Abstract: A patient stimulation device is provided comprising a plurality of stimulators for selectively applying a stimulus to a patient's body. Each of the plurality of stimulators is locatable in a different position upon a patient's body. A patient input interface is provided for receiving data representative of a perceived stimulus from the patient, and an output is provided for communicating to a patient data representative of an applied stimulus. The device comprises a controller having a training mode, the training mode comprising the controller actuating at least one of the plurality of stimulators to apply a stimulus to the patient's body, subsequently receiving data representative of a perceived stimulus from the patient input interface, and subsequently providing the output with data representative of the applied stimulus for communication to the patient, such that the data representative of the applied stimulus identifies, or allows the identification of, the applied stimulus.

Abstract: The invention relates to neurodegenerative disorders, and in particular to novel oligonucleotides for treating such conditions, for example Alzheimer's disease. The invention provides novel antisense oligonucleotides, and compositions comprising such oligos, and therapies and methods for treating neurodegenerative disorders. The invention includes genome editing techniques for achieving similar results as using the novel antisense oligonucleotides.

Abstract: A patient stimulation device is provided comprising a plurality of stimulators for selectively applying a stimulus to a patient's body. Each of the plurality of stimulators is locatable in a different position upon a patient's body. A patient input interface is provided for receiving data representative of a perceived stimulus from the patient, and an output is provided for communicating to a patient data representative of an applied stimulus. The device comprises a controller having a training mode, the training mode comprising the controller actuating at least one of the plurality of stimulators to apply a stimulus to the patient's body, subsequently receiving data representative of a perceived stimulus from the patient input interface, and subsequently providing the output with data representative of the applied stimulus for communication to the patient, such that the data representative of the applied stimulus identifies, or allows the identification of, the applied stimulus.

Abstract: A method of measuring expended energy of a moving body, including providing a first sensor for measuring data of a first part of the moving body; providing a second sensor for measuring data of a second part of the moving body, wherein the second part is moveable relative to the first part and connected to the first part by a first resistive deformable element that is external to the moving body; using the first sensor to make a first measurement and subsequently calculating a global expended energy of the first part relative to a reference frame; using the second sensor to make a second measurement and subsequently calculating a relative expended energy of the second part relative to the first part; and calculating the total expended energy of the moving body by summing the global expended energy with the relative expended energy.

Abstract: A computer implemented method and system for generating an alternative audible, visual and/or textual data based upon an original audible, visual and/or textual data comprising the step of inputting to a processor original audible, visual and/or textual data having an original plot, extracting a plurality of basic segments from the original audible, visual and/or textual data, defining a vocabulary of intermediate-level semantic concepts based on the plurality of basic segments and/or the original plot, inputting to the processor at least an alternative plot based upon the original plot, modifying the alternative plot in terms of the vocabulary of intermediate-level semantic concepts for generating a modified alternative plot, and modifying the plurality of basic segments of the original audible, visual and/or textual data in terms of said vocabulary of intermediate-level semantic concepts for generating a modified plurality of basic segments.

Abstract: The invention relates to an apparatus and method for the detection of the spectral absorption properties of a fluid in a microenvironment, the apparatus comprising a radiation source, a microfluidic device and detection means, wherein the apparatus additionally comprises means for increasing the path length of the radiation through the fluid. Preferably, the means for increasing the path length of the radiation through the fluid comprises two highly reflective mirrors which cause the base path length through the fluid to be increased by many orders of magnitude, and the method comprises Cavity Enhanced Absorption Spectroscopy. The method is especially useful for the handling of small volumes of fluids for chemical and biological processing.