Abstract: The oxygen supply device supplying a user with an oxygen gas for inhalation comprises: a first sensor unit acquiring information on percutaneous arterial oxygen saturation (SpO2) of the user, a second sensor unit acquiring information on respiratory frequency per minute (BPM), and a control unit. Under the condition where the SpO2 level acquired by the first sensor unit is equal to or larger than the predetermined first threshold and the BPM value acquired by second sensor unit is equal to or larger than the predetermined second threshold, the control unit regards the condition as a possible sign of CO2 narcosis that exhibits an increase in PaCO2 level, and thus judges the condition as an abnormal sign. Then the control unit executes controls such as stopping supply of the oxygen gas to the user, and the like.

Abstract: Provided are an oxygen concentrator, a control method, and a control program capable of preventing a drop in pilot pressure supplied to a pilot type solenoid valve used in at least either of the supply flow path opening/closing unit or the exhaust flow path opening/closing unit. An oxygen concentrator capable of preventing a pressure drop in both cylinders in the pressure equalization step and, as a result, preventing a drop in pilot pressure supplied to a pilot type solenoid valve used in at least either of the supply flow path opening/closing unit or the exhaust flow path opening/closing unit, as well as a pressure drop in the adsorption cylinder, by starting pressurization in advance in the already depressurized adsorption cylinder before the pressure equalization step.

Abstract: Provided are an oxygen concentrator, a control method, and a control program capable of preventing an internal pressure drop of the concentrated oxygen gas tank in order to extract concentrated oxygen gas at a predetermined flow rate. An oxygen concentrator capable of preventing a pressure drop in both cylinders in the pressure equalization step and, as a result, preventing a drop in the internal pressure of a concentrated oxygen gas tank, by starting pressurization in advance in the already depressurized adsorption cylinder before the pressure equalization step.

Abstract: Provided are an oxygen concentrator, a control method, and a control program capable of preventing a drop in pilot pressure supplied to a pilot type solenoid valve used in at least either of the supply flow path opening/closing unit or the exhaust flow path opening/closing unit. An oxygen concentrator capable of preventing a pressure drop in both cylinders in the pressure equalization step and, as a result, preventing a drop in pilot pressure supplied to a pilot type solenoid valve used in at least either of the supply flow path opening/closing unit or the exhaust flow path opening/closing unit, as well as a pressure drop in the adsorption cylinder, by starting pressurization in advance in the already depressurized adsorption cylinder before the pressure equalization step.

Abstract: A nitric oxide administration device 1 includes a first flow path 101 including a first intake port 101a and an oxygen supply port 101b, an oxygen generation unit 100 which is arranged in the first flow path 101 and which generates concentrated oxygen from air introduced via the first intake port 101a, the generated concentrated oxygen being supplied via the oxygen supply port 101b, a second flow path 201 which is branched from the first flow path 101 and which includes an NO supply port 201b, and an NO generation unit 200 which is arranged in the second flow path 201 and which generates NO from gas distributed from the first flow path 101, the generated NO being supplied via the NO supply port 201b.

Abstract: An oxygen therapy system receives data for an elapsed time such as a flow rate of oxygen gas, and a blood oxygen level or a carbon dioxide partial pressure in arterial blood (PaCO2) level of a user, from an oxygen supply device, calculates a proportion of a duration for each oxygen gas flow rate during which the blood oxygen level or PaCO2 is in a prescribed range from the acquired data in which the oxygen gas flow rate fluctuates with the blood oxygen level or carbon dioxide partial pressure in arterial blood (PaCO2), and displays the calculated data as a histogram or pie graph on a terminal which a healthcare worker such as a physician operates.

Abstract: Provided is a transcranial magnetic stimulator capable of providing a magnetic stimulation with a required intensity inside a brain even when a current value and a voltage value applied to magnetic stimulation coils in a plurality of resonant circuits are reduced. The transcranial magnetic stimulator includes a plurality of resonant circuits for applying respective pulse currents to a plurality of magnetic stimulation coils to generate variable magnetic fields, and a power source that supplies an electric power to the plurality of resonant circuits. The plurality of resonant circuits are connected in parallel to the power source, and therefore, the plurality of magnetic stimulation coils are also connected in parallel to the power source. The plurality of magnetic stimulation coils are formed in approximately a same shape, and adjacently disposed such that directions of magnetic fluxes generated by the applied pulse currents are matched.

Abstract: An object of the present invention is to provide a phototherapy device with which a light irradiation region can be accurately positioned on a treatment site. The phototherapy device according to an embodiment of the present disclosure includes a barrel, a light source which is installed inside the barrel and which emits light, a plurality of imaging units for imaging a marking arranged on a body, a deviation amount calculation unit for calculating a deviation amount between a plurality of images of the marking included in a plurality of images captured by the plurality of imaging units, an image combining unit for combining the plurality of images of the marking based on the calculated deviation amount, a target position determination unit for determining a position of a target in the combined image corresponding to an irradiation region of light from the light source, and a display unit for overlaying and displaying an image of a target on the combined image of the marking.

