Abstract: Disclosed in this specification is a method for identifying at least one aptamer that can bind to a bio-molecular target. The aptamer is designed in silico based on the structure of the target molecule. The process includes the steps of determining a first seed residue and growing an oligomer, one residue at a time, while maximizing the entropy of target-oligomer complex or minimizing the binding energy after the addition of each oligomer.

Abstract: A bicontinuous optical switching structure includes a predetermined number of tunnels coated with a reflective material or a very smooth. The tunnels provide pathways from one side of bicontinuous optical switching structure to another. Each tunnel represents an entry point having a multitude of entry angles. Since the angle of entry dictates the exit point, a single tunnel can represent multiple entry/exit point pairs. A three-dimensional circuit may include a hyperbolic bicontinuous structure forming a substrate; circuits formed on a first surface of the hyperbolic bicontinuous structure; and electrically conductive traces formed between the circuits. The electrically conductive traces are formed two-dimensionally on the first surface of the hyperbolic bicontinuous structure. The electrically conductive traces are effectively three-dimensional traces between the circuits.

Abstract: An apparatus for the electronic display of information, where the apparatus is a substrate incorporating a digital recording medium attached to or embedded within the substrate. The substrate further includes a flexible-substrate display located on an exposed surface of the substrate, where the display is a medium capable of selectively displaying one of at least two possible colors at each pixel location thereon in order to produce a substrate medium that may be modified in accordance with a user's selection.

Abstract: An apparatus for the electronic display of information, where the apparatus is a substrate incorporating a digital recording medium attached to or embedded within the substrate. The substrate further includes a flexible-substrate display located on an exposed surface of the substrate, where the display is a medium capable of selectively displaying one of at least two possible colors at each pixel location thereon in order to produce a substrate medium that may be modified in accordance with a user's selection.

Abstract: Disclosed in this specification is a method for identifying at least one aptamer that can bind to a bio-molecular target. The aptamer is designed in silico based on the structure of the target molecule. The process includes the steps of determining a first seed residue and growing an oligomer, one residue at a time, while maximizing the entropy of target-oligomer complex or minimizing the binding energy after the addition of each oligomer.

Abstract: An apparatus for the electronic display of information, where the apparatus is a substrate incorporating a digital recording medium attached to or embedded within the substrate. The substrate further includes a flexible-substrate display located on an exposed surface of the substrate, where the display is a medium capable of selectively displaying one of at least two possible colors at each pixel location thereon in order to produce a substrate medium that may be modified in accordance with a user's selection.

Abstract: An apparatus for the electronic display of information, where the apparatus is a substrate incorporating a digital recording medium attached to or embedded within the substrate. The substrate further includes a flexible-substrate display located on an exposed surface of the substrate, where the display is a medium capable of selectively displaying one of at least two possible colors at each pixel location thereon in order to produce a substrate medium that may be modified in accordance with a user's selection.

Abstract: A coherent radiation imaging system that produces digital images with a reduced amount of speckle. Radiation from a long coherence length source is used to form an image of a sample. The output coherent wave is temporally divided into a plurality of wavelets. The spatial phase of each wavelet is then modulated a known and different amount. Each phase modulated wavelet illuminates the sample and is perturbed by its interaction with the sample. A spatial phase map of each perturbed wavelet is then created and converted to a sample image with an image reconstruction program. The plurality of sample images thus formed is statistically averaged to form a final averaged image. The high frequency speckle that is not optically resolvable tends to average to zero with continual statistical averaging, leaving only the optically resolvable lower frequency phase information.

Abstract: An apparatus for the electronic display of information, where the apparatus is a substrate incorporating a digital recording medium attached to or embedded within the substrate. The substrate further includes a flexible-substrate display located on an exposed surface of the substrate, where the display is a medium capable of selectively displaying one of at least two possible colors at each pixel location thereon in order to produce a substrate medium that may be modified in accordance with a user's selection.

Abstract: A coherent radiation imaging system that produces digital images with a reduced amount of speckle. Radiation from a long coherence length source is used to form an image of a sample. The output coherent wave is temporally divided into a plurality of wavelets. The spatial phase of each wavelet is then modulated a known and different amount. Each phase modulated wavelet illuminates the sample and is perturbed by its interaction with the sample. A spatial phase map of each perturbed wavelet is then created and converted to a sample image with an image reconstruction program. The plurality of sample images thus formed is statistically averaged to form a final averaged image. The high frequency speckle that is not optically resolvable tends to average to zero with continual statistical averaging, leaving only the optically resolvable lower frequency phase information.

