Abstract: Porous biocompatible composite biomaterial, useable as a drug delivery system or as spacer or as bone substitute, such as for example for filling bone lacunae or for substituting damaged parts of bone tissue, or for fixing prosthesis of various types, or for thickening bones weakened by illness such as osteoporosis or the like, including a component adapted to form a porous structural matrix and a soluble component, wherein the soluble component is in form of powder and granules or other similar agglomerates so as to have mechanical support characteristics and osteoinductive and osteoconductive characteristics in the entire volume occupied by the biomaterial, and a method for obtaining the biomaterial.

Abstract: Mixer for obtaining bone cement for medical applications comprising a mixing chamber in which the mixing of at least two components which form the cement is carried out, comprising means for generating and transmitting vibrations to the mixing chamber and a luer attachment through which the cement can exit.

Abstract: The present invention has its application in the field of devices and methods for the product physical and chemical mixing and refers particularly to a cartridge for sterile mixing of a two-phase compound. The cartridge includes a first tubular body defining a first collection chamber for a solid phase, a second tubular body defining a second collection chamber for a liquid phase, means for transferring the liquid phase from the second to the first chamber, means for mixing the phases. The means for mixing comprise means for agitating acting on the mixture inside the first chamber with the first tubular body in substantially stationary conditions, so as to favor the dispersion of the solid phase inside the liquid phase thus obtaining a compound with uniform physical and mechanical properties.

Abstract: A spacer device for the two-stage treatment of infections of the prosthesis of the human limbs, made of biologically compatible material adapted to be added and/or which can be added with pharmaceutical products, active and/or therapeutic ingredients, includes a first portion adapted to be fixed to a corresponding bone bed, and a second portion adapted to be inserted in a corresponding articular area of the patient, said first portion and said second portion being connected through adjustable joining means. The device includes mutual coupling surfaces respectively provided in said first portion and said second portion coated with said biologically compatible material. A method for locking the first portion to the second portion is also provided.

Abstract: Disposable modular spacer device of the articulation of a knee including a tibial element, constrainable to an end of the tibial bone in proximity of the articulation of the knee and including a lower surface and an upper surface provided with a radius of curvature R2, and a femoral element, including an inner surface, constrainable to an end of the femoral bone at the articulation of the knee and an outer convex surface, provided with a radius of curvature R1 and in contact with the upper surface of the tibial element, the tibial element and the femoral element having various dimensions or sizes, the tibial element being configured so as to be coupled with any size of the femoral element to adapt the dimensions of the modular spacer device with the dimensions of the bone ends to which it should be connected.

Abstract: Dispensing unit for mixers of biphasic compounds, for dispensing a quantity of mixed biphasic compound through a channel of at least a mixing unit by means of at least a piston sliding inside at least a mixing chamber, wherein it includes at least a drive element for said piston which can be remotely controlled.

Abstract: Mixer for biphasic compounds, including a chamber for containing a solid phase and a cartridge containing a phial of a liquid phase, said chamber and said cartridge being able to communicate through respective channels, wherein said cartridge includes an external casing made in a deformable material and said phial is of the breakable type.

Abstract: A disposable device for treatment of infections of human limbs, particularly limbs having long bones susceptible to stabilization by intramedullary nailing. The device includes a tubular member made of a relatively rigid and biologically compatible material, having pores for impregnation with drugs or medicaments for infection treatment prior to or during insertion thereof in the stabilization site. An assembly for treatment of human limb infections including such device.

Abstract: A disposable articulated spacing device for use as a temporary joint prosthesis includes a first member secured during an implantation procedure to a first articulation end and a separate and independent second member secured separately during the implantation procedure to the other articulation end, both members being pre-formed and made entirely of biological compatible and porous material suitable to be added with pharmaceutical and therapeutical products. The pre-formed members are reciprocally coupled in an articulated manner to maintain a suitable joint space and at least a partial articulation for the time necessary to perform the further implantation of a joint prosthesis.

Abstract: An acrylic radiopaque bone cement for orthopedic use comprises a solid phase composed of a mixture of at least one poly(methyl acrylate)-based polymer, one free-radical polymerization initiator and one or more substances opaque to X-rays, and a liquid phase substantially composed of a mixture of at least one monomer, one accelerator and one stabilizer. The radiopaque substances comprise metallic tungsten and tantalum particles, compounds or mixtures thereof, covered with a polymer coating compatible with said bone cement. The coating layer of the particles of radiopaque substances is an acrylic polymer based on poly(methyl methacrylate). The amount of radiopacifying element is between 1% and 20% by weight, relative to the solid phase, preferably between 2% and 5% by weight, relative to the solid phase. The solid phase may additionally comprise one or more pharmacologically active substances.

Abstract: A disposable articulated spacing device for the treatment of joints of the human body, particularly for temporarily replacing an explanted joint prosthesis, comprises at least one first member able to be secured to a first articulation end and at least one second member able to be secured to the other articulation end, both said members being pre-formed and made entirely of biological compatible and porous material suitable to be added with pharmaceutical and therapeutical products. The pre-formed members are reciprocally coupled in an articulated manner to maintain a suitable joint space and at least a partial articulation for the time necessary to perform the further implantation of a joint prosthesis. The biologically compatible and porous material is chosen among metals, metallic alloys, organo-metals, ceramics, glasses, plastics materials, bone cements and combinations thereof.

Abstract: A disposable articulated spacing device for the treatment of joints of the human body, particularly for temporarily replacing an explanted joint prosthesis, comprises at least one first member able to be secured to a first articulation end and at least one second member able to be secured to the other articulation end, both said members being pre-formed and made entirely of biological compatible and porous material suitable to be added with pharmaceutical and therapeutical products. The pre-formed members are reciprocally coupled in an articulated manner to maintain a suitable joint space and at least a partial articulation for the time necessary to perform the further implantation of a joint prosthesis. The biologically compatible and porous material is chosen among metals, metallic alloys, organo-metals, ceramics, glasses, plastics materials, bone cements and combinations thereof.

Abstract: A metacarpal-phalangeal and/or interphalangeal (1) prosthesis, particularly for joints in the hand or foot, comprising a pair of pins (2, 3) which can be implanted in bone adjacent to a joint to be restored and connected by a flexible joint (4) encapsulated in a protective enclosure formed from the same biocompatible material as the pins. The biocompatible material may be a mixture of plastic resins having high compatibility. The enclosure comprises a pair of half shells (5, 6)integral with the corresponding pins which extend axially on opposite side of a longitudinal plane of symmetry (S) which perpendicularly intersects the axis of rotation (a) of the joint. In a first embodiment, axis (a) is defined by a cylindrical pin (13) inserted in the axial cavity in the half shells and free to rotate with respect to at least one axis with limited flexibility in a plane perpendicular to the axis of rotation (a).