Abstract: The present invention provides methods of treating proliferative disease in a patient (e.g., a mammal such as a human) in need of such treatment, said treatment comprising administering, concurrently or sequentially, an effective amount of (1) an anti-platelet or anti-clotting agent and (2) an anti-neoplastic agent and/or radiation therapy. A second method of treatment comprises administering Plavix, also known as clopidogrel, or SR 25909 to a patient in need of such treatment. An additional method comprises administering an anti-platelet or anti-clotting agent to an individual at risk for developing proliferative disease. The methods of the present invention are particularly useful for the treatment or prevention of various cancers, especially epithelial cancers, e.g., prostate cancer, lung cancer, breast cancer, colorectal cancer, and pancreatic cancer.

Abstract: Pixel element for a programmable patterning structure (e.g. a spatial light modulator) which can simultaneously modulate both phase and amplitude. Use of such a programmable patterning structure with lithographic projection apparatus is also described.

Abstract: Apparatus and methods for compensating for the movement of a substrate in a lithographic apparatus during a pulse of radiation include providing an optical structure configured to move a patterned projection beam incident on the substrate in synchronism with the substrate.

Abstract: A membrane penetrating closure device for a container on which a sealing membrane (e.g., a metal foil) is installed. The membrane penetrating closure includes a cap that is designed to be engaged on the container. The cap is sealed by a user deformable portion that includes a pressure application surface. A penetrating structure with a cutting edge is connected to the user deformable portion such that it extends towards the membrane when the container and closure are engaged. Retaining structure is provided to retain a severed portion of the membrane within the penetrating structure. In one embodiment, the retaining structure comprises a plurality of capture projections that extend inwardly from the cutting edge. In another embodiment, the retaining structure is a spear projection that extends beyond the cutting edge. Other embodiments are described wherein the severed portion of the membrane remains connected to unsevered portions of the membrane.

Abstract: A wave-power generator assembly including a pair of one-way turbines symmetrically mounted on a common rotating shaft is provided. Because of the symmetrical arrangement of the one-way turbines, the rotating shaft and, therefore, bearings to rotatably support the rotating shaft are prevented from receiving excessive thrust forces. Thus, the present generator assembly may be presented to service for an extended period of time without requiring replacement of parts.