Abstract: A coherent radiation imaging system that produces digital images with a reduced amount of speckle. Radiation from a long coherence length source is used to form an image of a sample. The output coherent wave is temporally divided into a plurality of wavelets. The spatial phase of each wavelet is then modulated a known and different amount. Each phase modulated wavelet illuminates the sample and is perturbed by its interaction with the sample. A spatial phase map of each perturbed wavelet is then created and converted to a sample image with an image reconstruction program. The plurality of sample images thus formed is statistically averaged to form a final averaged image. The high frequency speckle that is not optically resolvable tends to average to zero with continual statistical averaging, leaving only the optically resolvable lower frequency phase information.

Abstract: A colchicine derivative and a method of using a colchicine derivative as a pharmacological agent in the treatment of malaria are provided.

Abstract: An assembly is provided for the direct measurement of a vertical intensity profile through a plane of focus of a confocal microscope, a determination of a depth of the confocal plane and a maximum intensity of the intensity profile. The assembly includes a transparent substrate in which is embedded a scale having a graduated length, wherein the scale is inclined relative to a local portion of an illuminating beam on an illuminating path of the confocal microscope. The graduated scale is configured to be illuminated with an intensity corresponding to the position within the plane of focus along the axis of the illuminating beam. The inclination of the scale and the path of the illuminating beam are at a predetermined angle. The graduated scale can be fluorescently dyed to illuminate with an absorption frequency relevant to a light source or illuminating beam of the confocal microscope. An algorithm employing trigonometric functions and calculating the confocal plane depth of the specimen is disclosed.

Abstract: Apparatus and method for quantifying the oil and water fractions of a multi-phase flow stream and their respective flow rates. The hydrocarbon fractions are determined based on information gathered on their respective refractive indices when exposed to particular wavelengths of light.

Abstract: Apparatus and method for quantifying the biological components of a biological system having at least two different refractive indices through detection of wave front distortions. The biological component fractions are determined based on information gathered on their respective indices when exposed to particular wavelengths of light.

Abstract: A speech-driven control device for a media system includes a housing; a controller; a first communication port to enable communication of instructions between a data processing system and the controller; and a second communication port to enable communication of instructions between a media device and the controller. The controller includes a speech recognition system to recognize human speech and to convert the human speech into a first set of commands and into a second set of commands. The first set of commands provides instructions to the data-processing system to enable speech driven control of a media presentation. The second set of commands provides instructions to the media device to enable speech driven control of a functionality of the media device.

Abstract: The present invention is a method and an apparatus for controlling the volume of a printable substrate after an image is created thereon, and more particularly to the production and use of a calenderizeable substrate in which a final thickness may be adjusted. The system employed for the process includes a pair of compression rollers wherein the nip force therebetween may be adjusted.

Abstract: Techniques for controlling distribution of information from a secure domain by automatically detecting outgoing messages which violate security policies corresponding to the secure domain. Semantic models are constructed for one or more message categories and for the outgoing messages. The semantic model of an outgoing message is compared with the semantic models of the message categories to determine a degree of similarity between the semantic models. The outgoing message is classified based on the degree of similarity obtained from the comparison. A determination is made, based on the classification of the outgoing message, if distribution of the outgoing message would violate a security policy for the secure domain. Distribution of the outgoing message is allowed if no security policy is violated.

Abstract: A fully integrated portable personal computing device includes a lid body member and a main body member. An input system inputs data and commands and a microprocessor processes the data in accordance with the commands. A display system displays information. The display system is located in the lid body member. A projection system is integrally included in the portable personal computing device for projecting the information displayed on the display system to an area remote of the portable personal computing device. The projection system can also be a peripheral plug-in device for replacing a floppy disk drive peripheral for the portable personal computing device.

Abstract: Disclosed is the operation of actuators, and particularly microactuators, by the application of energy other than through conventional sources of heating, including fiber optics for both control/feedback and energy delivery.