Abstract: FGF2-binding peptides are here described, which have been designed starting from the N-terminal region of PTX3, in particular spanning the PTX3(82-11O) region. Synthetic peptides related to this sequence are able to bind FGF2 and to inhibit its pro-angiogenic activity in vitro and in vivo with no anticipated impact on innate immunity.
Type:
Grant
Filed:
January 23, 2007
Date of Patent:
December 13, 2011
Assignee:
Tecnogen S.p.A.
Inventors:
Marco Presta, Maura Camozzi, Marco Rusnati, Maurizio Colombo, Domenico Mastroianni
Abstract: It is described the use of the long pentraxin PTX3 (PTX3) or one of its functional derivatives, for the preparation of a medicament for the prevention or treatment of viral diseases and/or for inhibiting virus activation.
Type:
Application
Filed:
February 15, 2011
Publication date:
September 15, 2011
Applicant:
TECNOGEN S.P.A
Inventors:
Paolo Carminati, Marica Sassano, Francesco Bistoni, Luigina Romani, Silvia Bozza
Abstract: It is described a vector suitable for efficient selection and/or maturation of a recombinant antibody characterized in that it contains at least one element able to reduce the expression level and/or has an improved efficiency of display of said recombinant antibody.
Type:
Grant
Filed:
December 27, 2006
Date of Patent:
August 23, 2011
Assignees:
Sigma Tau Industrie Farmaceutiche Riunite S.pA., Tecnogen S.p.A.
Abstract: It is described the use of the long pentraxin PTX3 (PTX3) or one of its functional derivatives, for the preparation of a medicament for the prevention or treatment of viral diseases and/or for inhibiting virus activation.
Type:
Grant
Filed:
February 28, 2007
Date of Patent:
March 22, 2011
Assignee:
Tecnogen S.p.A.
Inventors:
Paolo Carminati, Marica Sassano, Francesco Bistoni, Luigina Romani, Silvia Bozza
Abstract: It is described the use of the long pentraxin PTX3 (PTX3) or one of its functional derivatives, for the preparation of a medicament for the prevention or treatment of viral diseases and/or for inhibiting virus activation.
Type:
Application
Filed:
February 28, 2007
Publication date:
November 19, 2009
Applicant:
TECNOGEN S.P.A.
Inventors:
Paolo Carminati, Marica Sassano, Francesco Bistoni, Luigina Romani, Silvia Bozza