Abstract: An object of the present invention is to provide a new indication for phototherapy or prevention, and to provide a new treatment or prevention device for irritable bowel syndrome. The present invention is a device for treating or preventing irritable bowel syndrome, specifically a light beam irradiation device for treating or preventing irritable bowel syndrome by performing percutaneous irradiation toward the sacral foramina on one side or both sides and the vicinity thereof.

Abstract: The invention provides methods for using and compositions of humanized antibodies that bind tau protein that is phosphorylated at the serine at position 413.

Abstract: Provided is an exacerbation prediction device equipped with a respiration sensing means of continuously sensing respiration data of a patient, a calculation means of calculating stable respiration data that are respiration data during a condition in which a respiratory rate is lowered and stable for a certain period of time from the sensed continuous respiration data of the patient, and a prediction means of predicting occurrence of an acute exacerbation in the patient in accordance with the stable respiration data calculated during a certain period of time.

Abstract: The present invention provides an anti-IGF-I receptor antibody that binds specifically to an IGF-I receptor of a vertebrate and has the proliferation-inducing activity of a vertebrate-derived cell, or a fragment thereof, or derivatives of these.

Abstract: The purpose of the present invention is to provide an antibody that can be expected to have a therapeutic effect in autoimmune diseases and anticancer treatment by inhibiting S1P transport by SPNS2 to thereby inhibit lymphocyte migration. The present invention is an SPNS2 neutralizing antibody or a fragment thereof, or a derivative thereof, that specifically binds to vertebrate SPNS2 and has lymphocyte migration inhibitory activity through SW transport inhibition.

Abstract: A respiratory information acquisition device used for a PSA type oxygen concentration device that switches and uses multiple adsorption cylinders includes a respiratory information acquisition means of measuring a first pressure of a periodic pressure fluctuation in an oxygen supply path when oxygen is supplied to a patient from the PSA type oxygen concentration device and a second pressure of a periodic pressure fluctuation in the oxygen supply path when oxygen is not supplied to the patient from the PSA type oxygen concentration device, a phase confirmation means of matching phases of the first pressure and the second pressure, and a subtraction processing means of calculating a difference between the first pressure and the second pressure in the condition where the phases are matched.

Abstract: A compound indicated by formula (I) or a pharmacologically acceptable salt thereof is provided as a compound that can be a therapeutic or prophylactic drug for TRPC6-related diseases, such as nephrotic syndrome, membranous nephropathy, acute renal failure, septicemia, chronic renal failure, diabetic nephropathy, pulmonary hypertension, acute lung injury, heart failure, malignant tumor, and muscular dystrophy. (In the formula, Ar1, Ar2, X1-X3, R1, R3, R7, R8, L1, and L2 are as defined in the specifications.

Abstract: Provided is an oxygen concentration device that can facilitate easy and secure replacement work, such as attaching and detaching the adsorption cylinder while reducing the force applied from the oxygen concentration device body to the adsorption cylinder cartridge in the direction of detaching and thus ensuring the connection with the oxygen concentration device, wherein the axis line of the gas flow direction of the adsorption cylinder intersects with either connection axis in the end part for supplying pressurized air to the adsorption cylinder or the end part for extracting oxygen from the adsorption cylinder.

Abstract: The present invention provides an anti-IGF-I receptor antibody that binds specifically to an IGF-I receptor of a vertebrate and has the proliferation-inducing activity of a vertebrate-derived cell, or a fragment thereof, or derivatives of these.

Abstract: An object of the present invention is to provide a chair-type phototherapy device that enables a patient to perform light irradiation accurately targeted at a treatment site in a seated position on a chair and consequently achieves effective phototherapy even when the treatment site is in the back region that the patient is unable to see, for example, as in light irradiation for dysuria patients and patients with pain, and the patient performs light irradiation by himself/herself at home. The present invention provides a chair-type phototherapy device having a seat on which a patient is seated. The chair-type phototherapy device includes a radiation module configured to emit radiation light toward a living body, a drive module positioned behind the patient for moving the radiation module, and a fixing module fixing the drive module to the seat.

Abstract: [Summary] [Purpose] The invention provides a novel therapeutic agent or prophylactic agent for cognitive disorders. [Solution Means] The invention provides an antibody that participates in antigen-antibody reaction specifically with tau protein that has been phosphorylated in the vicinity of Ser413 of SEQ ID NO: 1, and a therapeutic agent or prophylactic agent for cognitive disorders comprising as an active ingredient a peptide that has been phosphorylated in the vicinity of Ser413.

Abstract: The device of the invention is equipped with a pressure sensor and a control unit, and the control unit judges a point at which a pressure gradient calculated from a signal of the pressure sensor becomes larger in the absolute value than a pressure gradient threshold as an inspiration sensing point and starts respiratory gas supply. In addition, the device judges from a frequency of the inspiration sensing point during predetermined time whether a pressure gradient threshold used as a criterion for the inspiration sensing point corresponds to an activity state of the user, and when the pressure gradient threshold does not correspond to the activity state, switches the pressure gradient threshold to another threshold and thus fits the pressure gradient threshold to the activity state.