culturing of the cells in the bioreactor leads to the formation of an organized 3D network of the neuronal cells. Such structures have many applications, especially for as says of neuronal network function and/or structure.

Abstract: A seven-degrees of freedom modular robotic device is provided for controlling an instrument, e.g. a bone-drilling or milling device with a precision of about 50 ?m and maximum force of 50 N. The robotic device is a serial kinematic chain of six rotational degrees of freedom and one translational degree of freedom.

Abstract: A method for sensing an analyte uses tethered particle motion. A functionalized particle has a first state in which the functionalized particle is bound to the surface and a second state in which the functionalized particle is not bound to the surface, where the functionalized particle switches between the first and second states depending on the presence and absence of the analyte, thereby changing motion characteristics of the functionalized particle depending on the presence of the analyte. A spatial coordinate parameter of the functionalized particle is measured by a detector, and a processor determines the presence/concentration of the analyte from changes in the measured spatial coordinate parameter.

Abstract: A hard-decision (HD) forward error correcting (FEC) coded signal is decoded by a decoder to produce decoded bits using marked reliable bits of the HD-FEC coded signal and marked unreliable bits of the HD-FEC coded signal. The marked reliable and unreliable bits are computed by calculation and marking blocks based on an absolute value of log-likelihood ratios of the HD-FEC coded signal. The HD-FEC coded signal may be, for example, a staircase code coded signal or a product code coded signal.

Abstract: A supramolecular polymer blend includes a thermoplastic elastomer functionalized with at least one bis-urea moiety and a functional component which is functionalized with at least one bis-urea moiety which is present in an amount of 0.5-40 wt % based on the total mass of the polymer blend. The functional component is selected from polyalkylene glycol, betaine, polysaccharide, zwitterion, polyol or taurine and derivatives thereof. Implants including the polymer blend and a process to manufacture the implants are also provided.

Abstract: A surgical robot for performing minimally invasive surgery (e.g. in the eye) is provided. A cannula connection is positioned at a fixed surgical arm part and aligned with a movable surgical arm part movable with respect to the fixed surgical arm part. A surgical instrument can be mounted at the movable part. The surgical instrument can pass through the cannula connection. Reference arm(s) and manipulation arm(s) connect a base element with the fixed surgical arm part. The base element could have a surgical operating table attachment part to movably attach to a surgical operating table and rotating parts movably attached to the surgical operating table attachment part.

Abstract: An ostomy pouching device is configured to allow two-way flow of gas between the device and a stoma bag (100). A check valve (104) is configured to allow ambient air into a channel of the device, and thereby into the stoma bag, when a pressure of the gas in the channel is less than a pressure of the ambient air; another check valve (105) is configured to allow gas to flow into a deodorizing reactor (110) when a pressure of the gas in the channel is greater than a pressure of the ambient air. The deodorizing reactor includes a plasma reactor configured to generate plasma in the channel for deodorizing the gas in the channel before being expelled from the device into the ambient air. The plasma reactor is preferably a dielectric barrier discharge (DBD) reactor. It may also include a secondary active carbon filter.

Abstract: A fully integrated Òsample-in-signal-out Ó microfluidic paper-based analytical devices are provided relying on bioluminescence resonance energy transfer (BRET) switches for target analyte recognition and colorimetric signal generation. Simultaneous colorimetric detection and quantification of multiple antibodies in a single drop of whole blood is shown. The devices make use of BRET-based antibody sensing proteins integrated into vertically assembled layers of functionalized porous layer(s) of material. The device enables sample volume independent, eliminates addition of reagents to the sample, and has on-device blood plasma separation. User operation is a single drop of a sample and the acquisition of a photograph after sample introduction, with no requirement for precise pipetting, liquid handling or analytical equipment except for a camera. Using different antibodies as targets, simultaneous detection in whole blood was achieved.

Abstract: Pressure sensing having 2-D resolution is provided by an array of optical waveguides having wave-guide intersections (e.g., intersecting rows and columns). Pressure induced cross-coupling between intersecting wave-guides is enhanced by including mechanical structures at each intersection that enhance local waveguide bending. For example, such structures can be rigid rings around the wave-guide intersections.

Abstract: An artificial cartilage is provided whereby a fixed negative charged hydrogel has been infused within a restrictive swelling network, which limits and restricts the thickness of the artificial cartilage. At least 60% of the volume of the artificial cartilage is composed of the restricted and swollen hydrogel. The restrictive swelling network restricts the hydrogel to swell not more than 10% with respect to its maximum swelling capacity, i.e. a swelling capacity to swell 10-fold more is retained. The hydrogel within the restrictive swelling network has an equilibrium stiffness between 0.5 and 2 MPa to resist external loads applied to the top surface layer or the bottom surface layer of the artificial cartilage. The hydrogel has a fixed negative charge density of ?0.17 to ?0.23 mEg/ml and is capable of swelling between 2-15 times compared to the volume of the hydrogel without being restricted.

Abstract: A double membrane microspectrometer is provided that includes a first membrane having a first and second doped semiconductor layers, and a first intrinsic layer is disposed between the first and second layers, where the first intrinsic layer includes an optically absorbing material, a first pattern of through holes are disposed perpendicular through the first membrane having lateral support arms, a second membrane having a third doped layer and a fourth layer is an intrinsic layer or a doped layer, where the second membrane includes a second pattern of through holes, where the first membrane is separated from the second membrane by an insulating bridge layer and is supported above the second membrane by lateral support arms, where an absorption spectrum of the absorbing material is dependent on the separation distance of the membranes, electrodes are disposed on the first layer, the second layer, and the third layer operate the separation.

Abstract: A method of object recognition trains a convolutional neural network (CNN) with a set of training images, then classifies an image of an object using the trained CNN. A first layer of the CNN is trained by generating a set of first convolutional filters from eigenvectors produced from linear principal component analysis of patches of the training images. The training of each of multiple hidden layers CNN includes generating a set of convolutional filters from a selected subset of eigenvectors produced from linear principal component analysis of patches of an affinity matrix constructed using a set of prior convolutional filters from a prior layer of the CNN, where the affinity matrix represents correlations of feature vectors associated with the prior layer. The last layer of the CNN is trained with a regular classifier by error back-propagation using the training images and labels associated with the training images.